Abstract:
Hepatocarcinogenesis (HC) induced by various carcinogens such as 1,4- dimethylaminoazobenzene (DAB) is a multistep and complex process. The anticancer efficacy of β-carotene (βC) was evaluated by estimating some biochemical parameters during the initiation stage of HC. βC dietary supplementation partially prevented the rise in δ-aminolevulinate synthetase activity. P 450 levels were dramatically enhanced in all groups studied. βC administration did not overcome catalase inactivation due to DAB treatment; however, superoxide dismutase activity levels showed to be less decreased in the DAB + βC animals in comparison to the DAB group. The great enhancement provoked by DAB of glutathione S-transferase, a proposed marker of HC, was partially reversed by βC. In conclusion, heme pathway regulation, drug metabolism, and natural oxidative defence systems, strikingly modified in DAB fed animals, were partially controlled by provitamin A. The potential use of βC in preventing carcinogenesis is suggested.
Registro:
Documento: |
Artículo
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Título: | Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice |
Autor: | Gerez, E.; Vazquez, E.; Caballero, F.; Del C Batlle, A.M. |
Filiación: | Ctro. Invest. Sobre Porfirinas P., Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina Viamonte 1881 10o A, 1056 Buenos Aires, Argentina
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Palabras clave: | β-carotene; 1,4-dimethylaminoazobenzene; Drug metabolizing system; Heme metabolism; Hepatocarcinogenesis; Oxidative stress; 4 dimethylaminoazobenzene; alpha carotene; beta carotene; catalase; cytochrome p450; superoxide dismutase; transferase; tumor marker; animal experiment; animal model; animal tissue; antineoplastic activity; article; cancer control; diet supplementation; dietary intake; drug metabolism; enzyme inactivation; liver carcinogenesis; mouse; nonhuman; oxidative stress; priority journal; Animals; Antioxidants; beta Carotene; Carcinogens; Drug Antagonism; Male; Mice; Neoplasms, Experimental; p-Dimethylaminoazobenzene |
Año: | 1998
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Volumen: | 7
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Número: | 4
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Página de inicio: | 337
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Página de fin: | 342
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DOI: |
http://dx.doi.org/10.1097/00008469-199808000-00010 |
Título revista: | European Journal of Cancer Prevention
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Título revista abreviado: | Eur.J. Cancer Prev.
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ISSN: | 09598278
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CODEN: | EJUPE
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CAS: | Antioxidants; beta Carotene, 7235-40-7; Carcinogens; p-Dimethylaminoazobenzene, 60-11-7
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n4_p337_Gerez |
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Citas:
---------- APA ----------
Gerez, E., Vazquez, E., Caballero, F. & Del C Batlle, A.M.
(1998)
. Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice. European Journal of Cancer Prevention, 7(4), 337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010---------- CHICAGO ----------
Gerez, E., Vazquez, E., Caballero, F., Del C Batlle, A.M.
"Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice"
. European Journal of Cancer Prevention 7, no. 4
(1998) : 337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010---------- MLA ----------
Gerez, E., Vazquez, E., Caballero, F., Del C Batlle, A.M.
"Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice"
. European Journal of Cancer Prevention, vol. 7, no. 4, 1998, pp. 337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010---------- VANCOUVER ----------
Gerez, E., Vazquez, E., Caballero, F., Del C Batlle, A.M. Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice. Eur.J. Cancer Prev. 1998;7(4):337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010