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Referencias:

• Chen, Z., Fillmore, C.M., Hammerman, P.S., Kim, C.F., Wong, K.-K., Non-small cell lung cancers: a heterogeneous set of diseases (2014) Nat. Rev. Cancer, 14, pp. 535-546
• Siegel, R.L., Miller, K.D., Jemal, A., Cancer Statistics, 2015 (2015) Ca-Cancer J. Clin., 65, pp. 5-29
• Koh, P.K., Faivre-Finn, C., Blackhall, F.H., De Ruysscher, D., Targeted agents in non-small cell lung cancer (NSCLC): Clinical developments and rationale for the combination with thoracic radiotherapy (2012) Cancer Treat. Rev., 38, pp. 626-640
• Ríos, I., Andújar, J.M., Escandell, R.M., Recio, M.C., Cucurbitacins as inducers of cell death and a rich source of potential cancer compounds (2012) Curr. Pharm. Des., 18, pp. 1663-1676
• Chen, X., Bao, J., Guo, J., Ding, Q., Lu, J., Huang, M., Wang, Y., Biological activities and potential molecular targets of cucurbitacins: a focus on cancer (2012) Anti-Cancer Drugs, 23, pp. 777-787
• Silva, I.T., Carvalho, A., Lang, K.L., Dudek, S.E., Durán, F.J., Caro, M.S.B., Rapp, U.R., Ludwig, S., In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B (2015) PLoS One, 10, pp. 1-19
• Lang, K.L., Guimarães, T., Machado, V.R., Zimmermann, L., Silva, I.T., Teixeira, M.R., Durán, F.J., Schenkel, E.P., New cytotoxic cucurbutacins from Wilbrandia ebracteata Cogn (2011) Planta Med., 77, pp. 1648-1651
• Lang, K., Silva, I.T., Zimmermann, L., Machado, V.R., Teixeira, M.R., Lapuh, M.I., Galleti, M.A., Durán, F.J., Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives (2012) Bioorg. Med. Chem., 20, pp. 3016-3030
• Lang, K.L., Silva, I.T., Machado, V.R., Zimmermann, L., Caro, M.S.B., Simões, C.M.O., Schenkel, E.P., Melo, E.B., Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line (2014) J. Mol. Graphics Modell., 48, pp. 70-79
• Silva, I.T., Teixeira, M.R., Lang, K., Guimarães, T.R., Dudek, S.E., Durán, F.J., Ludwig, S., Simões, C.M.O., Proliferative inhibition and apoptotic mechanism on human non-small-cell lung cancer (A549 cells) of a novel cucurbitacin from Wilbrandia ebracteata Cogn (2013) Int. J. Cancer Res., 9, pp. 54-68
• Thoennissen, N.H., Iwanski, G.B., Doan, N.B., Okamoto, R., Lin, P., Abbassi, S., Song, J.H., Koeffler, P., Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells (2009) Cancer Res., 69, pp. 5876-5884
• Liu, T., Peng, H., Zhang, M., Deng, Y., Wu, Z., Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin (2010) Eur. J. Pharmacol., 641, pp. 15-22
• Chen, W., Leiter, A., Yin, D., Meiring, M., Louw, V., Koeffler, H.P., Cucurbitacin B inhibits growth, arrest the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines (2010) Int. J. Oncol., 37, pp. 737-743
• Iwanski, G.B., Lee, D., En-Gal, S., Doan, N.B., Castor, B., Vogt, M., Toh, M., Koeffler, P., Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer (2010) Br. J. Pharmacol., 160, pp. 998-1007
• Martinelli, E., Troiani, T., Morgillo, F., Rodolico, G., Vitagliano, D., Pia Morelli, M., Tuccillo, C., Ciardiello, F., Synergistic antitumor activity of Sorafenib in combination with Epidermal Growth Factor Receptor inhibitors in colorectal and lung cancer cells (2010) Clin. Cancer Res., 16, pp. 4990-5001
• Li, C.J., Chu, C., Huang, L., Wang, M., Sheu, L., Yeh, J., Hsu, H., Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo (2012) Cancer Lett., 319, pp. 203-213
• Hatakeyama, Y., Kobayashi, K., Nagano, T., Tamura, D., Yamamoto, M., Tachihara, M., Kotani, Y., Nishimura, Y., Synergistic effects of pemetrexed and amrubicin in non-small cell lung cancer cell lines (2014) Cancer Lett., 343, pp. 74-79
