Navegar

Colección

Datos Estadísticas

Artículo

La versión final de este artículo es de uso interno de la institución.
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Hepatocarcinogenesis (HC) induced by various carcinogens such as 1,4- dimethylaminoazobenzene (DAB) is a multistep and complex process. The anticancer efficacy of β-carotene (βC) was evaluated by estimating some biochemical parameters during the initiation stage of HC. βC dietary supplementation partially prevented the rise in δ-aminolevulinate synthetase activity. P 450 levels were dramatically enhanced in all groups studied. βC administration did not overcome catalase inactivation due to DAB treatment; however, superoxide dismutase activity levels showed to be less decreased in the DAB + βC animals in comparison to the DAB group. The great enhancement provoked by DAB of glutathione S-transferase, a proposed marker of HC, was partially reversed by βC. In conclusion, heme pathway regulation, drug metabolism, and natural oxidative defence systems, strikingly modified in DAB fed animals, were partially controlled by provitamin A. The potential use of βC in preventing carcinogenesis is suggested.

Registro:

Documento: Artículo
Título:Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice
Autor:Gerez, E.; Vazquez, E.; Caballero, F.; Del C Batlle, A.M.
Filiación:Ctro. Invest. Sobre Porfirinas P., Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina
Viamonte 1881 10o A, 1056 Buenos Aires, Argentina
Palabras clave:β-carotene; 1,4-dimethylaminoazobenzene; Drug metabolizing system; Heme metabolism; Hepatocarcinogenesis; Oxidative stress; 4 dimethylaminoazobenzene; alpha carotene; beta carotene; catalase; cytochrome p450; superoxide dismutase; transferase; tumor marker; animal experiment; animal model; animal tissue; antineoplastic activity; article; cancer control; diet supplementation; dietary intake; drug metabolism; enzyme inactivation; liver carcinogenesis; mouse; nonhuman; oxidative stress; priority journal; Animals; Antioxidants; beta Carotene; Carcinogens; Drug Antagonism; Male; Mice; Neoplasms, Experimental; p-Dimethylaminoazobenzene
Año:1998
Volumen:7
Número:4
Página de inicio:337
Página de fin:342
DOI: http://dx.doi.org/10.1097/00008469-199808000-00010
Título revista:European Journal of Cancer Prevention
Título revista abreviado:Eur.J. Cancer Prev.
ISSN:09598278
CODEN:EJUPE
CAS:Antioxidants; beta Carotene, 7235-40-7; Carcinogens; p-Dimethylaminoazobenzene, 60-11-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n4_p337_Gerez

Referencias:

  • Blakely, S., Slaughter, L., Adkins, J., Knight, E., Effects of beta-carotene and retinyl palmitate on the corn oil induced superoxide dismutase and catalase in rats (1988) J Nutr, 118, pp. 152-158
  • Chance, B., Maehly, A., Assay of catalases and peroxidases (1955) Methods Enzymol, pp. 764-768. , (eds Chance E, Maehly A); Academic Press, New York
  • El-Mouelhi, M., Didolkar, M., Elias, E., Guengerich, F., Kauffman, F., Hepatic drug metabolizing enzymes in primary and secondary tumors of human liver (1987) Cancer Res, 47, pp. 460-466
  • Farber, E., Precancerous steps in carcinogenesis -their physiological adaptive nature (1984) Biochim Biophys Acta, 138, pp. 171-180
  • Gerez, E., Vazquez, E., Caballero, F., Polo, C., Batlle, A., Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis. Effect of veronal (1997) Gen Pharmac, 29, pp. 569-573
  • Habig, W., Pabst, M., Jakoby, W., Glutathione S-transferases. The first enzymatic step in mercapturic acid formation (1974) J Biol Chem, 249, pp. 7130-7139
  • Hathcock, J., Hattan, D., Jenkins, M., McDonald, J., Sundaresan, P., Wilkening, V., Evaluation of vitamin a toxicity (1990) Am J Clin Nutr, 52, pp. 183-202
  • Knox, W., L-tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver) (1970) Methods Enzymol, 17, pp. 415-417
  • Lawrence, R., Burk, R., Glutathione peroxidase activity in selenium-deficient rat liver (1976) Biochem Biophys Res Commun, 71, pp. 952-958
  • Lowry, O., Rosebrough, N., Farr, A., Randall, R., Protein measurement with the Folin-phenol reagent (1951) J Biol Chem, 193, pp. 265-275
  • Marver, H., Tschudy, D., Perlroth, M., Collins, A., δ-aminolevulinic acid synthetase. I. Studies in liver homogenates (1966) J Biol Chem, 241, pp. 2803-2809
  • Miller, A., Diet, nutrition and cancer: An epidemiological overview (1985) J Nutr Growth Cancer, 2, pp. 159-171
  • Moreno, F., Rizzi, M., Dagil, M., Penteado, M., Inhibitory effects of β-carotene on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model (1991) Carcinogenesis, 12, pp. 1817-1822
  • Moreno, F., Wu, T., Penteado, M., Rizzi, M., Jordao Jr., A., Almeida-Muradian, L., Dagli, M., A comparison of beta-carotene and vitamin a effects on a hepatocarcinogenesis model (1995) Int J Vitamin Nutr Res, 65, pp. 87-94
  • Niehaus, W., Samuelson, B., Formation of malon-aldehyde from phospholipids arachidonate during microsomal lipid peroxidation (1968) Eur J Biochem, 6, pp. 126-130
  • Omura, T., Sato, R., The carbon monoxide binding pigment of liver microsomes (1964) J Biol Chem, 239, pp. 2370-2378
  • Paoletti, F., Aldinucci, D., Mocall, A., Caparrini, A., A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts (1986) Anal Biochem, 154, pp. 536-541
  • Pinto, R., Bartley, W., The effect of age and sex on glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates (1969) Biochem J, 112, pp. 109-115
  • Polo, C., Vazquez, E., Caballero, F., Gerez, E., Batlle, A., Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation (1992) Comp Biochem Physiol, 103 B, pp. 251-256
  • Sarkar, A., Mukherjee, B., Chatterjee, M., Inhibitory effect of β-carotene on chronic 2-acetylaminofluorene induced hepatocarcinogenesis in rat: Reflection in hepatic drug metabolism (1994) Carcinogenesis, 15, pp. 1055-1060
  • Sato, K., Glutathione transferases as markers of preneoplasia and neoplasia (1990) Adv Cancer Res, 52, pp. 205-255
  • Yoshida, T., Kikuchi, G., Purification and properties of heme oxygenase from pig spleen microsomes (1978) J Biol Chem, 253, pp. 4224-4229
  • Zeigler, R., A review of epidemiologic evidence that the carotenoids reduce the risk of cancer (1989) J Nutr, 119, pp. 116-122
  • Zhang, L., Cooney, R., Bertram, J., Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer chemopreventive action (1991) Carcinogenesis, 12, pp. 2109-2114

Citas:

---------- APA ----------
Gerez, E., Vazquez, E., Caballero, F. & Del C Batlle, A.M. (1998) . Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice. European Journal of Cancer Prevention, 7(4), 337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010
---------- CHICAGO ----------
Gerez, E., Vazquez, E., Caballero, F., Del C Batlle, A.M. "Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice" . European Journal of Cancer Prevention 7, no. 4 (1998) : 337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010
---------- MLA ----------
Gerez, E., Vazquez, E., Caballero, F., Del C Batlle, A.M. "Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice" . European Journal of Cancer Prevention, vol. 7, no. 4, 1998, pp. 337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010
---------- VANCOUVER ----------
Gerez, E., Vazquez, E., Caballero, F., Del C Batlle, A.M. Beta-carotene partially prevents the damage induced by 1,4- dimethylaminoazobenzene in mice. Eur.J. Cancer Prev. 1998;7(4):337-342.
http://dx.doi.org/10.1097/00008469-199808000-00010