Artículo
Careaga, V.P.; Bueno, C.; Muniain, C.; Alché, L.; Maier, M.S. "Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus" (2014) Natural Product Research. 28(4):213-220
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Abstract:
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2013 Taylor & Francis.
Registro:
| Documento: | Artículo |
| Título: | Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
| Autor: | Careaga, V.P.; Bueno, C.; Muniain, C.; Alché, L.; Maier, M.S. |
| Filiación: | Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina Laboratorio de Ecología Química y Biodiversidad Acuática, Instituto de Investigación e Ingeniería Ambiental, Universidad Nacional de San Martín, Peatonal Belgrano 3563 1, 1650 San-Martín, Buenos Aires, Argentina |
| Palabras clave: | antiproliferative; cytotoxic; Pseudocnus dubiosus leoninus; sulphated triterpene glycosides; glycoside; hemoiedemosides a; patagonicosides b; pseudocnoside a; triterpene; unclassified drug; antiproliferative activity; article; cancer cell culture; carbon nuclear magnetic resonance; controlled study; drug structure; Hemioedema spectabilis_ib drug isolation; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; human; human cell; nonhuman; nuclear magnetic resonance spectroscopy; nuclear Overhauser effect; proton nuclear magnetic resonance; Pseudocnus dubiosus leoninus; sea cucumber; Holothuroidea; Pseudocnus dubiosus; Psolus; Animals; Antineoplastic Agents; Atlantic Ocean; Drug Screening Assays, Antitumor; Glycosides; HeLa Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sea Cucumbers; Triterpenes |
| Año: | 2014 |
| Volumen: | 28 |
| Número: | 4 |
| Página de inicio: | 213 |
| Página de fin: | 220 |
| DOI: | http://dx.doi.org/10.1080/14786419.2012.751596 |
| Título revista: | Natural Product Research |
| Título revista abreviado: | Nat. Prod. Res. |
| ISSN: | 14786419 |
| CODEN: | NPRAA |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14786419_v28_n4_p213_Careaga |
Referencias:
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Citas:
---------- APA ----------
Careaga, V.P., Bueno, C., Muniain, C., Alché, L. & Maier, M.S. (2014) . Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus. Natural Product Research, 28(4), 213-220.http://dx.doi.org/10.1080/14786419.2012.751596
---------- CHICAGO ----------
Careaga, V.P., Bueno, C., Muniain, C., Alché, L., Maier, M.S. "Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus" . Natural Product Research 28, no. 4 (2014) : 213-220.http://dx.doi.org/10.1080/14786419.2012.751596
---------- MLA ----------
Careaga, V.P., Bueno, C., Muniain, C., Alché, L., Maier, M.S. "Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus" . Natural Product Research, vol. 28, no. 4, 2014, pp. 213-220.http://dx.doi.org/10.1080/14786419.2012.751596
---------- VANCOUVER ----------
Careaga, V.P., Bueno, C., Muniain, C., Alché, L., Maier, M.S. Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus. Nat. Prod. Res. 2014;28(4):213-220.http://dx.doi.org/10.1080/14786419.2012.751596