• Duangmano, S., Sae-Lim, P., Suksamrarn, A., Patmasiriwat, P., Domman, F.E., Cucurbitacin B causes increased radiation sensitivity of human breast cancer cells via G2/M cell cycle arrest (2012) J. Oncol., 2012, pp. 1-8
• Chang, C.-J., Chiang, C.-H., Song, W.-S., Tsai, S.-K., Woung, L.-C., Chang, C.-H., Jeng, S.-Y., Lu, K.-H., Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells (2012) Childs Nerv. Syst., 28, pp. 363-373
• Aribi, A., Gery, S., Lee, D.H., Thoennissen, N.H., Thoennissen, G.B., Alvarez, R., Ho, Q., Koeffler, H.P., The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer (2013) Int. J. Cancer, 132, pp. 2730-2737
• Qu, Y., Wu, X., Yin, Y., Yang, Y., Ma, D., Li, H., Antitumor activity of selective MEK 1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models (2014) J. Exp. Clin. Cancer Res., 33, p. 52
• Vichai, V., Kirtikara, K., Sulforhodamine B colorimetric assay for cytotoxicity screening (2006) Nat. Protoc., 1, pp. 1112-1116
• Larsson, J., Gottfries, J., Muresan, S., Backlund, A., ChemGPS-NP: Tuned for navigation in biologically relevant chemical space (2007) J. Nat. Prod., 70, pp. 789-794
• Felth, J., Rickardson, L., Rosén, J., Wickstrom, M., Fryknas, M., Lindskog, M., Bohlin, L., Gullbo, J., Cytotoxic Effects of Cardiac Glycosides in Colon Cancer Cells, Alone and in Combination with Standard Chemotherapeutic Drugs (2009) J. Nat. Prod., 72, pp. 1969-1974
• Chou, T.C., Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies (2006) Pharmacol. Rev., 58 (3), pp. 621-681
• Franken, N.A.P., Rodermond, H.M., Stap, J., Haveman, J., Van Bree, C., Clonogenic assay of cells in vitro (2006) Nat. Protoc., 1, pp. 2315-2319
• Riccardi, C., Nicoletti, I., Analysis of apoptosis by propidium iodide staining and flow cytometry (2006) Nat. Protoc., 1, pp. 1458-1461
• Selinummi, J., Seppala, J., Yli-Harja, O., Puhakka, J.A., Software for quantification of labeled bacteria from digital microscope images by automated image analysis (2005) BioTechniques, 39, pp. 859-862
• Custodio, A., Méndez, M., Provencio, M., Targeted therapies for advanced non-small-cell lung cancer: current status and future implications (2012) Cancer Treat. Rev., 38, pp. 36-53
• Rosén, J., Lövgren, A., Kogej, T., Muresan, S., Gottfries, J., Backlund, A., ChemGPS NPWeb: chemical space navigation online (2009) J. Comput.-Aided Mol. Des., 23, pp. 253-259
• Rosén, J., Rickardson, L., Backlund, A., Gullbo, J., Bohlin, L., Larsson, R., Gottfries, J., ChemGPS-NP mapping of chemical compounds for prediction of anticancer mode of action (2009) QSAR Comb. Sci., 28, pp. 436-446
• Lee, C., Lin, Y., Chang, F., Chen, G., Backlund, A., Yang, J., Chen, Y., Wu, Y., Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors (2012) PLoS One, 7, pp. 1-14
• Kausar, H., Munagala, R., Bansal, S.S., Aqil, F., Vadhanan, M.V., Gupta, R.C., Cucurbitacin B potently suppresses non-small-cell lung cancer growth: Identification of intracellular thiols as critical targets (2013) Cancer Lett., 332, pp. 35-45
• Guo, J., Wu, G., Bao, J., Hao, W., Lu, J., Chen, X., Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner (2014) PLoS One, 9, pp. 1-12
• Andriani, F., Perego, P., Roz, L., Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after FHIT gene transfer (2006) Neoplasia, 8, pp. 9-17
• Kaufmann, S.H., Peereboom, D., Buckwalter, C.A., Swingen, P.A., Grochow, L.B., Donehower, R.C., Rowinsky, E.K., Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines (1996) J. Natl. Cancer Inst., 88, pp. 734-741
• Odonkor, C.A., Achilefu, S., Differential activity of caspase-3 regulates susceptibility of lung and breast tumor cell lines to paclitaxel (2008) Open Biochem. J., 2, pp. 121-128
