Abstract:
An in vivo antitumor screening of extracts of Gomphrena martiana indicated positive activity in the petroleum ether extract, and its further bioactivity-directed fractionation resulted in a lipophilic flavonoid fraction. Upon inoculation of various doses of 5,6,7-trisubstituted flavones on two murine tumor lines, Sarcoma 180 and Ehrlich's carcinoma, a decrease of tumor growth was observed. An in vitro KB cultured cell screen indicated cytotoxicity. © 1994.
Registro:
Documento: |
Artículo
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Título: | Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana |
Autor: | Pomilio, A.B.; Rutty Solá, G.A.; Mayer, A.M.S.; Rumi, L.S. |
Filiación: | PROPLAME-CON1CET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina lnstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina Academia Nacional de Medicina, Buenos Aires, Argentina
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Palabras clave: | 5,6,7-Trisubstituted flavonoids; Antitumor activity; Cytotoxicity; Gomphrena martiana; flavonoid; gomphrena martiana extract; plant extract; unclassified drug; animal cell; animal experiment; animal model; antineoplastic activity; article; cancer cell culture; cell culture; controlled study; cytotoxicity; drug activity; drug screening; Ehrlich ascites tumor; female; fractionation; human; human cell; intraperitoneal drug administration; lipophilicity; male; mouse; nonhuman; sarcoma 180; tumor growth |
Año: | 1994
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Volumen: | 44
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Número: | 1
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Página de inicio: | 25
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Página de fin: | 33
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DOI: |
http://dx.doi.org/10.1016/0378-8741(94)90095-7 |
Título revista: | Journal of Ethnopharmacology
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Título revista abreviado: | J. Ethnopharmacol.
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ISSN: | 03788741
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CODEN: | JOETD
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v44_n1_p25_Pomilio |
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Citas:
---------- APA ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S. & Rumi, L.S.
(1994)
. Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana. Journal of Ethnopharmacology, 44(1), 25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7---------- CHICAGO ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S., Rumi, L.S.
"Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana"
. Journal of Ethnopharmacology 44, no. 1
(1994) : 25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7---------- MLA ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S., Rumi, L.S.
"Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana"
. Journal of Ethnopharmacology, vol. 44, no. 1, 1994, pp. 25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7---------- VANCOUVER ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S., Rumi, L.S. Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana. J. Ethnopharmacol. 1994;44(1):25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7