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Abstract:

Cushing's disease is a severe clinical condition caused by hypersecretion of corticosteroids due to excessive ACTH secretion from a pituitary adenoma. This complex endocrine disorder still represents a major challenge for the physician in terms of efficient treatment. In the last years there was only little progress in elucidating the molecular mechanisms responsible for the constitutive and autonomous ACTH secretion of pituitary corticotrophinomas. As a consequence, no effective drug therapy is currently available, particularly if surgical excision is not successful. In the present article we examine recent studies that have investigated the therapeutic potential of retinoic acid receptors as nuclear receptor targets for the treatment of Cushing's disease. Retinoic acid is an efficient drug used for the treatment of different types of cancers and it proved to act in animal models of Cushing's disease. The efficiency of this treatment in patients with this disorder still needs to be tested in clinical trials. © 2008 Springer Science+Business Media, LLC.

Registro:

Documento: Artículo
Título:Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas
Autor:Labeur, M.; Paez-Pereda, M.; Arzt, E.; Stalla, G.K.
Filiación:Max Planck Institute of Psychiatry, Munich, Germany
Affectis Pharmaceuticals, Munich, Germany
Lab. de Fisiología y Biología Molecular, FCEN, UBA, CONICET, Buenos Aires, Argentina
Palabras clave:Corticotrophinomas; Cushing's disease; Pituitary adenomas; Retinoic acid; Retinoic acid receptors; alitretinoin; alpha tocopherol; bexarotene; bone morphogenetic protein 4; cell nucleus receptor; corticosteroid; corticotropin; gamma interferon; isotretinoin; ketoconazole; paclitaxel; r 667; retinoic acid; retinoic acid derivative; retinoic acid receptor alpha; retinoic acid receptor beta; retinoic acid receptor gamma; retinoid X receptor; tazarotene; uab 30; unclassified drug; acne; ACTH secreting adenoma; actinic keratosis; alopecia areata; antineoplastic activity; atopic dermatitis; brain cancer; breast cancer; colorectal cancer; conjunctivitis; corticotropin release; Cushing disease; cutaneous T cell lymphoma; drug half life; drug intermittent therapy; drug mechanism; drug megadose; drug safety; drug targeting; emphysema; glioma; head and neck cancer; hormone action; human; hyperkeratosis; juvenile myelomonocytic leukemia; Kaposi sarcoma; kidney cancer; liver function; liver toxicity; lung non small cell cancer; lung small cell cancer; melanoma; mucosa inflammation; mycosis fungoides; nephroblastoma; neuroblastoma; nonhuman; photosensitivity; promyelocytic leukemia; prostate cancer; psoriasis; review; side effect; T cell leukemia; T cell lymphoma; teratogenicity; verruca vulgaris; ACTH-Secreting Pituitary Adenoma; Animals; Antineoplastic Agents; Humans; Pituitary ACTH Hypersecretion; Pituitary Neoplasms; Tretinoin
Año:2009
Volumen:10
Número:2
Página de inicio:103
Página de fin:109
DOI: http://dx.doi.org/10.1007/s11154-008-9080-6
Título revista:Reviews in Endocrine and Metabolic Disorders
Título revista abreviado:Rev. Endocr. Metab. Disord.
ISSN:13899155
CODEN:REMDC
CAS:alitretinoin, 5300-03-8; alpha tocopherol, 1406-18-4, 1406-70-8, 52225-20-4, 58-95-7, 59-02-9; bexarotene, 153559-49-0; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; gamma interferon, 82115-62-6; isotretinoin, 4759-48-2; ketoconazole, 65277-42-1; paclitaxel, 33069-62-4; retinoic acid, 302-79-4; tazarotene, 118292-40-3; Antineoplastic Agents; Tretinoin, 302-79-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13899155_v10_n2_p103_Labeur

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Citas:

---------- APA ----------
Labeur, M., Paez-Pereda, M., Arzt, E. & Stalla, G.K. (2009) . Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas. Reviews in Endocrine and Metabolic Disorders, 10(2), 103-109.
http://dx.doi.org/10.1007/s11154-008-9080-6
---------- CHICAGO ----------
Labeur, M., Paez-Pereda, M., Arzt, E., Stalla, G.K. "Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas" . Reviews in Endocrine and Metabolic Disorders 10, no. 2 (2009) : 103-109.
http://dx.doi.org/10.1007/s11154-008-9080-6
---------- MLA ----------
Labeur, M., Paez-Pereda, M., Arzt, E., Stalla, G.K. "Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas" . Reviews in Endocrine and Metabolic Disorders, vol. 10, no. 2, 2009, pp. 103-109.
http://dx.doi.org/10.1007/s11154-008-9080-6
---------- VANCOUVER ----------
Labeur, M., Paez-Pereda, M., Arzt, E., Stalla, G.K. Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas. Rev. Endocr. Metab. Disord. 2009;10(2):103-109.
http://dx.doi.org/10.1007/s11154-008-9080-6