• Zhu, J.S., Ouyang, D.Y., Shi, Z.J., Xu, L.H., Zhang, Y.T., He, X.H., Cucurbitacin B Induces Cell Cycle Arrest, Apoptosis and Autophagy Associated with G Actin Reduction and Persistent Activation of Cofilin in Jurkat Cells (2012) Pharmacology, 89, pp. 348-356
• Duangmano, S., Sae-Lim, P., Suksamrarn, A., Patmasiriwat, P., Domman, F.E., Cucurbitacin B causes increased radiation sensitivity of human breast cancer cells via G2/M cell cycle arrest (2012) J. Oncol., 2012, pp. 1-8
• Yasuda, S., Yogosawa, S., Izutani, Y., Nakamura, Y., Watanabe, H., Sakai, T., Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells (2010) Mol. Nutr. Food Res., 54, pp. 559-565
• Huang, W., Yang, J., Lin, M., Chen, P., Chiou, S., Chueh, F., Lan, Y., Chung, J., Cucurbitacin E Induces G2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells (2012) Evid-Based Compl. Alt., 2012, pp. 1-11
• Zhu, J.S., Ouyang, D.Y., Shi, Z.J., Xu, L.H., Zhang, Y.T., He, X.H., Cucurbitacin B Induces Cell Cycle Arrest, Apoptosis and Autophagy Associated with G Actin Reduction and Persistent Activation of Cofilin in Jurkat Cells (2012) Pharmacology, 89, pp. 348-356
• Haritunians, T., Gueller, S., Zhang, L., Badr, R., Yin, D., Xing, H., Fung, M.C., Koeffler, P., Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells (2008) Leuk. Res., 32, pp. 1366-1373
• Knecht, D.A., LaFleur, R.A., Kahsai, A.W., Argueta, C.E., Beshir, A.B., Fenteany, G., Cucurbitacin I Inhibits Cell Motility by Indirectly Interfering with Actin Dynamics (2010) PLoS One, 5, pp. 1-11
• Zhang, T., Li, Y., Park, K.A., Byun, H.S., Won, M., Jeon, J., Lee, Y., Hur, G.M., Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis (2012) Autophagy, 8, pp. 559-576
• Park, S., Kim, J., Chi, G., Kim, G., Chang, Y., Moon, S., Nam, S., Choi, Y., Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species (2012) Toxicol. Lett., 212, pp. 252-261
• Gabrielsen, M., Schuldt, M., Munro, J., Borucka, D., Cameron, J., Baugh, M., Mleczak, A., Olson, M., Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target (2013) Cell Commun. Signaling, 11, p. 58
• Blaschuk, O.W., Devemy, E., Cadherins as novel targets for anticancer therapy (2009) Eur. J. Pharmacol., 625, pp. 195-198
• Shanmugam, M.K., Nguyen, A.H., Kumar, A.P., Tan, B.K.H., Sethi, G., Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer (2012) Cancer Lett., 320, pp. 158-170
• Zhang, T., Li, J., Dong, Y., Zhai, D., Lai, L., Dai, F., Deng, H., Yi, M., Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion (2012) Breast Cancer Res. Treat., 135, pp. 445-458
• Deryugina, E.I., Quigley, J.P., Matrix Metalloproteinases and tumor metastasis (2006) Cancer Metastasis Rev., 25, pp. 9-34
• Muller, C.B., Barros, R.L.S., Castro, M.A.A., Lopes, F.M., Meurer, R.T., Roehe, A., Mazzini, G., Klamt, F., Validation of cofilin-1 as a biomarker in non-small cell lung cancer: application of quantitative method in a retrospective cohort (2011) J. Cancer Res. Clin. Oncol., 137, pp. 1309-1316
• Nakashima, S., Matsuda, H., Kurume, A., Oda, Y., Nakamura, S., Yamashita, M., Yoshikawa, M., Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells (2010) Bioorg. Med. Chem. Lett., 20, pp. 2994-2997
• Zhang, Y.-T., Ouyang, D.-Y., Xu, L.-H., Zha, Q.-B., He, X.-H., Formation of Cofilin-Actin rods following cucurbitacin-B-induced aggregation depends on slingshot Homolog1-Mediated Cofilin Hyperactivation (2013) J. Cell. Biochem., 114, pp. 2415-2429
• Siveen, K.S., Sikka, S., Surana, R., Dai, X., Zhang, J., Kumar, A.P., Tan, B.K.H., Bishayee, A., Targeting the Stat3 signaling pathway in cancer: Role of synthetic and natural inhibitors (2014) Biochim. Biophys. Acta, Rev. Cancer, 1845, pp. 136-154

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