Artículo

Shan, B.; Schaaf, C.; Schmidt, A.; Lucia, K.; Buchfelder, M.; Losa, M.; Kuhlen, D.; Kreutzer, J.; Perone, M.J.; Arzt, E.; Stalla, G.K.; Renner, U. "Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas" (2012) Journal of Endocrinology. 214(3):389-398
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Abstract:

Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (nZ32) studied. Under hypoxia-mimicking conditions (CoCl 2 treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (nZ8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesis and secretion ofVEGFAinGH3 cells and in all human pituitary adenoma cell cultures investigated (nZ18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated antiproliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation. © 2012 Society for Endocrinology.

Registro:

Documento: Artículo
Título:Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
Autor:Shan, B.; Schaaf, C.; Schmidt, A.; Lucia, K.; Buchfelder, M.; Losa, M.; Kuhlen, D.; Kreutzer, J.; Perone, M.J.; Arzt, E.; Stalla, G.K.; Renner, U.
Filiación:Neuroendocrinology Group, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
Department of Neurosurgery, University of Erlangen-Nuremburg, Schwabachanlage 6, 91594 Erlangen, Germany
Department of Neurosurgery, Istituto San Raffaele, Via Olgettina 60, 20132 Milano, Italy
Department of Neurosurgery, Technical University Munich, Ismaninger Straße 22, 81675 Munich, Germany
Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiologi y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
IBioBA-CONICET, Max Planck Partner Institute, RA-1428 Buenos Aires, Argentina
Palabras clave:curcumin; hypoxia inducible factor 1alpha; messenger RNA; vasculotropin; vasculotropin A; adult; aged; angiogenesis; animal cell; article; female; human; human cell; hypophysis adenoma; in vitro study; male; nonhuman; priority journal; protein secretion; protein synthesis; rat; reverse transcription polymerase chain reaction; Western blotting; Adenoma; Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Corticotrophs; Curcumin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lactotrophs; Mice; Neovascularization, Pathologic; Pituitary Neoplasms; Rats; RNA, Messenger; Somatotrophs; Vascular Endothelial Growth Factor A
Año:2012
Volumen:214
Número:3
Página de inicio:389
Página de fin:398
DOI: http://dx.doi.org/10.1530/JOE-12-0207
Título revista:Journal of Endocrinology
Título revista abreviado:J. Endocrinol.
ISSN:00220795
CODEN:JOENA
CAS:curcumin, 458-37-7; vasculotropin, 127464-60-2; vasculotropin A, 489395-96-2; Antineoplastic Agents; Curcumin, 458-37-7; HIF1A protein, human; Hypoxia-Inducible Factor 1, alpha Subunit; RNA, Messenger; VEGFA protein, human; Vascular Endothelial Growth Factor A
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220795_v214_n3_p389_Shan

Referencias:

