Artículo
Rodríguez, J.B.; Comin, M.J. "New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides." (2003) Mini reviews in medicinal chemistry. 3(2):95-114
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Abstract:
The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological importance such as: reverse transcriptase, adenosine deaminase, thymidine kinase, DNA cytosine-C5 methyl transferase, S-adenosylhomocysteine hydrolase, etc are considered. The role of conformation and puckering of the glycon moiety in modulating the biological activity and also the use of carbanucleosides as building blocks to prepare oligonucleotides are carefully illustrated.
Registro:
| Documento: | Artículo |
| Título: | New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. |
| Autor: | Rodríguez, J.B.; Comin, M.J. |
| Filiación: | Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Argentina |
| Palabras clave: | 2',3' dideoxynucleoside derivative; alkanone; anti human immunodeficiency virus agent; antineoplastic agent; carbovir; cyclohexane derivative; cyclopentane derivative; cyclopropane derivative; glyceraldehyde; glycoside; nucleoside; chemistry; conformation; cyclization; human; review; stereoisomerism; synthesis; Anti-HIV Agents; Antineoplastic Agents; Butanones; Cyclization; Cyclohexanes; Cyclopentanes; Cyclopropanes; Dideoxynucleosides; Glyceraldehyde; Glycosides; Humans; Molecular Conformation; Nucleosides; Stereoisomerism |
| Año: | 2003 |
| Volumen: | 3 |
| Número: | 2 |
| Página de inicio: | 95 |
| Página de fin: | 114 |
| DOI: | http://dx.doi.org/10.2174/1389557033405331 |
| Título revista: | Mini reviews in medicinal chemistry |
| Título revista abreviado: | Mini Rev Med Chem |
| ISSN: | 13895575 |
| CAS: | carbovir, 118353-05-2; glyceraldehyde, 367-47-5; Anti-HIV Agents; Antineoplastic Agents; Butanones; carbovir, 118353-05-2; Cyclohexanes; Cyclopentanes; Cyclopropanes; Dideoxynucleosides; Glyceraldehyde, 367-47-5; Glycosides; Nucleosides |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895575_v3_n2_p95_Rodriguez |
Citas:
---------- APA ----------
Rodríguez, J.B. & Comin, M.J. (2003) . New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. Mini reviews in medicinal chemistry, 3(2), 95-114.http://dx.doi.org/10.2174/1389557033405331
---------- CHICAGO ----------
Rodríguez, J.B., Comin, M.J. "New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides." Mini reviews in medicinal chemistry 3, no. 2 (2003) : 95-114.http://dx.doi.org/10.2174/1389557033405331
---------- MLA ----------
Rodríguez, J.B., Comin, M.J. "New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides." Mini reviews in medicinal chemistry, vol. 3, no. 2, 2003, pp. 95-114.http://dx.doi.org/10.2174/1389557033405331
---------- VANCOUVER ----------
Rodríguez, J.B., Comin, M.J. New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. Mini Rev Med Chem. 2003;3(2):95-114.http://dx.doi.org/10.2174/1389557033405331
