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de Almeida, M.T.R.; Tonini, M.L.; Guimarães, T.R.; Bianco, E.M.; Moritz, M.I.G.; Oliveira, S.Q.; Cabrera, G.M.; Palermo, J.A.; Reginatto, F.H.; Steindel, M.; Schenkel, E.P. "Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil" (2012) Latin American Journal of Pharmacy. 31(10):1489-1495
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Abstract:

In the present work, fractions of the ethanolic crude extract of Carijoa riisei (Octocorallia) collected at South Brazil (Santa Catarina island) were tested against different bacterial, fungal and protozoal pathogens. The n-hexane fraction (HF) showed a moderate activity against S. aureus in the disk diffusion method, and inhibited 43.4 and 35.9% the growing of T. cruzi epimastigotes and L. braziliensis promastigotes, respectively. The steroid pregna-1,4,20-trien-3-one was isolated from HF and presented in vitro antiprotozoal activity against the extracellular forms of the parasites at 50 μM, showing 50.4% growth inhibition of L. braziliensis and 42.4% growth inhibition of T. cruzi.

Registro:

Documento: Artículo
Título:Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil
Autor:de Almeida, M.T.R.; Tonini, M.L.; Guimarães, T.R.; Bianco, E.M.; Moritz, M.I.G.; Oliveira, S.Q.; Cabrera, G.M.; Palermo, J.A.; Reginatto, F.H.; Steindel, M.; Schenkel, E.P.
Filiación:Universidade Federal de Santa Catarina, Campus Universitário Trindade, CEP 88.040-900, Florianópolis, SC, Brazil
Laboratório de Protozoologia, Universidade Federal de Santa Catarina, Campus Universitário Trindade, CEP 88.040-900, Florianópolis, SC, Brazil
Departamento de Botânica, Universidade Federal de Santa Catarina, Campus Universitário Trindade, CEP 88.040-900, Florianópolis, SC, Brazil
UMYMFOR - Departamento de Química Orgánica, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2(1428), Buenos Aires, Argentina
Palabras clave:Antiprotozoal; Carijoa riisei; Leishmania braziliensis; Octocoral; Pregnane sterol; Trypanosoma cruzi; alcohol; amphotericin B; ampicillin; antibiotic agent; antifungal agent; antiprotozoal agent; benznidazole; butanol; Carijoa riisei extract; ceftazidime; chloramphenicol; cloxacillin; fluconazole; hexane; imipenem; levofloxacin; oxacillin; plant extract; pregna 1,4,20 trien 3 one; pregnane derivative; unclassified drug; water; animal cell; antibacterial activity; antifungal activity; antimicrobial activity; antiprotozoal activity; article; bacterial growth; Brazil; Carijoa riisei; controlled study; coral reef; cytotoxicity test; disk diffusion; drug screening; drug structure; epimastigote; fungus growth; growth inhibition; in vitro study; Leishmania braziliensis; mouse; nonhuman; promastigote; Staphylococcus aureus; Trypanosoma cruzi
Año:2012
Volumen:31
Número:10
Página de inicio:1489
Página de fin:1495
Título revista:Latin American Journal of Pharmacy
Título revista abreviado:Lat. Am. J. Pharm.
ISSN:03262383
CAS:alcohol, 64-17-5; amphotericin B, 1397-89-3, 30652-87-0; ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0; benznidazole, 22994-85-0; butanol, 35296-72-1, 71-36-3; ceftazidime, 72558-82-8; chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; cloxacillin, 61-72-3, 642-78-4; fluconazole, 86386-73-4; hexane, 110-54-3; imipenem, 64221-86-9; levofloxacin, 100986-85-4, 138199-71-0; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; water, 7732-18-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03262383_v31_n10_p1489_deAlmeida

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Citas:

---------- APA ----------
de Almeida, M.T.R., Tonini, M.L., Guimarães, T.R., Bianco, E.M., Moritz, M.I.G., Oliveira, S.Q., Cabrera, G.M.,..., Schenkel, E.P. (2012) . Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil. Latin American Journal of Pharmacy, 31(10), 1489-1495.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03262383_v31_n10_p1489_deAlmeida [ ]
---------- CHICAGO ----------
de Almeida, M.T.R., Tonini, M.L., Guimarães, T.R., Bianco, E.M., Moritz, M.I.G., Oliveira, S.Q., et al. "Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil" . Latin American Journal of Pharmacy 31, no. 10 (2012) : 1489-1495.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03262383_v31_n10_p1489_deAlmeida [ ]
---------- MLA ----------
de Almeida, M.T.R., Tonini, M.L., Guimarães, T.R., Bianco, E.M., Moritz, M.I.G., Oliveira, S.Q., et al. "Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil" . Latin American Journal of Pharmacy, vol. 31, no. 10, 2012, pp. 1489-1495.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03262383_v31_n10_p1489_deAlmeida [ ]
---------- VANCOUVER ----------
de Almeida, M.T.R., Tonini, M.L., Guimarães, T.R., Bianco, E.M., Moritz, M.I.G., Oliveira, S.Q., et al. Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil. Lat. Am. J. Pharm. 2012;31(10):1489-1495.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03262383_v31_n10_p1489_deAlmeida [ ]