  • Abdel-Haq, H., Giacomelli, S., Palmery, M., Leone, M.G., Saso, L., Silvestrini, B., Aflatoxins inhibit prolactin secretion by rat pituitary cells in culture (2000) Drug and Chemical Toxicology, 23, pp. 381-386
  • Asa, S.L., Ezzat, S., The pathogenesis of pituitary tumors (2009) Annual Review of Pathology, 4, pp. 97-126
  • Bae, M.K., Kim, S.H., Jeong, J.W., Lee, Y.M., Kim, H.S., Kim, S.R., Yun, I., Kim, K.W., Curcumin inhibits hypoxia-induced angiogenesis via down- regulation of HIF-1 (2006) Oncology Reports, 15, pp. 1557-1562
  • Bangaru, M.L., Woodliff, J., Raff, H., Kansra, S., Growth suppression of mouse pituitary corticotroph tumor AtT20 cells by curcumin: a model for treating Cushing's disease (2010) PLoS ONE, 5, pp. e9893
  • Bradford, M.M., A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding (1976) Analytical Biochemistry, 72, pp. 248-254
  • Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G.K., Holsboer, F., Arzt, E., RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia (2007) Cell, 131, pp. 309-323
  • Carmeliet, P., Angiogenesis in health and disease (2003) Nature Medicine, 9, pp. 653-660
  • Carmeliet, P., VEGF as a key mediator of angiogenesis in cancer (2005) Oncology, 69, pp. 4-10
  • Choi, H., Chun, Y.S., Kim, S.W., Kim, M.S., Park, J.W., Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition (2006) Molecular Pharmacology, 70, pp. 1664-1671
  • Colao, A., Savastano, S., Medical treatment of prolactinomas (2011) Nature Reviews. Endocrinology, 7, pp. 267-278
  • Ebert, B.L., Bunn, H.F., Regulation of the erythropoietin gene (1999) Blood, 94, pp. 1864-1877
  • Farnoud, M.R., Kujas, M., Derome, P., Racadot, J., Peillon, F., Li, J.Y., Interactions between normal and tumoral tissues at the boundary of human pituitary adenomas (1994) Virchows Archiv: an International Journal of Pathology, 424, pp. 75-82
  • Ferrara, N., Vascular endothelial growth factor: basic science and clinical progress (2004) Endocrine Reviews, 25, pp. 581-611
  • Giustina, A., Bronstein, M.D., Casanueva, F.F., Chanson, P., Ghigo, E., Ho, K.K., Klibanski, A., Melmed, S., Current management practices for acromegaly: an international survey (2011) Pituitary, 14, pp. 125-133
  • Gloddek, J., Pagotto, U., Paez-Pereda, M., Arzt, E., Stalla, G.K., Renner, U., Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells (1999) Journal of Endocrinology, 160, pp. 483-490
  • Gospodarowicz, D., Abraham, J.A., Schilling, J., Isolation and characterization of a vascular cell mitogen produced by pituitary-derived folliculo stellate cells (1989) PNAS, 6, pp. 7311-7315
  • Gupta, S.C., Kim, J.H., Prasad, S., Aggarwal, B.B., Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals (2010) Cancer and Metastasis Reviews, 29, pp. 405-434
  • Gupta, S.C., Prasad, S., Kim, J.H., Patchva, S., Webb, L.J., Priyardasini, I.K., Aggarwal, B.B., Multitargeting by curcumin as revealed by molecular interaction studies (2011) Natural Product Reports, 28, pp. 1937-1955
  • Harris, A.L., Hypoxia - a key regulatory factor in tumour growth (2002) Nature Reviews. Cancer, 2, pp. 38-47
  • Hickey, M.M., Simon, M.C., Regulation of angiogenesis by hypoxia and hypoxia-inducible factors (2006) Current Topics in Developmental Biology, 76, pp. 217-257
  • Hori, S., Hayashi, N., Fukuoda, J., Kurimoto, M., Hamada, H., Miyajima, K., Nagai, S., Endo, S., Folliculostellate cell tumor in the pituitary gland (2009) Neuropathology, 29, pp. 78-80
  • Iwaki, T., Kondo, A., Takeshita, I., Nakagaki, H., Kitamura, K., Tateishi, J., Proliferating potential of folliculo-stellate cells in human pituitary adenomas, Immunohistochemical and electron microscopic analysis (1986) Acta Neuropathologica, 71, pp. 233-242
  • Jung, H.J., Kim, J.H., Shim, J.S., Kwon, H.J., A novel Ca2C/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor (2010) Journal of Biological Chemistry, 285, pp. 25867-25874
