Artículo
Duschatzky, C.B.; Possetto, M.L.; Talarico, L.B.; García, C.C.; Michis, F.; Almeida, N.V.; De Lampasona, M.P.; Schuff, C.; Damonte, E.B. "Evaluation of chemical and antiviral properties of essential oils from South American plants" (2005) Antiviral Chemistry and Chemotherapy. 16(4):247-251
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Abstract:
The essential oils of seven aromatic plants from Córdoba, San Luis and San Juan Provinces (Argentina) were isolated by steam distillation and analysed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV) by a virucidal test. The oils showed a variable virucidal action according to the virus. The better relationship between cytotoxicity and anti-virus action was observed with the essential oils of Heterothalamus alienus and Buddleja cordobensis against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal activity ratio) of 3.3 and 4.0, respectively. The inhibitory action was exerted by a direct interaction of virions with the oils. Virions inactivated with B. cordobensis and H. alienus essential oil were not affected in their ability to bind to the host cell. The therapeutic indices shown by these essential oils in toto were very modest, but given the complexity of their chemical composition the future identification of the precise active principle may allow the elimination of cytotoxic components and increase the selectivity of the effective compound. ©2005 International Medical Press.
Registro:
| Documento: | Artículo |
| Título: | Evaluation of chemical and antiviral properties of essential oils from South American plants |
| Autor: | Duschatzky, C.B.; Possetto, M.L.; Talarico, L.B.; García, C.C.; Michis, F.; Almeida, N.V.; De Lampasona, M.P.; Schuff, C.; Damonte, E.B. |
| Filiación: | FICES, Universidad Nacional de San Luis, San Luis, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina |
| Palabras clave: | Dengue virus; Essential oils; Herpes simplex virus; Junin virus; South American plants; Virus inactivation; essential oil; plant extract; antiviral activity; Argentina; article; Asteraceae; Buddleja; Buddleja cordobensis; controlled study; cytotoxicity; Dengue virus; drug isolation; drug screening; gas chromatography; Herpes simplex virus 1; Heterothalamus alienus; in vitro study; Junin virus; mass spectrometry; medicinal plant; nonhuman; priority journal; South America; virion; virus cell interaction; virus inactivation; virus inhibition; virus strain |
| Año: | 2005 |
| Volumen: | 16 |
| Número: | 4 |
| Página de inicio: | 247 |
| Página de fin: | 251 |
| DOI: | http://dx.doi.org/10.1177/095632020501600404 |
| Título revista: | Antiviral Chemistry and Chemotherapy |
| Título revista abreviado: | Antiviral Chem. Chemother. |
| ISSN: | 09563202 |
| CODEN: | ACCHE |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v16_n4_p247_Duschatzky |
Referencias:
- Allahverdiyev, A., Duran, N., Ozguven, M., Koltas, S., Antiviral activity of the volatile oils of Melissa officinalis L against herpes simplex virus type-2 (2004) Phytomedicine, 11, pp. 657-661
- Armaka, M., Papanikolau, E., Sivropoulou, A., Arsenakis, M., Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1 (1999) Antiviral Research, 43, pp. 79-92
- Benencia, F., Courreges, M.C., Antiviral activity of sandal-wood oil against herpes simplex viruses-1 and -2 (1999) Phytomedicine, 6, pp. 119-123
- Cowan, M.M., Plant products as antimicrobial agents (1999) Clinical Microbiology Reviews, 12, pp. 564-582
- Damonte, E.B., Coto, C.E., Treatment of arenavirus infections: From basic studies to the challenge of antiviral therapy (2002) Advances in Virus Research, 58, pp. 125-155
- Damonte, E.B., Mersich, S.E., Candurra, N.A., Intracellular processing and transport of Junin virus glycoproteins influences virion infectivity (1994) Virus Research, 34, pp. 317-326
- De Logu, A., Loy, G., Pellerano, M.L., Bonsignore, L., Schivo, M.L., Inactivation of HSV-1 and HSV-2 and prevention of cell-to-cell spread by Santolina insularis essential oil (2000) Antiviral Research, 48, pp. 177-185
- Duschatzky, C., Almeida, N., Colombres, S., Lampasona, M., Essential oil of Gaillardia megapotamica (Spreng.) Backer, var. Radiata (Gris.) Backer from San Luis, Argentina (2003) Journal of Essential Oil Research, 15, pp. 112-113
