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Curic, S.; Wu, Y.; Shan, B.; Schaaf, C.; Utpadel, D.; Lange, M.; Kuhlen, D.; Perone, M.J.; Arzt, E.; Stalla, G.K.; Renner, U. "Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas" (2013) Journal of Neuro-Oncology. 113(3):385-396
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Abstract:

Meningiomas, the most frequent benign intracranial and intraspinal types of tumors are normally removed by surgery. Complications can occur when the tumor is critically localized and cannot be completely removed or when comorbidities of the mostly elder patients increase the general surgical risk. Thus, alternate medical treatment concepts for the therapy of meningiomas would be desirable. Curcumin, the active ingredient of the spice plant Curcuma longa has shown anti-tumorigenic actions in many different types of tumors and therefore, its effect on growth and apoptosis of meningioma cells was studied in the present paper. In vitro, treatment of the human Ben-Men-1 meningioma cell line and of a series of 21 primary human meningioma cell cultures with curcumin (1-20 μM) strongly reduced the proliferation in all cases in a dose dependent manner. Cell cycle analysis by fluorescence-activated cell sorting showed growth arrest at G2/M phase, which was confirmed by demonstrating the corresponding modulation of proteins involved in G2/M arrest by immunoblotting and/or confocal laser microscopy. High dosages (20, 50 μM) of curcumin induced a significant increase of apoptosis in Ben-Men-1 and primary meningioma cell cultures as demonstrated by morphological changes of cell nuclei, DNA fragmentation, translocation of cell membrane associated phosphatidyl serine and the induction of apoptotic-acting cleaved caspase-3. Our results suggest that the multi-targeting drug curcumin has potent anti-tumorigenic actions in meningioma cells and might therefore be a putative candidate for the pharmacological treatment of meningiomas. © 2013 Springer Science+Business Media New York.

Registro:

Documento: Artículo
Título:Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas
Autor:Curic, S.; Wu, Y.; Shan, B.; Schaaf, C.; Utpadel, D.; Lange, M.; Kuhlen, D.; Perone, M.J.; Arzt, E.; Stalla, G.K.; Renner, U.
Filiación:Max Planck Institute of Psychiatry, Clinical Neuroendocrinology Group, Kraepelinstr. 10, 80804 Munich, Germany
Neurosurgical Department of the Clinic, Villingen-Schwenningen, Villingen-Schwenningen, Germany
Neurosurgical Clinic, Technical University Munich, Munichm, Germany
IBioBA-CONICET-Max Planck Partner Institute, Buenos Aires, Argentina
Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Apoptosis; Curcumin; G2/M phase cell cycle arrest; Meningioma; Proliferation; caspase 3; curcumin; phosphatidylserine; thymidine; antineoplastic agent; curcumin; adult; aged; antineoplastic activity; antiproliferative activity; apoptosis; article; cancer cell culture; cell cycle arrest; cell membrane; cell transport; concentration response; confocal laser microscopy; controlled study; DNA fragmentation; female; flow cytometry; fluorescence activated cell sorting; G2 phase cell cycle checkpoint; gene translocation; human; human cell; human tissue; immunoblotting; immunofluorescence test; in vitro study; male; meningioma; Western blotting; apoptosis; cell cycle; cell proliferation; drug effects; fluorescent antibody technique; meningioma; metabolism; pathology; tumor cell culture; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Curcumin; Flow Cytometry; Fluorescent Antibody Technique; Humans; Meningeal Neoplasms; Meningioma; Tumor Cells, Cultured
Año:2013
Volumen:113
Número:3
Página de inicio:385
Página de fin:396
DOI: http://dx.doi.org/10.1007/s11060-013-1148-9
Título revista:Journal of Neuro-Oncology
Título revista abreviado:J. Neuro-Oncol.
ISSN:0167594X
CODEN:JNODD
CAS:caspase 3, 169592-56-7; curcumin, 458-37-7; thymidine, 50-89-5; Antineoplastic Agents; Curcumin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0167594X_v113_n3_p385_Curic

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Citas:

---------- APA ----------
Curic, S., Wu, Y., Shan, B., Schaaf, C., Utpadel, D., Lange, M., Kuhlen, D.,..., Renner, U. (2013) . Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas. Journal of Neuro-Oncology, 113(3), 385-396.
http://dx.doi.org/10.1007/s11060-013-1148-9
---------- CHICAGO ----------
Curic, S., Wu, Y., Shan, B., Schaaf, C., Utpadel, D., Lange, M., et al. "Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas" . Journal of Neuro-Oncology 113, no. 3 (2013) : 385-396.
http://dx.doi.org/10.1007/s11060-013-1148-9
---------- MLA ----------
Curic, S., Wu, Y., Shan, B., Schaaf, C., Utpadel, D., Lange, M., et al. "Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas" . Journal of Neuro-Oncology, vol. 113, no. 3, 2013, pp. 385-396.
http://dx.doi.org/10.1007/s11060-013-1148-9
---------- VANCOUVER ----------
Curic, S., Wu, Y., Shan, B., Schaaf, C., Utpadel, D., Lange, M., et al. Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas. J. Neuro-Oncol. 2013;113(3):385-396.
http://dx.doi.org/10.1007/s11060-013-1148-9