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antagonists and inhibitors

"Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction" (2018) Lunardi, P.;Sachser, R.M.;Sierra, R.O. (...)de Oliveira Alvares, L. Molecular Neurobiology. 55(2):958-967

"Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase" (2018) Kashif, M.;Chacón-Vargas, K.F.;López-Cedillo, J.C. (...)Rivera, G. European Journal of Medicinal Chemistry. 156:252-268

"Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors" (2018) Martínez, M.D.;Ghini, A.A.;Dansey, M.V. (...)Burton, G. Bioorganic and Medicinal Chemistry. 26(5):1092-1101

"Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations" (2018) Noguera, G.J.; Fabian, L.E.; Lombardo, E.; Finkielsztein, L.M. Organic and Biomolecular Chemistry. 16(44):8525-8536

"Calcium dynamics in tomato pollen tubes using the Yellow Cameleon 3.6 sensor" (2018) Barberini, M.L.;Sigaut, L.;Huang, W. (...)Muschietti, J. Plant Reproduction. 31(2):159-169

"A fluorescence nanoscopy marker for corticotropin-releasing hormone type 1 receptor: Computer design, synthesis, signaling effects, super-resolved fluorescence imaging, and: In situ affinity constant in cells" (2018) Szalai, A.M.;Armando, N.G.;Barabas, F.M. (...)Aramendía, P.F. Physical Chemistry Chemical Physics. 20(46):29212-29220

"In vivo hemin conditioning targets the vascular and immunologic compartments and restrains prostate tumor development" (2017) Jaworski, F.M.;Gentilini, L.D.;Gueron, G. (...)Vazquez, E.S. Clinical Cancer Research. 23(17):5135-5148

"Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats" (2017) Accialini, P.;Irusta, G.;Bechis, A. (...)Tesone, M. Molecular Reproduction and Development. 84(8):719-730

"Synergistic activity between statins and bisphosphonates against acute experimental toxoplasmosis" (2017) Li, Z.-H.;Li, C.;Szajnman, S.H. (...)Moreno, S.N.J. Antimicrobial Agents and Chemotherapy. 61(8)

"In Vitro and in Vivo activities of sulfur-containing linear bisphosphonates against apicomplexan parasites" (2017) Szajnman, S.H.;Galaka, T.;Li, Z.-H. (...)Rodriguez, J.B. Antimicrobial Agents and Chemotherapy. 61(2)

"Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer" (2017) Ramakrishnan, S.;Hu, Q.;Krishnan, N. (...)Woloszynska-Read, A. Cell Death and Disease. 8(12)

"Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity" (2017) Rodriguez, C.R.;Alvarez, L.D.;Dansey, M.V. (...)Burton, G. Journal of Steroid Biochemistry and Molecular Biology. 165:268-276

"The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients" (2017) Colado, A.;Almejún, M.B.;Podaza, E. (...)Borge, M. Cancer Immunology, Immunotherapy. 66(4):461-473

"Galectin-1-driven tolerogenic programs aggravate yersinia enterocolitica infection by repressing antibacterial immunity" (2017) Davicino, R.C.;Méndez-Huergo, S.P.;Eliçabe, R.J. (...)Rabinovich, G.A. Journal of Immunology. 199(4):1382-1392

"An in vitro and in vivo evaluation of new potential trans-sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method" (2017) Lara-Ramirez, E.E.;López-Cedillo, J.C.;Nogueda-Torres, B. (...)Rivera, G. European Journal of Medicinal Chemistry. 132:249-261

"Nitric oxide reduces paracellular resistance in rat thick ascending limbs by increasing Na+ and Cl- permeabilities" (2017) Monzon, C.M.; Occhipinti, R.; Pignataro, O.P.; Garvin, J.L. American Journal of Physiology - Renal Physiology. 312(6):F1035-F1043

"Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites" (2017) Galaka, T.;Casal, M.F.;Storey, M. (...)Rodriguez, J.B. Molecules. 22(1)

"Theoretical insights into the reaction and inhibition mechanism of metal-independent retaining glycosyltransferase responsible for mycothiol biosynthesis" (2017) Capurro, J.I.B.;Hopkins, C.W.;Sottile, G.P. (...)Marti, M.A. Journal of Physical Chemistry B. 121(3):471-478

"Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation" (2016) Krawczyk, M.C.;Navarro, N.;Blake, M.G. (...)Boccia, M.M. Neurobiology of Learning and Memory. 133:79-88

"Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex" (2016) González, B.;Rivero-Echeto, C.;Muñiz, J.A. (...)Bisagno, V. Addiction Biology. 21(3):589-602

"Synthesis of Enantiomeric Polyhydroxyalkylpyrrolidines from 1,3-Dipolar Cycloadducts. Evaluation as Inhibitors of a β-Galactofuranosidase" (2016) Oliveira Udry, G.A.; Repetto, E.; Vega, D.R.; Varela, O. Journal of Organic Chemistry. 81(10):4179-4189

"Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors" (2016) Michelini, F.M.;Bueno, C.A.;Molinari, A.M. (...)Ramírez, J.A. Biochimica et Biophysica Acta - General Subjects. 1860(1):129-139

"In vitro and in vivo studies of cholinesterases and carboxylesterases in Planorbarius corneus exposed to a phosphorodithioate insecticide: Finding the most sensitive combination of enzymes, substrates, tissues and recovery capacity" (2016) Otero, S.; Kristoff, G. Aquatic Toxicology. 180:186-195

"Hypothalamic POMC deficiency improves glucose tolerance despite insulin resistance by increasing Glycosuria" (2016) Chhabra, K.H.;Adams, J.M.;Fagel, B. (...)Low, M.J. Diabetes. 65(3):660-672

"Alternative Splicing of G9a Regulates Neuronal Differentiation" (2016) Fiszbein, A.;Giono, L.E.;Quaglino, A. (...)Kornblihtt, A.R. Cell Reports. 14(12):2797-2808

"Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)" (2016) Scotti, L.;Abramovich, D.;Pascuali, N. (...)Parborell, F. Reproduction, Fertility and Development. 28(6):690-699

"Editorial: Immunophilins, protein chemistry and cell biology of a promising new class of drug targets – Part I" (2016) Galigniana, M.D. Current Molecular Pharmacology. 9(1):3-4

"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase" (2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320

"Improvement of Chicken Primordial Germ Cell Maintenance In Vitro by Blockade of the Aryl Hydrocarbon Receptor Endogenous Activity" (2016) Pérez Sáez, J.M.; Bussmann, L.E.; Barañao, J.L.; Bussmann, U.A. Cellular Reprogramming. 18(3):154-161

"A bumpy road for RNA polymerase II" (2015) Giono, L.E.; Kornblihtt, A.R. Nature Structural and Molecular Biology. 22(5):353-355

"Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin" (2015) Chamorro, M.E.; Maltaneri, R.E.; Vittori, D.C.; Nesse, A.B. International Journal of Biochemistry and Cell Biology. 61:63-71

"Small molecules as anti-TNF drugs" (2015) Richmond, V.;Michelini, F.M.;Bueno, C.A. (...)Ramírez, J.A. Current Medicinal Chemistry. 22(25):2920-2942

"Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway" (2015) Bueno, C.A.;Michelini, F.M.;Pertino, M.W. (...)Alché, L.E. Medical Microbiology and Immunology. 204(5):575-584

"Exploring the molecular basis of action of ring D aromatic steroidal antiestrogens" (2015) Alvarez, L.D.; Veleiro, A.S.; Burton, G. Proteins: Structure, Function and Bioinformatics. 83(7):1297-1306

"Inhibition of platelet-derived growth factor (PDGF) receptor affects follicular development and ovarian proliferation, apoptosis and angiogenesis in prepubertal eCG-treated rats" (2015) Pascuali, N.;Scotti, L.;Abramovich, D. (...)Parborell, F. Molecular and Cellular Endocrinology. 412:148-158

"Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes" (2015) Gimenez, A.M.;Gesumaría, M.C.;Schoijet, A.C. (...)Machado, E.E. Molecular and Biochemical Parasitology. 203(1-2):14-24

"Destabilization of the torsioned conformation of a ligand side chain inverts the LXRβ activity" (2015) Álvarez, L.D.;Dansey, M.V.;Grinman, D.Y. (...)Burton, G. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851(12):1577-1586

"Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways" (2015) Barrientos, G.;Toro, A.;Moschansky, P. (...)Varone, C.L. Placenta. 36(4):419-426

"Immunophilins, protein chemistry and cell biology of a promising new class of drug targets – Part II" (2015) Galigniana, M.D. Current Molecular Pharmacology. 9(2):97-98

"Calcineurin phosphatase as a negative regulator of fear memory in hippocampus: Control on nuclear factor-κB signaling in consolidation and reconsolidation" (2014) de la Fuente, V.;Federman, N.;Fustiñana, M.S. (...)Romano, A. Hippocampus. 24(12):1549-1561

"Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells" (2014) Linero, F.N.;Fernández Bell-Fano, P.M.;Cuervo, E. (...)Scolaro, L.A. Archives of Virology. 160(2):469-475

"The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice" (2014) Meyer, M.;Gonzalez Deniselle, M.C.;Hunt, H. (...)De Nicola, A.F. Journal of Steroid Biochemistry and Molecular Biology. 143:40-48

"Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome" (2014) Scotti, L.;Abramovich, D.;Pascuali, N. (...)Parborell, F. Journal of Steroid Biochemistry and Molecular Biology. 144(PART B):392-401

"OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis" (2014) Astorgues-Xerri, L. European journal of cancer (Oxford, England : 1990). 50(14):2463-2477

"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines" (2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (...)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851

"In Vitro and in Vivo effects of tamoxifen against larval stage Echinococcus granulosus" (2014) Nicolao, M.C.;Elissondo, M.C.;Denegri, G.M. (...)Cumino, A.C. Antimicrobial Agents and Chemotherapy. 58(9):5146-5154

"Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice" (2014) Moiola, C.P.;Luca, P.D.;Zalazar, F. (...)De Siervi, A. Clinical Cancer Research. 20(15):4086-4095

"Quercetin antagonism of GABAAρ1 receptors is prevented by ascorbic acid through a redox-independent mechanism" (2013) Calero, C.I.;González, A.N.B.;Gasulla, J. (...)Calvo, D.J. European Journal of Pharmacology. 714(1-3):274-280

"Ca2+and Ca2+-activated K+ channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse" (2010) De San Martín, J.Z.; Pyott, S.; Ballestero, J.; Katz, E. Journal of Neuroscience. 30(36):12157-12167

"17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions" (2010) Gambino, Y.P.;Maymó, J.L.;Pérez-Pérez, A. (...)Varone, C.L. Biology of Reproduction. 83(1):42-51