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Abstract:

An in vivo antitumor screening of extracts of Gomphrena martiana indicated positive activity in the petroleum ether extract, and its further bioactivity-directed fractionation resulted in a lipophilic flavonoid fraction. Upon inoculation of various doses of 5,6,7-trisubstituted flavones on two murine tumor lines, Sarcoma 180 and Ehrlich's carcinoma, a decrease of tumor growth was observed. An in vitro KB cultured cell screen indicated cytotoxicity. © 1994.

Registro:

Documento: Artículo
Título:Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana
Autor:Pomilio, A.B.; Rutty Solá, G.A.; Mayer, A.M.S.; Rumi, L.S.
Filiación:PROPLAME-CON1CET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
lnstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
Academia Nacional de Medicina, Buenos Aires, Argentina
Palabras clave:5,6,7-Trisubstituted flavonoids; Antitumor activity; Cytotoxicity; Gomphrena martiana; flavonoid; gomphrena martiana extract; plant extract; unclassified drug; animal cell; animal experiment; animal model; antineoplastic activity; article; cancer cell culture; cell culture; controlled study; cytotoxicity; drug activity; drug screening; Ehrlich ascites tumor; female; fractionation; human; human cell; intraperitoneal drug administration; lipophilicity; male; mouse; nonhuman; sarcoma 180; tumor growth
Año:1994
Volumen:44
Número:1
Página de inicio:25
Página de fin:33
DOI: http://dx.doi.org/10.1016/0378-8741(94)90095-7
Título revista:Journal of Ethnopharmacology
Título revista abreviado:J. Ethnopharmacol.
ISSN:03788741
CODEN:JOETD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v44_n1_p25_Pomilio

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Citas:

---------- APA ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S. & Rumi, L.S. (1994) . Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana. Journal of Ethnopharmacology, 44(1), 25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7
---------- CHICAGO ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S., Rumi, L.S. "Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana" . Journal of Ethnopharmacology 44, no. 1 (1994) : 25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7
---------- MLA ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S., Rumi, L.S. "Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana" . Journal of Ethnopharmacology, vol. 44, no. 1, 1994, pp. 25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7
---------- VANCOUVER ----------
Pomilio, A.B., Rutty Solá, G.A., Mayer, A.M.S., Rumi, L.S. Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana. J. Ethnopharmacol. 1994;44(1):25-33.
http://dx.doi.org/10.1016/0378-8741(94)90095-7