- Farag, R.S., Shalaby, A.S., El-Baroty, G.A., Ibrahim, N.A., Ali, M.A., Hassan, E.M., Chemical and biological evaluation of the essential oils of different Melaleuca species (2004) Phytotherapy Research, 18, pp. 30-35
- García, C.C., Candurra, N.A., Damonte, E.B., Antiviral and virucidal activities against arenaviruses of zinc-finger active compounds (2000) Antiviral Chemistry & Chemotherapy, 11, pp. 231-238
- García, C.C., Talarico, L., Almeida, N., Colombres, S., Duschatzky, C., Damonte, E.B., Virucidal activity of essential oils from aromatic plants of San Luis, Argentina (2003) Phytotherapy Research, 17, pp. 1073-1075
- Gubler, D.J., Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century (2002) Trends in Microbiology, 10, pp. 100-103
- Hayashi, K., Kamiya, M., Hayashi, T., Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus and HIV (1995) Planta Medica, 61, pp. 237-241
- McLafferty, F.W., Stauffer, D.B., (1994) Wiley Registry of Mass Spectral Data, 6th Ed., , Mass Spectrometry Library Search System, Bench-Top PBM, version 3.10d. Palisade: Newfield
- Minami, M., Kita, M., Nakaya, T., Yamamoto, T., Kuriyama, H., Imanishi, J., The inhibitory effect of essential oils on herpes simplex virus type-1 replication in vitro (2003) Microbiology & Immunology, 47, pp. 681-684
- Primo, V., Rovera, M., Zanon, S., Oliva, M., Demo, M., Daghero, J., Sabini, L., Determination of the antibacterial and antiviral activity of the essential oil from Minthostachys verticillata (Griseb.) Epling (2001) Revista Argentina de Microbiología, 33, pp. 113-117
- Schnitzler, P., Schon, K., Reichling, J., Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture (2001) Pharmazie, 56, pp. 343-347
- Schuhmacher, A., Reichling, J., Schnitzler, P., Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus typel and type 2 in vitro (2003) Phytomedicine, 10, pp. 504-510
- Sinico, C., De Logu, A., Lai, F., Valenti, D., Manconi, M., Loy, G., Bonsignore, L., Fadda, A.M., Liposomal incorporation of Artemisia arborescens L essential oil and in vitro antiviral activity (2005) European Journal of Pharmaceutics & Biopharmaceutics, 59, pp. 161-168
- Sivropoulou, A., Nikolau, C., Papanikolau, E., Kokkini, S., Lanaras, T., Arsenakis, M., Antimicrobial, cytotoxic, and antiviral activities of Salviafruticosa essential oil (1997) Journal of Agricultural & Food Chemistry, 45, pp. 3197-3201
- Vijayan, P., Raghu, C., Ashok, G., Dhanaraj, S.A., Suresh, B., Antiviral activity of medicinal plant of Nilgiris (2004) Indian Journal of Medicinal Research, 120, pp. 24-29
- Vlietinck, A.J., De Bruyne, T., Apers, S., Pieters, L.A., Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection (1998) Planta Medica, 64, pp. 97-109
Citas:
---------- APA ----------
Duschatzky, C.B., Possetto, M.L., Talarico, L.B., García, C.C., Michis, F., Almeida, N.V., De Lampasona, M.P.,..., Damonte, E.B. (2005) . Evaluation of chemical and antiviral properties of essential oils from South American plants. Antiviral Chemistry and Chemotherapy, 16(4), 247-251.http://dx.doi.org/10.1177/095632020501600404
---------- CHICAGO ----------
Duschatzky, C.B., Possetto, M.L., Talarico, L.B., García, C.C., Michis, F., Almeida, N.V., et al. "Evaluation of chemical and antiviral properties of essential oils from South American plants" . Antiviral Chemistry and Chemotherapy 16, no. 4 (2005) : 247-251.http://dx.doi.org/10.1177/095632020501600404
---------- MLA ----------
Duschatzky, C.B., Possetto, M.L., Talarico, L.B., García, C.C., Michis, F., Almeida, N.V., et al. "Evaluation of chemical and antiviral properties of essential oils from South American plants" . Antiviral Chemistry and Chemotherapy, vol. 16, no. 4, 2005, pp. 247-251.http://dx.doi.org/10.1177/095632020501600404
---------- VANCOUVER ----------
Duschatzky, C.B., Possetto, M.L., Talarico, L.B., García, C.C., Michis, F., Almeida, N.V., et al. Evaluation of chemical and antiviral properties of essential oils from South American plants. Antiviral Chem. Chemother. 2005;16(4):247-251.http://dx.doi.org/10.1177/095632020501600404
