Artículo

Lang, K.L.; Silva, I.T.; Zimmermann, L.A.; Lhullier, C.; Arana, M.V.M.; Palermo, J.A.; Falkenberg, M.; Simões, C.M.O.; Schenkel, E.P.; Durán, F.J. "Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol" (2012) Marine Drugs. 10(10):2254-2264
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Abstract:

In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate. The structural elucidation of the new derivatives was based on detailed NMR and MS spectroscopic analyses. The in vitro cytotoxicity of compounds 1 to 8 was evaluated against A459 and RD tumor cell lines with CC50 values ranging from 4.93 to 41.53 μM. These results suggest that the structural modifications performed on both compounds could be considered a good strategy to obtain more active derivatives. © 2012 by the authors; licensee MDPI, Basel, Switzerland.

Registro:

Documento: Artículo
Título:Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol
Autor:Lang, K.L.; Silva, I.T.; Zimmermann, L.A.; Lhullier, C.; Arana, M.V.M.; Palermo, J.A.; Falkenberg, M.; Simões, C.M.O.; Schenkel, E.P.; Durán, F.J.
Filiación:Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-970, Brazil
Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA, Argentina
Palabras clave:Cytotoxic activity; Elatol; Isoobtusol; Sesquiterpenes; Synthesis; cytotoxic agent; elatol 9 carbamate; elatol 9 hemisuccinate; elatol 9 sulfamate; elatol derivative; hydroxyl group; isoobtusol 9 carbamate; isoobtusol 9 hemisuccinate; isoobtusol 9 sulfamate; isoobtusol derivative; unclassified drug; article; cancer cell culture; chemical modification; concentration response; controlled study; drug cytotoxicity; drug structure; embryo; human; human cell; in vitro study; mass spectrometry; nuclear magnetic resonance; rhabdomyosarcoma; Antineoplastic Agents; Cell Line; Humans; Laurencia; Molecular Structure; Spiro Compounds
Año:2012
Volumen:10
Número:10
Página de inicio:2254
Página de fin:2264
DOI: http://dx.doi.org/10.3390/md10102254
Título revista:Marine Drugs
Título revista abreviado:Mar. Drugs
ISSN:16603397
CODEN:MDARE
CAS:Antineoplastic Agents; Spiro Compounds; elatol, 55303-97-4; isoobtusol, 73494-23-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16603397_v10_n10_p2254_Lang

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Citas:

---------- APA ----------
Lang, K.L., Silva, I.T., Zimmermann, L.A., Lhullier, C., Arana, M.V.M., Palermo, J.A., Falkenberg, M.,..., Durán, F.J. (2012) . Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol. Marine Drugs, 10(10), 2254-2264.
http://dx.doi.org/10.3390/md10102254
---------- CHICAGO ----------
Lang, K.L., Silva, I.T., Zimmermann, L.A., Lhullier, C., Arana, M.V.M., Palermo, J.A., et al. "Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol" . Marine Drugs 10, no. 10 (2012) : 2254-2264.
http://dx.doi.org/10.3390/md10102254
---------- MLA ----------
Lang, K.L., Silva, I.T., Zimmermann, L.A., Lhullier, C., Arana, M.V.M., Palermo, J.A., et al. "Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol" . Marine Drugs, vol. 10, no. 10, 2012, pp. 2254-2264.
http://dx.doi.org/10.3390/md10102254
---------- VANCOUVER ----------
Lang, K.L., Silva, I.T., Zimmermann, L.A., Lhullier, C., Arana, M.V.M., Palermo, J.A., et al. Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol. Mar. Drugs. 2012;10(10):2254-2264.
http://dx.doi.org/10.3390/md10102254