  • Kim, K., Yoshida, D., Teramoto, A., Expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in pituitary adenomas (2005) Endocrine Pathology, 16, pp. 115-121
  • Kunnumakkara, A.B., Anand, P., Aggarwal, B.B., Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins (2008) Cancer Letters, 269, pp. 199-225
  • Lafont, C., Desarmenien, M.G., Cassou, M., Molino, F., Lecoq, J., Hodson, D., Lacampagne, A., Carmignac, D., Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function (2010) PNAS, 107, pp. 4465-4470
  • Lloyd, R.V., Scheithauer, B.W., Kuroki, T., Vidal, S., Kovacs, K., Stefaneanu, L., Vascular endothelial growth factor (VEGF) expression in human pituitary adenomas and carcinomas (1999) Endocrine Pathology, 10, pp. 229-235
  • Lohrer, P., Gloddek, J., Hopfner, U., Losa, M., Uhl, E., Pagotto, U., Stalla, G.K., Renner, U., Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro (2001) Neuroendocrinology, 7, pp. 95-105
  • Masson, N., Ratcliffe, P.J., HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels (2003) Journal of Cell Science, 116, pp. 3041-3049
  • Melmed, S., Pathogenesis of pituitary tumors (2011) Nature Reviews. Endocrinology, 7, pp. 257-266
  • Miller, M., Chen, S., Woodliff, J., Kansra, S., Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells (2008) Endocrinology, 149, pp. 4158-4167
  • Nagasawa, H., The in vitro and in vivo effects of dimethyl sulfoxide on the pituitary secretion of growth hormone and prolactin in mice (1983) Annals of the New York Academy of Sciences, 411, pp. 34-42
  • Onofri, C., Theodoropoulou, M., Losa, M., Uhl, E., Lange, M., Arzt, E., Stalla, G.K., Renner, U., Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours (2006) Journal of Endocrinology, 191, pp. 249-261
  • Pagotto, U., Arzberger, T., Theodoropoulou, M., Grübler, Y., Pantaloni, C., Saeger, W., Losa, M., Spengler, D., The expression of the antiproliferative gene ZAC is lost or highly reduced in non-functioning pituitary adenomas (2000) Cancer Research, 60, pp. 6794-6799
  • Perez-Castro, C., Renner, U., Haedo, M.R., Stalla, G.K., Arzt, E., Cellular and molecular specificity of pituitary gland physiology (2012) Physiological Reviews, 92, pp. 1-38
  • Raverot, G., Sturm, N., de Fraipont, F., Muller, M., Salenave, S., Caron, P., Chabre, O., Assaker, R., Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience (2010) Journal of Clinical Endocrinology and Metabolism, 95, pp. 4592-4599
  • Renner, U., Arzberger, T., Pagotto, U., Leingruber, S., Uhl, E., Müller, A., Lange, M., Stalla, G.K., Heterogeneous dopamine D2 receptor subtype messenger ribonucleic acid expression in clinically non-functioning pituitary adenomas (1998) Journal of Clinical Endocrinology and Metabolism, 83, pp. 1368-1375
  • Renner, U., Lohrer, P., Schaaf, L., Feirer, M., Schmitt, K., Onofri, C., Arzt, E., Stalla, G.K., Transforming growth factor-β stimulates vascular endothelial growth factor production by folliculostellate pituitary cells (2002) Endocrinology, 143, pp. 3759-3765
  • Renner, U., Paez-Pereda, M., Arzt, E., Stalla, G.K., Growth factors and cytokines: function and molecular regulation in pituitary adenomas (2004) Frontiers of Hormone Research, 32, pp. 96-109
  • Saeger, W., Lüdecke, D.K., Buchfelder, M., Fahlbusch, R., Quabbe, H.J., Petersenn, S., Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry (2007) European Journal of Endocrinology, 156, pp. 203-216
  • Santos, N.C., Figueira-Coelho, J., Martins-Silva, J., Saldanha, C., Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects (2003) Biochemical Pharmacology, 65, pp. 1035-1041
  • Schaaf, C., Shan, B., Buchfelder, M., Losa, M., Kreutzer, J., Rachinger, W., Stalla, G.K., Perone, M.J., Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo (2009) Endocrine-Related Cancer, 16, pp. 1339-1350
  • Schaaf, C., Shan, B., Onofri, C., Stalla, G.K., Arzt, E., Schilling, T., Perone, M.J., Renner, U., Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells (2010) Neuroendocrinology, 91, pp. 200-210
