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Abstract:

matrix presented In the course of our search of new bioactive metabolites from marine invertebrates, paesslerins A and B, sesquiterpenoids with an unprecedented tricyclic skeleton, were isolated from the subAntarctic soft coral Alcyonium paessleri collected at a depth of 200 m near the South Georgia islands, and their structures were elucidated by spectroscopic techniques. These compounds show moderate cytotoxicity in preliminary assays.

Registro:

Documento: Artículo
Título:Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri
Autor:Rodríguez Brasco, M.F.; Seldes, A.M.; Palermo, J.A.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pab. 2, (1428) Buenos Aires, Argentina
Palabras clave:antineoplastic agent; biological factor; bridged compound; paesslerin A; paesslerin B; sesquiterpene; animal; article; biology; cell culture; chemistry; coelenterate; drug effect; human; isolation and purification; manpower; Animals; Antineoplastic Agents; Biological Factors; Bridged Compounds; Cnidaria; Humans; Marine Biology; Sesquiterpenes; Tumor Cells, Cultured
Año:2001
Volumen:3
Número:10
Página de inicio:1415
Página de fin:1417
DOI: http://dx.doi.org/10.1021/ol006684x
Título revista:Organic Letters
Título revista abreviado:Org. Lett.
ISSN:15237060
CAS:Antineoplastic Agents; Biological Factors; Bridged Compounds; paesslerin A; paesslerin B; Sesquiterpenes
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15237060_v3_n10_p1415_RodriguezBrasco

Referencias:

  • Palermo, J.A., Rodríguez Brasco, M.F., Spagnuolo, C., Seldes, A.M., (2000) J. Org. Chem., 65, pp. 4482-4486
  • Hall, D.R., Beevor, P.S., Campion, D.G., Chamberlain, D.J., Cork, A., White, R.D., Almestar, A., Henneberry, T., (1992) J. Tetrahedron Lett., 33, pp. 4811-4814
  • Cimino, G., De Giulio, A., De Rosa, S., De Stefano, S., (1989) Tetrahedron, 45, pp. 6479-6484

Citas:

---------- APA ----------
Rodríguez Brasco, M.F., Seldes, A.M. & Palermo, J.A. (2001) . Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri. Organic Letters, 3(10), 1415-1417.
http://dx.doi.org/10.1021/ol006684x
---------- CHICAGO ----------
Rodríguez Brasco, M.F., Seldes, A.M., Palermo, J.A. "Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri" . Organic Letters 3, no. 10 (2001) : 1415-1417.
http://dx.doi.org/10.1021/ol006684x
---------- MLA ----------
Rodríguez Brasco, M.F., Seldes, A.M., Palermo, J.A. "Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri" . Organic Letters, vol. 3, no. 10, 2001, pp. 1415-1417.
http://dx.doi.org/10.1021/ol006684x
---------- VANCOUVER ----------
Rodríguez Brasco, M.F., Seldes, A.M., Palermo, J.A. Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium Paessleri. Org. Lett. 2001;3(10):1415-1417.
http://dx.doi.org/10.1021/ol006684x