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Talarico, L.B.; Zibetti, R.G.M.; Faria, P.C.S.; Scolaro, L.A.; Duarte, M.E.R.; Noseda, M.D.; Pujol, C.A.; Damonte, E.B. "Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata" (2004) International Journal of Biological Macromolecules. 34(1-2):63-71
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Abstract:

This study presents the chemical composition and antiviral activity against herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) of sulfated galactan crude extracts and main fractions obtained from two red seaweeds collected in Brazil, Gymnogongrus griffithsiae and Cryptonemia crenulata. Most of the eighteen tested products, including homogeneous kappa/iota/nu carrageenan and DL-galactan hybrid, exhibited antiherpetic activity with inhibitory concentration 50% (IC50) values in the range 0.5-5.6 μg/ml, as determined in a virus plaque reduction assay in Vero cells. The galactans lacked cytotoxic effects and showed a broad spectrum of antiviral activity against HSV-1 and HSV-2. No direct virus inactivation was observed after virion treatment with the galactans. The mode of action of these compounds could be mainly ascribed to an inhibitory effect on virus adsorption. Most importantly, a significant protection against a murine vaginal infection with HSV-2 was afforded by topical treatment with the sulfated galactans. © 2004 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata
Autor:Talarico, L.B.; Zibetti, R.G.M.; Faria, P.C.S.; Scolaro, L.A.; Duarte, M.E.R.; Noseda, M.D.; Pujol, C.A.; Damonte, E.B.
Filiación:Laboratorio de Virología, Depto. de Quím. Biol., Pabellón 2, 1428 Buenos Aires, Argentina
Depto. de Bioquim. e Biol. Molec., Univ. Federal Do Paraná, P.O. Box 19046, Paraná, Brazil
Palabras clave:Antiviral activity; D,L-Galactan hybrid; Herpes simplex virus; Kappa/iota/nu carrageenan; Red seaweed; Sulfated polysaccharide; carrageenan; galactan; animal cell; animal experiment; animal model; antiviral activity; article; Brazil; cell assay; chemical composition; controlled study; cryptonemia crenulata; cytotoxicity; drug activity; drug effect; drug mechanism; drug screening; female; gymnogongrus griffithsiae; Herpes simplex virus 1; Herpes simplex virus 2; hybrid; IC 50; inhibition kinetics; mouse; nonhuman; protection; seaweed; sulfation; vaginitis; Vero cell; virion; virus adsorption; virus inactivation; virus plaque; Animals; Antiviral Agents; Brazil; Cercopithecus aethiops; Drug Evaluation, Preclinical; Female; Galactans; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Seaweed; Simplexvirus; Sulfates; Toxicity Tests; Vaginal Diseases; Vero Cells; algae; Cryptonemia; Cryptonemia crenulata; Gymnogongrus; Gymnogongrus griffithsiae; Human herpesvirus 1; Human herpesvirus 2; Murinae; Simplexvirus
Año:2004
Volumen:34
Número:1-2
Página de inicio:63
Página de fin:71
DOI: http://dx.doi.org/10.1016/j.ijbiomac.2004.03.002
Título revista:International Journal of Biological Macromolecules
Título revista abreviado:Int. J. Biol. Macromol.
ISSN:01418130
CODEN:IJBMD
CAS:carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; galactan, 39300-87-3, 9037-55-2; Antiviral Agents; Galactans; Sulfates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v34_n1-2_p63_Talarico

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Citas:

---------- APA ----------
Talarico, L.B., Zibetti, R.G.M., Faria, P.C.S., Scolaro, L.A., Duarte, M.E.R., Noseda, M.D., Pujol, C.A.,..., Damonte, E.B. (2004) . Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata. International Journal of Biological Macromolecules, 34(1-2), 63-71.
http://dx.doi.org/10.1016/j.ijbiomac.2004.03.002
---------- CHICAGO ----------
Talarico, L.B., Zibetti, R.G.M., Faria, P.C.S., Scolaro, L.A., Duarte, M.E.R., Noseda, M.D., et al. "Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata" . International Journal of Biological Macromolecules 34, no. 1-2 (2004) : 63-71.
http://dx.doi.org/10.1016/j.ijbiomac.2004.03.002
---------- MLA ----------
Talarico, L.B., Zibetti, R.G.M., Faria, P.C.S., Scolaro, L.A., Duarte, M.E.R., Noseda, M.D., et al. "Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata" . International Journal of Biological Macromolecules, vol. 34, no. 1-2, 2004, pp. 63-71.
http://dx.doi.org/10.1016/j.ijbiomac.2004.03.002
---------- VANCOUVER ----------
Talarico, L.B., Zibetti, R.G.M., Faria, P.C.S., Scolaro, L.A., Duarte, M.E.R., Noseda, M.D., et al. Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata. Int. J. Biol. Macromol. 2004;34(1-2):63-71.
http://dx.doi.org/10.1016/j.ijbiomac.2004.03.002