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Maier, M.S.; Roccatagliata, A.J.; Kuriss, A.; Chludil, H.; Seldes, A.M.; Pujol, C.A.; Damonte, E.B. "Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei" (2001) Journal of Natural Products. 64(6):732-736
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Abstract:

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL.

Registro:

Documento: Artículo
Título:Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
Autor:Maier, M.S.; Roccatagliata, A.J.; Kuriss, A.; Chludil, H.; Seldes, A.M.; Pujol, C.A.; Damonte, E.B.
Filiación:Departamento de Química Orgánica, Facultad Ciencias Exactas Naturales, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Departamento de Química Biológica, Facultad Ciencias Exactas Naturales, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:antivirus agent; liouvilloside A; liouvilloside B; triterpene derivative; unclassified drug; antiviral activity; article; cytostasis; cytotoxicity; drug isolation; echinoderm; Herpes simplex virus 1; immunomodulation; structure analysis; sulfation; Animals; Antineoplastic Agents; Antiviral Agents; Carbohydrate Conformation; Cercopithecus aethiops; Drug Screening Assays, Antitumor; Herpesvirus 1, Human; Hydrolysis; Magnetic Resonance Spectroscopy; Methylation; Microbial Sensitivity Tests; Oligosaccharides; Sea Cucumbers; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes; Vero Cells
Año:2001
Volumen:64
Número:6
Página de inicio:732
Página de fin:736
DOI: http://dx.doi.org/10.1021/np000584i
Título revista:Journal of Natural Products
Título revista abreviado:J. Nat. Prod.
ISSN:01633864
CODEN:JNPRD
CAS:Antineoplastic Agents; Antiviral Agents; Oligosaccharides; Triterpenes; liouvilloside A; liouvilloside B
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v64_n6_p732_Maier

Referencias:

  • Stonik, V.A., Elyakov, G.B., Secondary Metabolites from Echinoderms as Chemotaxonomic Markers (1988) Bioorganic Marine Chemistry, 2, pp. 43-86. , Scheuer P. J., Ed.; Springer: Berlin
  • Kalinin, V.I., Volkova, O.V., Likhatskaya, G.N., Prokofieva, N.G., Agafonova, I.G., Anisimov, M.M., Kalinovsky, A.I., Stonik, V.A., (1992) J. Nat. Toxins, 1, pp. 31-37
  • Kalinin, V.I., Anisimov, M.M., Prokofieva, N.G., Avilov, S.A., Afiyatullov, Sh.Sh., Stonik, V.A., Biological activities and biological role of triterpene glycosides from holothuroidea (Echinodermata) (1996) Echinoderm Studies, 5, pp. 139-181. , Jangoux, M., Lawrence, J. M., Eds.; A. A. Balkema: Rotterdam
  • McKee, T.C., Cardellina, J.H., Riccio, R., D'Auria, M.V., Iorizzi, M., Minale, L., Moran, R.A., Boyd, M.R., (1994) J. Med. Chem., 37, pp. 793-797
  • Roccatagliata, A.J., Maier, M.S., Seldes, A.M., Pujol, C.A., Damonte, E.B., (1996) J. Nat. Prod., 59, pp. 887-889
  • Comin, M.J., Maier, M.S., Roccatagliata, A.J., Pujol, C.A., Damonte, E.B., (1999) Steroids, 64, pp. 335-340
  • Maier, M.S., Kuriss, A., Seldes, A.M., (1998) Lipids, 33, pp. 825-827
  • Roccatagliata, A.J., Maier, M.S., Seldes, A.M., (1998) J. Nat. Prod., 61, pp. 370-374
  • Avilov, S.A., Kalinovsky, A.I., Stonik, V.A., (1990) Khim. Prirod. Soedin, 1, pp. 53-57
  • Girard, M., Bélanger, J., ApSimon, J.W., Garneau, F.-X., Harvey, C., Brisson, J.-R., (1990) Can. J. Chem., 68, pp. 11-18
  • Breitmaier, E., Voelter, W., (1987) Carbon-13 NMR Spectroscopy, , VCH: Weinheim, Germany
  • Miyamoto, T., Togawa, K., Higuchi, R., Komori, T., Sasaki, T., (1990) Liebigs Ann. Chem., pp. 453-460
  • Cases, M.R., Cerezo, A.S., Stortz, C.A., (1995) Carbohydr. Res., 269, pp. 333-341
  • Drozdova, O.A., Avilov, S.A., Kalinovsky, A.I., Stonik, V.A., Milgrom, Y.M., Rashkes, Y.V., (1993) Khim. Prirod. Soedin, pp. 369-374
  • Avilov, S.A., Kalinovsky, A.I., Kalinin, V.I., Stonik, V.A., Riguera, R., Giménez, C., (1997) J. Nat. Prod., 60, pp. 808-810
  • Sietnick, A.J., De Bruyne, T., Apers, S., Pieters, L.A., (1998) Planta Med., 64, pp. 97-109
  • Simoes, C.M.O., Amoros, M., Schenkel, E.P., Shin-Kim, J.S., Rucker, G., Girre, L., (1990) Planta Med., 56, pp. 652-653
  • Simoes, C.M.O., Amoros, M., Girre, L., (1999) Phytother. Res., 13, pp. 323-328
  • Dargan, D.J., Subak-Sharpe, J.H., (1985) J. Gen. Virol., 66, pp. 1771-1784

Citas:

---------- APA ----------
Maier, M.S., Roccatagliata, A.J., Kuriss, A., Chludil, H., Seldes, A.M., Pujol, C.A. & Damonte, E.B. (2001) . Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei. Journal of Natural Products, 64(6), 732-736.
http://dx.doi.org/10.1021/np000584i
---------- CHICAGO ----------
Maier, M.S., Roccatagliata, A.J., Kuriss, A., Chludil, H., Seldes, A.M., Pujol, C.A., et al. "Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei" . Journal of Natural Products 64, no. 6 (2001) : 732-736.
http://dx.doi.org/10.1021/np000584i
---------- MLA ----------
Maier, M.S., Roccatagliata, A.J., Kuriss, A., Chludil, H., Seldes, A.M., Pujol, C.A., et al. "Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei" . Journal of Natural Products, vol. 64, no. 6, 2001, pp. 732-736.
http://dx.doi.org/10.1021/np000584i
---------- VANCOUVER ----------
Maier, M.S., Roccatagliata, A.J., Kuriss, A., Chludil, H., Seldes, A.M., Pujol, C.A., et al. Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei. J. Nat. Prod. 2001;64(6):732-736.
http://dx.doi.org/10.1021/np000584i