  • Shahani, K., Swaminathan, S.K., Freeman, D., Blum, A., Ma, L., Panyam, J., Injectable sustained release microparticles of curcumin: a new concept for cancer prevention (2010) Cancer Research, 70, pp. 4443-4452
  • Shan, B., Gerez, J., Haedo, M., Fuertes, M., Theodoropoulou, M., Buchfelder, M., Losa, M., Renner, U., RSUME is implicated in HIF-1-induced VEGFA production in pituitary tumour cells (2012) Endocrine-Related Cancer, 19, pp. 13-27
  • Shehzad, A., Wahid, F., Lee, Y.S., Curcumin in cancer prevention: molecular targets, pharmacokinetics, bioavailability, and clinical targets (2010) Archiv der Pharmazie, 9, pp. 489-499
  • Shih, S.C., Claffey, K.P., Role of AP-1 and HIF-1 transcription factors in TGF-β activation of VEGF expression (2001) Growth Factors, 19, pp. 19-34
  • Ströfer, M., Jelkmann, W., Depping, R., Curcumin decreases survival of Hep3B liver and MCF-7 breast cancer cells (2011) The role of HIF. Strahlentherapie und Onkologie, 187, pp. 393-400
  • Thomas, S.L., Zhong, D., Zhou, W., Malik, S., Liotta, D., Snyder, J.P., Hamel, E., Giannakakou, P., EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1 (2008) Cell Cycle, 7, pp. 2409-2417
  • Turner, H.E., Nagy, Z., Gatter, K.C., Esiri, M.M., Harris, A.L., Wass, J., Angiogenesis in pituitary adenomas and the normal pituitary gland (2000) Journal of Clinical Endocrinology and Metabolism, 85, pp. 1159-1162
  • Viacava, P., Gasperi, M., Acerbi, G., Manetti, L., Cecconi, E., Bonadio, A.G., Naccarato, A.G., Lupi, I., Microvascular density and vascular endothelial growth factor expression in normal pituitary tissue and pituitary adenomas (2003) Journal of Endocrinological Investigation, 26, pp. 23-28
  • Vidal, S., Horvath, E., Kovacs, K., Kuroki, T., Lloyd, R.V., Scheithauer, B.W., Expression of hypoxia-inducible factor-1α (HIF-1α) in pituitary tumours (2003) Histology and Histopathology, 18, pp. 679-686
  • Wahl, O., Oswald, M., Tretzel, L., Herres, E., Arend, J., Efferth, T., Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products (2011) Current Medicinal Chemistry, 18, pp. 3136-3155
  • Webb, J.D., Coleman, M.L., Pugh, C.W., Hypoxia, hypoxia-inducible factors (HIF) (2009) HIF hydroxylases and oxygen sensing. Cellular and Molecular Life Sciences, 66, pp. 3539-3554
  • Wei, W., Yu, X.D., Hypoxia-inducible factors: cross-talk between their protein stability and protein degradation (2007) Cancer Letters, 257, pp. 145-156
  • Yadav, V.R., Aggarwal, B.B., Curcumin: a component of the golden spice, targets multiple angiogenic pathways (2011) Cancer Biology & Therapy, 11, pp. 236-241
  • Yuan, Y., Hilliard, G., Ferguson, T., Millhorn, D.E., Cobalt inhibits the interaction between hypoxia-inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-α (2003) Journal of Biological Chemistry, 278, pp. 15911-15916

Citas:

---------- APA ----------
Shan, B., Schaaf, C., Schmidt, A., Lucia, K., Buchfelder, M., Losa, M., Kuhlen, D.,..., Renner, U. (2012) . Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas. Journal of Endocrinology, 214(3), 389-398.
http://dx.doi.org/10.1530/JOE-12-0207
---------- CHICAGO ----------
Shan, B., Schaaf, C., Schmidt, A., Lucia, K., Buchfelder, M., Losa, M., et al. "Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas" . Journal of Endocrinology 214, no. 3 (2012) : 389-398.
http://dx.doi.org/10.1530/JOE-12-0207
---------- MLA ----------
Shan, B., Schaaf, C., Schmidt, A., Lucia, K., Buchfelder, M., Losa, M., et al. "Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas" . Journal of Endocrinology, vol. 214, no. 3, 2012, pp. 389-398.
http://dx.doi.org/10.1530/JOE-12-0207
---------- VANCOUVER ----------
Shan, B., Schaaf, C., Schmidt, A., Lucia, K., Buchfelder, M., Losa, M., et al. Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas. J. Endocrinol. 2012;214(3):389-398.
http://dx.doi.org/10.1530/JOE-12-0207