Artículo

Páez Pereda, M.; Missale, C.; Grübler, Y.; Arzt, E.; Schaaf, L.; Stalla, G.K. "Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells" (2000) Molecular and Cellular Endocrinology. 167(1-2):99-106
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Abstract:

NGF has anti-proliferative and anti-invasive effects in neuroendocrine tumors. In the present work we examined the effects of NGF and retinoic acid on cell proliferation and invasion in thyroid carcinoma cells. We found that NGF and retinoic acid do not affect cell proliferation on their own but in combination they produce a strong inhibition. We also found that retinoic acid regulates the matrix metalloproteinase 2 activity and invasion. In contrast, NGF inhibited invasion and reverted the effect of retinoic acid. This effect of NGF is likely mediated by an increase in adhesion to laminin and collagen IV and the inhibition of cell migration. NGF also induced the expression of the p75 NGF receptor. In conclusion, NGF and retinoic acid in combination inhibit proliferation and invasion of thyroid papillary carcinoma cells. These data open the possibility of a potential combined therapy for thyroid papillary carcinomas. (C) 2000 Elsevier Science Ireland Ltd.

Registro:

Documento: Artículo
Título:Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells
Autor:Páez Pereda, M.; Missale, C.; Grübler, Y.; Arzt, E.; Schaaf, L.; Stalla, G.K.
Filiación:Max Planck Institute of Psychiatry, Dept. Endocrinol., K., Munich, Germany
Dept. of Biomed. Sci. and Biotech., Div. Pharmacol., Univ. Brescia, V., Brescia, Italy
Lab. of Physiol. and Molec. Biology, Dept. Biol., FCEN, Univ. Buenos A., Buenos Aires, Argentina
Palabras clave:Invasion; Nerve growth factor; Retinoic acid; Thyroid papillary carcinoma; collagen type 4; gelatinase A; laminin; nerve growth factor; retinoic acid; article; cancer cell culture; cancer inhibition; cancer invasion; cell adhesion; controlled study; drug mechanism; drug potency; drug potentiation; enzyme regulation; human; human cell; metastasis inhibition; priority journal; thyroid papillary carcinoma; Antineoplastic Agents; Carcinoma, Papillary; Cell Adhesion; Cell Division; Cell Movement; Gelatinase A; Human; Neoplasm Invasiveness; Nerve Growth Factor; Receptor, Nerve Growth Factor; Support, Non-U.S. Gov't; Thyroid Neoplasms; Tretinoin; Tumor Cells, Cultured
Año:2000
Volumen:167
Número:1-2
Página de inicio:99
Página de fin:106
DOI: http://dx.doi.org/10.1016/S0303-7207(00)00286-0
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:gelatinase A, 146480-35-5; laminin, 2408-79-9; nerve growth factor, 9061-61-4; retinoic acid, 302-79-4; Antineoplastic Agents; Gelatinase A, EC 3.4.24.24; Nerve Growth Factor, 9061-61-4; Receptor, Nerve Growth Factor; Tretinoin, 302-79-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v167_n1-2_p99_PaezPereda

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Citas:

---------- APA ----------
Páez Pereda, M., Missale, C., Grübler, Y., Arzt, E., Schaaf, L. & Stalla, G.K. (2000) . Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells. Molecular and Cellular Endocrinology, 167(1-2), 99-106.
http://dx.doi.org/10.1016/S0303-7207(00)00286-0
---------- CHICAGO ----------
Páez Pereda, M., Missale, C., Grübler, Y., Arzt, E., Schaaf, L., Stalla, G.K. "Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells" . Molecular and Cellular Endocrinology 167, no. 1-2 (2000) : 99-106.
http://dx.doi.org/10.1016/S0303-7207(00)00286-0
---------- MLA ----------
Páez Pereda, M., Missale, C., Grübler, Y., Arzt, E., Schaaf, L., Stalla, G.K. "Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells" . Molecular and Cellular Endocrinology, vol. 167, no. 1-2, 2000, pp. 99-106.
http://dx.doi.org/10.1016/S0303-7207(00)00286-0
---------- VANCOUVER ----------
Páez Pereda, M., Missale, C., Grübler, Y., Arzt, E., Schaaf, L., Stalla, G.K. Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells. Mol. Cell. Endocrinol. 2000;167(1-2):99-106.
http://dx.doi.org/10.1016/S0303-7207(00)00286-0