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Abstract:

Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi.

Registro:

Documento: Artículo
Título:Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
Autor:Ravaschino, E.L.; Docampo, R.; Rodriguez, J.B.
Filiación:Departamento de Quimica Organica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA, Buenos Aires, Argentina
Department of Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, IL 61802, United States
Palabras clave:American trypanosomiasis; Glutathionylspermidine synthase; Trypanosoma cruzi; Trypanothione; gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide; gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide; glutathione derivative; glutathionylspermidine synthase; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide; n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide; spermidine synthase; tripeptide derivative; unclassified drug; article; Chagas disease; drug screening; drug structure; nonhuman; peptide synthesis; Trypanosoma cruzi
Año:2003
Volumen:2003
Número:10
Página de inicio:298
Página de fin:313
Título revista:Arkivoc
Título revista abreviado:Arkivoc
ISSN:14246376
CAS:spermidine synthase, 37277-82-0, 67016-02-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino

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Citas:

---------- APA ----------
Ravaschino, E.L., Docampo, R. & Rodriguez, J.B. (2003) . Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi. Arkivoc, 2003(10), 298-313.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino [ ]
---------- CHICAGO ----------
Ravaschino, E.L., Docampo, R., Rodriguez, J.B. "Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi" . Arkivoc 2003, no. 10 (2003) : 298-313.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino [ ]
---------- MLA ----------
Ravaschino, E.L., Docampo, R., Rodriguez, J.B. "Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi" . Arkivoc, vol. 2003, no. 10, 2003, pp. 298-313.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino [ ]
---------- VANCOUVER ----------
Ravaschino, E.L., Docampo, R., Rodriguez, J.B. Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi. Arkivoc. 2003;2003(10):298-313.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino [ ]