Abstract:
Five new indole alkaloids, meridianins A-E (1-5), have been isolated from the tunicate Aplidium meridianum, which was collected at a depth of 100 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Compounds 2-5 showed cytotoxicity toward murine tumor cell lines.
Registro:
Documento: |
Artículo
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Título: | Indole alkaloids from the tunicate Aplidium meridianum |
Autor: | Franco, L.H.; De Kier Joffé, E.B.; Puricelli, L.; Tatian, M.; Seldes, A.M.; Palermo, J.A. |
Filiación: | Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina Inst. de Oncol. A. H. Roffo, Av. San Martín 5481, (1417) Buenos Aires, Argentina Cátedra de Anat. Comparada, Fac. de Cie. Exact., Fis. y Nat., Univ. Nacional de Córdoba, Av. Vélez Sarsfield 299, (5000) Córdoba, Argentina
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Palabras clave: | alkaloid; indole derivative; meridianin; meridianin b; meridianin c; meridianin d; meridianin e; unclassified drug; article; carbon nuclear magnetic resonance; drug cytotoxicity; drug isolation; drug structure; invertebrate; marine environment; nonhuman; proton nuclear magnetic resonance; tumor cell; Alkaloids; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured; Urochordata; Aplidium; Aplidium meridianum; Invertebrata; Murinae |
Año: | 1998
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Volumen: | 61
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Número: | 9
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Página de inicio: | 1130
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Página de fin: | 1132
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DOI: |
http://dx.doi.org/10.1021/np970493u |
Título revista: | Journal of Natural Products
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Título revista abreviado: | J. Nat. Prod.
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ISSN: | 01633864
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CODEN: | JNPRD
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CAS: | Alkaloids; Antineoplastic Agents
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n9_p1130_Franco |
Referencias:
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Citas:
---------- APA ----------
Franco, L.H., De Kier Joffé, E.B., Puricelli, L., Tatian, M., Seldes, A.M. & Palermo, J.A.
(1998)
. Indole alkaloids from the tunicate Aplidium meridianum. Journal of Natural Products, 61(9), 1130-1132.
http://dx.doi.org/10.1021/np970493u---------- CHICAGO ----------
Franco, L.H., De Kier Joffé, E.B., Puricelli, L., Tatian, M., Seldes, A.M., Palermo, J.A.
"Indole alkaloids from the tunicate Aplidium meridianum"
. Journal of Natural Products 61, no. 9
(1998) : 1130-1132.
http://dx.doi.org/10.1021/np970493u---------- MLA ----------
Franco, L.H., De Kier Joffé, E.B., Puricelli, L., Tatian, M., Seldes, A.M., Palermo, J.A.
"Indole alkaloids from the tunicate Aplidium meridianum"
. Journal of Natural Products, vol. 61, no. 9, 1998, pp. 1130-1132.
http://dx.doi.org/10.1021/np970493u---------- VANCOUVER ----------
Franco, L.H., De Kier Joffé, E.B., Puricelli, L., Tatian, M., Seldes, A.M., Palermo, J.A. Indole alkaloids from the tunicate Aplidium meridianum. J. Nat. Prod. 1998;61(9):1130-1132.
http://dx.doi.org/10.1021/np970493u