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Abstract:

A new spectrofluorimetric assay for the photodegradation products of the ansiolytic drug alprazolam is described. Alprazolam was found to be highly photolabile and special care should be taken to avoid light exposure during alprazolam storage and handling. The photostability of alprazolam was evaluated at pH 2.0, 3.6 and 5.0. The drug was exposed to UVA-UVB radiations, the photodegradation of alprazolam was followed by high-performance liquid chromatographic (HPLC) and the developed spectrofluorimetric assay allowed determination of the photodegradation products at very low concentrations (≥10-5 M). The photoinstability was found to increase with the pH value decreasing, consequently acidic media should be avoided during the drug-development process. © 2002 Elsevier Science B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Spectrofluorimetric assay for the photodegradation products of alprazolam
Autor:Nudelman, N.S.; Gallardo Cabrera, C.
Filiación:Depto. Quimica Organica, Facultad de Ciencias Exactas y Naturales, 1428 Buenos Aires, Argentina
Palabras clave:Alprazolam photostability; Alprazolam quality control; Alprazolam stability; Benzodiazepine phototoxicity; Spectrofluorimetric assay; alprazolam; article; drug degradation; drug determination; drug screening; drug stability; drug storage; fluorescence; high performance liquid chromatography; light exposure; pH; photodegradation; priority journal; spectrofluorometry; tablet; ultraviolet A radiation; ultraviolet B radiation; validation process; Alprazolam; Drug Stability; Light; Spectrometry, Fluorescence
Año:2002
Volumen:30
Número:3
Página de inicio:887
Página de fin:893
DOI: http://dx.doi.org/10.1016/S0731-7085(02)00351-5
Título revista:Journal of Pharmaceutical and Biomedical Analysis
Título revista abreviado:J. Pharm. Biomed. Anal.
ISSN:07317085
CODEN:JPBAD
CAS:Alprazolam, 28981-97-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07317085_v30_n3_p887_Nudelman

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Citas:

---------- APA ----------
Nudelman, N.S. & Gallardo Cabrera, C. (2002) . Spectrofluorimetric assay for the photodegradation products of alprazolam. Journal of Pharmaceutical and Biomedical Analysis, 30(3), 887-893.
http://dx.doi.org/10.1016/S0731-7085(02)00351-5
---------- CHICAGO ----------
Nudelman, N.S., Gallardo Cabrera, C. "Spectrofluorimetric assay for the photodegradation products of alprazolam" . Journal of Pharmaceutical and Biomedical Analysis 30, no. 3 (2002) : 887-893.
http://dx.doi.org/10.1016/S0731-7085(02)00351-5
---------- MLA ----------
Nudelman, N.S., Gallardo Cabrera, C. "Spectrofluorimetric assay for the photodegradation products of alprazolam" . Journal of Pharmaceutical and Biomedical Analysis, vol. 30, no. 3, 2002, pp. 887-893.
http://dx.doi.org/10.1016/S0731-7085(02)00351-5
---------- VANCOUVER ----------
Nudelman, N.S., Gallardo Cabrera, C. Spectrofluorimetric assay for the photodegradation products of alprazolam. J. Pharm. Biomed. Anal. 2002;30(3):887-893.
http://dx.doi.org/10.1016/S0731-7085(02)00351-5