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antineoplastic activity

"Adjuvants in cutaneous melanoma patients: Long term antitumor immunity and short term release of acute inflammatory reactants" (2018) Pampena, M.B.;Cartar, H.C.;Cueto, G.R. (...)Mordoh, J. Frontiers in Immunology. 9(NOV)

"Targeting the mitochondrial VDAC in hepatocellular carcinoma using a polyclonal antibody-conjugated to a nitrosyl ruthenium complex" (2018) Ramos, L.C.B.;Rodrigues, F.P.;Biazzotto, J.C. (...)da Silva, R.S. Journal of Biological Inorganic Chemistry. 23(6):903-916

"Immunotherapy in cancer. Current prospects, challenges and new horizons. " (2018) Dalotto-Moreno, T.;Blidner, A.G.;Girotti, M.R. (...)Rabinovich, G.A. Medicina (Argentina). 78(5):336-348

"In vivo hemin conditioning targets the vascular and immunologic compartments and restrains prostate tumor development" (2017) Jaworski, F.M.;Gentilini, L.D.;Gueron, G. (...)Vazquez, E.S. Clinical Cancer Research. 23(17):5135-5148

"Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model" (2017) Marostica, L.L.;de Barros, A.L.B.;Oliveira, J. (...)Simões, C.M.O. Toxicology and Applied Pharmacology. 329:272-281

"Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides" (2017) Avanzo, R.E.; Padrón, J.M.; D'Accorso, N.B.; Fascio, M.L. Bioorganic and Medicinal Chemistry Letters. 27(16):3674-3677

"The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients" (2017) Colado, A.;Almejún, M.B.;Podaza, E. (...)Borge, M. Cancer Immunology, Immunotherapy. 66(4):461-473

"Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells" (2017) Basso, A.V.;Leiva González, S.;Barboza, G.E. (...)Nicotra, V.E. Chemistry and Biodiversity. 14(8)

"Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer" (2016) Blidner, A.G.; Mariño, K.V.; Rabinovich, G.A. Immunity. 44(6):1248-1250

"Biological relevance of Hsp90-binding immunophilins in cancer development and treatment" (2016) Mazaira, G.I.;Camisay, M.F.;De Leo, S. (...)Galigniana, M.D. International Journal of Cancer. 138(4):797-808

"In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B" (2015) Silva, I.T.;Carvalho, A.;Lang, K.L. (...)Ludwig, S. PLoS ONE. 10(2)

"Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties" (2015) Fascio, M.L.; Errea, M.I.; D'Accorso, N.B. European Journal of Medicinal Chemistry. 90:666-683

"The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor" (2015) Casa, A.J.;Hochbaum, D.;Sreekumar, S. (...)Lee, A.V. Molecular and Cellular Endocrinology. 415:76-86

"Low doses of CPS49 and flavopiridol combination as potential treatment for advanced prostate cancer" (2015) Zalazar, F.;De Luca, P.;Gardner, K. (...)De Siervi, A. Current Pharmaceutical Biotechnology. 16(6):553-563

"Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments" (2015) Blidner, A.G.;Salatino, M.;Mascanfroni, I.D. (...)Rabinovich, G.A. Journal of Immunology. 194(7):3452-3462

"Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases" (2014) Wan, X.;Corn, P.G.;Yang, J. (...)Navone, N.M. Science Translational Medicine. 6(252)

"Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line" (2014) Lang, K.L.;Silva, I.T.;Machado, V.R. (...)De Melo, E.B. Journal of Molecular Graphics and Modelling. 48:70-79

"QSAR on antiproliferative naphthoquinones based on a conformation- independent approach" (2014) Duchowicz, P.R.;Bennardi, D.O.;Bacelo, D.E. (...)Misico, R.I. European Journal of Medicinal Chemistry. 77:176-184

"Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents" (2014) Sonego, J.M.;Rivero, E.M.;Gargiulo, L. (...)Burton, G. European Journal of Medicinal Chemistry. 82:233-241

"Evaluation of cytotoxic activity of cucurbitacins and their semisynthetic derivatives" (2014) Da-Silva, I.T.;Carvalho, A.;Lang, K.L. (...)Ludwig, S. Vitae. 21:S25

"Chemical constituents and biological activity of euglena gracilis extracts" (2013) Tolivia, A.; Conforti, V.; Córdoba, O.; Flores, L. Journal of Pharmacy Research. 7(3):209-214

"Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas" (2013) Curic, S.;Wu, Y.;Shan, B. (...)Renner, U. Journal of Neuro-Oncology. 113(3):385-396

"Antitumor activity of histamine and clozapine in a mouse experimental model of human melanoma" (2013) Massari, N.A.;Medina, V.A.;Cricco, G.P. (...)Rivera, E.S. Journal of Dermatological Science. 72(3):252-262

"Anti-tumor effect of SLPI on mammary but not colon tumor growth" (2013) Amiano, N.O.;Costa, M.J.;Reiteri, R.M. (...)Chuluyan, H.E. Journal of Cellular Physiology. 228(2):469-475

"1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation" (2012) Avanzo, R.E.;Anesini, C.;Fascio, M.L. (...)D'Accorso, N.B. European Journal of Medicinal Chemistry. 47(1):104-110

"Management of cytoskeleton architecture by molecular chaperones and immunophilins" (2011) Quintá, H.R.;Galigniana, N.M.;Erlejman, A.G. (...)Galigniana, M.D. Cellular Signalling. 23(12):1907-1920

"H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1" (2011) Ibañez, I.L.;Policastro, L.L.;Tropper, I. (...)Durán, H. Cancer Letters. 305(1):58-68

"Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from laminaria saccharina brown seaweed" (2011) Croci, D.O.;Cumashi, A.;Ushakova, N.A. (...)Nifantiev, N.E. PLoS ONE. 6(2)

"Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells" (2010) Schaaf, C.;Shan, B.;Onofri, C. (...)Renner, U. Neuroendocrinology. 91(2):200-210

"Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation" (2010) Lavaggi, M.L.;Cabrera, M.;Aravena, M.d.l.A. (...)Cerecetto, H. Bioorganic and Medicinal Chemistry. 18(12):4433-4440

"Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo" (2009) Schaaf, C.;Shan, B.;Buchfelder, M. (...)Renner, U. Endocrine-Related Cancer. 16(4):1339-1350

"Potential of retinoic acid derivatives for the treatment of corticotroph pituitary adenomas" (2009) Labeur, M.; Paez-Pereda, M.; Arzt, E.; Stalla, G.K. Reviews in Endocrine and Metabolic Disorders. 10(2):103-109

"Reduced glioma growth following dexamethasone or anti-angiopoietin 2 treatment" (2008) Villeneuve, J.;Galarneau, H.;Beaudet, M.-J. (...)Vallières, L. Brain Pathology. 18(3):401-414

"Cellular inactivation and antitumor efficacy of a new zinc phthalocyanine with potential use in photodynamic therapy" (2008) Vittar, N.B.R.;Prucca, C.G.;Strassert, C. (...)Rivarola, V.A. International Journal of Biochemistry and Cell Biology. 40(10):2192-2205

"Nucleoside phosphorylases" (2006) Lewkowicz, E.S.; Iribarren, A.M. Current Organic Chemistry. 10(11):1197-1215

"Development of β-Lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels" (2005) Reinicke, K.E.;Bey, E.A.;Bentle, M.S. (...)Boothman, D.A. Clinical Cancer Research. 11(8):3055-3064

"Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of β-lapachone" (2001) Di Chenna, P.H.;Benedetti-Doctorovich, V.;Baggio, R.F. (...)Burton, G. Journal of Medicinal Chemistry. 44(15):2486-2489

"Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters" (2000) Palermo, J.A.; Brasco, M.F.R.; Spagnuolo, C.; Seldes, A.M. Journal of Organic Chemistry. 65(15):4482-4486

"New spiranoid withanolides from Jaborosa odonelliana" (2000) Cirigliano, A.M.; Veleiro, A.S.; Oberti, J.C.; Burton, G. Molecules. 5(3):441-442

"An improved microbial synthesis of purine nucleosides" (2000) Lewkowicz, E.S.;Martínez, N.;Rogert, M.C. (...)Iribarren, A.M. Biotechnology Letters. 22(16):1277-1280

"Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice" (1998) Gerez, E.; Vazquez, E.; Caballero, F.; Del C Batlle, A.M. European Journal of Cancer Prevention. 7(4):337-342

"Reactivity of monoclonal antibody FC-2.15 against drug resistant breast cancer cells. Additive cytotoxicity of adriamycin and taxol with FC-2.15" (1998) Ballaré, C.;Portela, P.;Schiaffi, J. (...)Mordoh, J. Breast Cancer Research and Treatment. 47(2):163-170

"16-hydroxylated withanolides from Exodeconus maritimus" (1997) Gil, R.R.;Misico, R.I.;Sotes, I.R. (...)Burton, G. Journal of Natural Products. 60(6):568-572

"Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana" (1994) Pomilio, A.B.; Rutty Solá, G.A.; Mayer, A.M.S.; Rumi, L.S. Journal of Ethnopharmacology. 44(1):25-33

"Synthesis and antitumor activity of anthracycline disaccharide glycosides containing daunosamine" (1993) Horton, D.; Priebe1, W.; Sznaidmanc, M.L.; Varela, O. Journal of Antibiotics. 46(11):1720-1730

"Antitumor screening of Gomphrena species" (1991) Pomilio, A.B.; Buschi, C.A.; Rutty Sola, G.A.; Rumi, L.S. Fitoterapia. 62(6):511-514