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Antineoplastic Agents
48
"Selective hemangioma cell dysfunction and apoptosis triggered by in vitro treatment with imiquimod" (2018) Rocco, R.;Alegre, N.;Pozner, R. (...)Gazzaniga, S. Toxicology Letters. 288:82-88
"Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys" (2018) Abiuso, A.M.B.;Varela, M.L.;Haro Durand, L. (...)Mondillo, C. European Journal of Cancer. 91:125-135
"Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry" (2018) Pertino, M.W.; Petrera, E.; Edith Alché, L.; Schmeda-Hirschmann, G. Molecules. 23(6)
"Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides" (2017) Avanzo, R.E.; Padrón, J.M.; D'Accorso, N.B.; Fascio, M.L. Bioorganic and Medicinal Chemistry Letters. 27(16):3674-3677
"Photoactivation of Anticancer Ru Complexes in Deep Tissue: How Deep Can We Go?" (2017) Sun, W.;Thiramanas, R.;Slep, L.D. (...)Wu, S. Chemistry - A European Journal. 23(45):10832-10837
"Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties" (2015) Fascio, M.L.; Errea, M.I.; D'Accorso, N.B. European Journal of Medicinal Chemistry. 90:666-683
"In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B" (2015) Silva, I.T.;Carvalho, A.;Lang, K.L. (...)Ludwig, S. PLoS ONE. 10(2)
"Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549" (2015) Marostica, L.L.;Silva, I.T.;Kratz, J.M. (...)Simões, C.M.O. Chemical Research in Toxicology. 28(10):1949-1960
"Low doses of CPS49 and flavopiridol combination as potential treatment for advanced prostate cancer" (2015) Zalazar, F.;De Luca, P.;Gardner, K. (...)De Siervi, A. Current Pharmaceutical Biotechnology. 16(6):553-563
"Human MageB2 protein expression enhances E2F transcriptional activity, cell proliferation, and resistance to ribotoxic stress" (2015) Peche, L.Y.;Ladelfa, M.F.;Toledo, M.F. (...)Monte, M. Journal of Biological Chemistry. 290(49):29652-29662
"Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties" (2015) Fascio, M.L.; Errea, M.I.; D'Accorso, N.B. European journal of medicinal chemistry. 90:666-683
"Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes" (2015) Rebuzzini, P.;Cebral, E.;Fassina, L. (...)Garagna, S. Scientific Reports. 5
"Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line" (2014) Lang, K.L.;Silva, I.T.;Machado, V.R. (...)De Melo, E.B. Journal of Molecular Graphics and Modelling. 48:70-79
"QSAR on antiproliferative naphthoquinones based on a conformation- independent approach" (2014) Duchowicz, P.R.;Bennardi, D.O.;Bacelo, D.E. (...)Misico, R.I. European Journal of Medicinal Chemistry. 77:176-184
"Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia" (2014) Rocha-Viegas, L.;Villa, R.;Gutierrez, A. (...)Croce, L.D. Molecular and Cellular Biology. 34(19):3765-3775
"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines" (2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (...)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851
"Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases" (2014) Wan, X.;Corn, P.G.;Yang, J. (...)Navone, N.M. Science Translational Medicine. 6(252)
"Differential effect of heterocyclic d-ribofuranoside derivatives on human prostate cancer cell viability and cell cycle progression" (2014) Gueron, G.;Avanzo, R.E.;Schuster, F. (...)D'Accorso, N.B. Biomedicine and Pharmacotherapy. 68(7):847-854
"Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus" (2014) Careaga, V.P.;Bueno, C.;Muniain, C. (...)Maier, M.S. Natural Product Research. 28(4):213-220
"Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas" (2013) Curic, S.;Wu, Y.;Shan, B. (...)Renner, U. Journal of Neuro-Oncology. 113(3):385-396
"Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas" (2012) Shan, B.;Schaaf, C.;Schmidt, A. (...)Renner, U. Journal of Endocrinology. 214(3):389-398
"β-Lapachone analogs with enhanced antiproliferative activity" (2012) Ríos-Luci, C.;Bonifazi, E.L.;León, L.G. (...)Padrón, J.M. European Journal of Medicinal Chemistry. 53:264-274
"Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes" (2012) Robaldo, L.;Izzo, F.;Dellafiore, M. (...)Iribarren, A.M. Bioorganic and Medicinal Chemistry. 20(8):2581-2586
"Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol" (2012) Lang, K.L.;Silva, I.T.;Zimmermann, L.A. (...)Durán, F.J. Marine Drugs. 10(10):2254-2264
"1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation" (2012) Avanzo, R.E.;Anesini, C.;Fascio, M.L. (...)D'Accorso, N.B. European Journal of Medicinal Chemistry. 47(1):104-110
"Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives" (2012) Lang, K.L.;Silva, I.T.;Zimmermann, L.A. (...)Durán, F.J. Bioorganic and Medicinal Chemistry. 20(9):3016-3030
"Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation" (2010) Lavaggi, M.L.;Cabrera, M.;Aravena, M.d.l.A. (...)Cerecetto, H. Bioorganic and Medicinal Chemistry. 18(12):4433-4440
"Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation" (2010) Lavaggi, M.L.;Cabrera, M.;Aravena, M.d.l.A. (...)Cerecetto, H. Bioorganic and Medicinal Chemistry. 18(12):4433-4440
"Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas" (2009) Labeur, M.; Paez-Pereda, M.; Arzt, E.; Stalla, G.K. Reviews in Endocrine and Metabolic Disorders. 10(2):103-109
"Invasive giant prolactinoma with loss of therapeutic response to cabergoline: Expression of angiogenic markers" (2009) Mallea-Gil, M.S.;Cristina, C.;Perez-Millan, M.I. (...)Becu-Villalobos, D. Endocrine Pathology. 20(1):35-40
"Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo" (2009) Schaaf, C.;Shan, B.;Buchfelder, M. (...)Renner, U. Endocrine-Related Cancer. 16(4):1339-1350
"Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts" (2009) Médici, R.; Iribarren, A.M.; Lewkowicz, E.S. Bioorganic and Medicinal Chemistry Letters. 19(15):4210-4212
"New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides." (2003) Rodríguez, J.B.; Comin, M.J. Mini reviews in medicinal chemistry. 3(2):95-114
"Roscovitine inhibits ongoing DNA synthesis in human cervical cancer" (2002) Vitali, L.;Yakisich, J.Sebastian;Vita, M.F. (...)Idoyaga Vargas, V. Cancer Letters. 180(1):7-12
"Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of β-lapachone" (2001) Di Chenna, P.H.;Benedetti-Doctorovich, V.;Baggio, R.F. (...)Burton, G. Journal of Medicinal Chemistry. 44(15):2486-2489
"Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri" (2001) Rodríguez Brasco, M.F.; Seldes, A.M.; Palermo, J.A. Organic Letters. 3(10):1415-1417
"Interferon-alpha 2b modulation of doxorubicin sensitivity in a multidrug resistant cell line" (2001) Gritti, M.F.L.; Beviacqua, M.; Bordenave, R.H.; Rumi, L.S. Journal of Experimental and Clinical Cancer Research. 20(3):393-400
"Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei" (2001) Maier, M.S.;Roccatagliata, A.J.;Kuriss, A. (...)Damonte, E.B. Journal of Natural Products. 64(6):732-736
"Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells" (2000) Páez Pereda, M.;Missale, C.;Grübler, Y. (...)Stalla, G.K. Molecular and Cellular Endocrinology. 167(1-2):99-106
"Reactivity of monoclonal antibody FC-2.15 against drug resistant breast cancer cells. Additive cytotoxicity of adriamycin and taxol with FC-2.15" (1998) Ballaré, C.;Portela, P.;Schiaffi, J. (...)Mordoh, J. Breast Cancer Research and Treatment. 47(2):163-170
"Indole alkaloids from the tunicate Aplidium meridianum" (1998) Franco, L.H.;De Kier Joffé, E.B.;Puricelli, L. (...)Palermo, J.A. Journal of Natural Products. 61(9):1130-1132
"Differentiating agents modulate topoisomerase I activity in U-937 promonocytic cells" (1997) Shayo, C.C.; Mladovan, A.G.; Baldi, A. European Journal of Pharmacology. 324(1):129-133
"Evaluation of the porphyrinogenic risk of antineoplastics" (1997) Cochón, A.C.; Aldonatti, C.; San Martín De Viale, L.C.; De Calmanovici, R.W. Journal of Applied Toxicology. 17(3):171-177
"Heparin receptors in two murine mammary adenocarcinomas with different metastatic ability: relationship with growth inhibition" (1995) Bertolesix, G.E.; de Cidre, L.L.; de Lustig, E.S.; Eiján, A.M. Cancer Letters. 90(2):123-131
"Effect of sulfation on the biological activity of β-(1→3)-glucans from the tree fungus Cyttaria harioti Fischer" (1989) Fernandez Cirelli, A.;Covian, J.A.;Ohno, N. (...)Yadomae, T. Carbohydrate Research. 190(2):329-337
"Effect of some antineoplasics on metabolic heme pathway" (1988) Wainstok De Calmanovici, R.; San Martin De Viale, L.C. International Journal of Biochemistry. 20(9):1015-1020
"Antitumoral activity of polysaccharide isolated from Cyttaria johowii on the growth of Sarcoma 180 in normal and splenectomized mice" (1986) Chasseing, N.A.; Lederkremer, R.; Couto, A.; Rumi, L.S. Acta Physiologica et Pharmacologica Latinoamericana. 36(1):29-38