Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Psychostimulant addiction is associated with dysfunctions in frontal cortex. Previous data demonstrated that repeated exposure to methamphetamine (METH) can alter prefrontal cortex (PFC)-dependent functions. Here, we show that withdrawal from repetitive non-contingent METH administration (7 days, 1 mg/kg) depressed voltage-dependent calcium currents (ICa) and increased hyperpolarization-activated cation current (IH) amplitude and the paired-pulse ratio of evoked excitatory postsynaptic currents (EPSCs) in deep-layer pyramidal mPFC neurons. Most of these effects were blocked by systemic co-administration of the D1/D5 receptor antagonist SCH23390 (0.5 and 0.05 mg/kg). In vitroMETH (i.e. bath-applied to slices from naïve-treated animals) was able to emulate its systemic effects on ICa and evoked EPSCs paired-pulse ratio. We also provide evidence of altered mRNA expression of (1) voltage-gated calcium channels P/Q-type Cacna1a (Cav2.1), N-type Cacna1b (Cav2.2), T-type Cav3.1 Cacna1g, Cav3.2 Cacna1h, Cav3.3 Cacna1i and the auxiliary subunit Cacna2d1 (α2δ1); (2) hyperpolarization-activated cyclic nucleotide-gated channels Hcn1 and Hcn2; and (3) glutamate receptors subunits AMPA-type Gria1, NMDA-type Grin1 and metabotropic Grm1 in the mouse mPFC after repeated METH treatment. Moreover, we show that some of these changes in mRNA expression were sensitive D1/5 receptor blockade. Altogether, these altered mechanisms affecting synaptic physiology and transcriptional regulation may underlie PFC functional alterations that could lead to PFC impairments observed in METH-addicted individuals. © 2015 Society for the Study of Addiction.

Registro:

Documento: Artículo
Título:Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex
Autor:González, B.; Rivero-Echeto, C.; Muñiz, J.A.; Cadet, J.L.; García-Rill, E.; Urbano, F.J.; Bisagno, V.
Filiación:Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Junín 956, piso 5, Buenos Aires, C1113, Argentina
Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias, Departamento de Fisiología, Biología Molecular y Celular 'Dr. Hector Maldonado' (DFBMC), Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States
Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Palabras clave:Dopamine receptors; glutamate; methamphetamine; prefrontal cortex; voltage-gated calcium channels; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; AMPA receptor; calcium channel N type; calcium channel P type; calcium channel Q type; calcium channel T type; cyclic nucleotide gated channel; dopamine 1 receptor; dopamine 5 receptor; messenger RNA; metabotropic receptor; methamphetamine; n methyl dextro aspartic acid receptor; AMPA receptor; benzazepine derivative; Cacna1b protein, mouse; Cacna1g protein, mouse; Cacna1h protein, mouse; Cacna1i protein, mouse; CACNA2D1 protein, mouse; calcium; calcium channel; calcium channel N type; calcium channel T type; dopamine 1 receptor; dopamine 5 receptor; dopamine uptake inhibitor; glutamate receptor ionotropic, AMPA 1; Gprin1 protein, mouse; Hcn1 protein, mouse; Hcn2 protein, mouse; hyperpolarization activated cyclic nucleotide gated channel; messenger RNA; methamphetamine; n methyl dextro aspartic acid receptor; nerve protein; potassium channel; voltage-dependent calcium channel (P-Q type); animal experiment; animal model; animal tissue; Article; Cacna1a gene; Cacna1b gene; Cacna1g gene; Cacna1h gene; Cacna1i gene; Cacna2d1 gene; calcium current; controlled study; excitatory postsynaptic potential; gene; gene expression; Gria1 gene; Grin1 gene; Hcn1 gene; Hcn2 gene; hyperpolarization; in vitro study; male; medial prefrontal cortex; methamphetamine dependence; mouse; nonhuman; priority journal; synaptic transmission; animal; antagonists and inhibitors; drug effects; genetics; metabolism; prefrontal cortex; pyramidal nerve cell; Animals; Benzazepines; Calcium; Calcium Channels; Calcium Channels, N-Type; Calcium Channels, T-Type; Dopamine Uptake Inhibitors; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Methamphetamine; Mice; Nerve Tissue Proteins; Potassium Channels; Prefrontal Cortex; Pyramidal Cells; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Synaptic Transmission
Año:2016
Volumen:21
Número:3
Página de inicio:589
Página de fin:602
DOI: http://dx.doi.org/10.1111/adb.12249
Título revista:Addiction Biology
Título revista abreviado:Addict. Biol.
ISSN:13556215
CODEN:ADBIF
CAS:8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate, 87134-87-0; methamphetamine, 28297-73-6, 51-57-0, 537-46-2, 7632-10-2; calcium, 7440-70-2, 14092-94-5; Benzazepines; Cacna1b protein, mouse; Cacna1g protein, mouse; Cacna1h protein, mouse; Cacna1i protein, mouse; CACNA2D1 protein, mouse; Calcium; Calcium Channels; Calcium Channels, N-Type; Calcium Channels, T-Type; Dopamine Uptake Inhibitors; glutamate receptor ionotropic, AMPA 1; Gprin1 protein, mouse; Hcn1 protein, mouse; Hcn2 protein, mouse; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Methamphetamine; Nerve Tissue Proteins; Potassium Channels; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D5; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; SCH 23390; voltage-dependent calcium channel (P-Q type)
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13556215_v21_n3_p589_Gonzalez

Referencias:

  • Ajima, A., Yamaguchi, T., Kato, T., Modulation of acetylcholine release by D1, D2 dopamine receptors in rat striatum under freely moving conditions (1990) Brain Res, 518, pp. 193-198
  • Arnsten, A.F., Prefrontal cortical network connections: Key site of vulnerability in stress and schizophrenia (2011) Int J Dev Neurosci, 29, pp. 215-223
  • Berger, T., Senn, W., Lüscher, H.R., Hyperpolarization-activated current Ih disconnects somatic and dendritic spike initiation zones in layer V pyramidal neurons (2003) J Neurophysiol, 90, pp. 2428-2437
  • Berridge, K.C., Robinson, T.E., What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience? (1998) Brain Res Brain Res Rev, 28, pp. 309-369
  • Bisagno, V., Raineri, M., Peskin, V., Wikinski, S.I., Uchitel, O.D., Llinás, R.R., Urbano, F.J., Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice (2010) Psychopharmacology (Berl), 212, pp. 205-214
  • Branco, T., Staras, K., The probability of neurotransmitter release: Variability and feedback control at single synapses (2009) Nat Rev Neurosci, 10, pp. 373-383
  • Cadet, J.L., Bisagno, V., Milroy, C.M., Neuropathology of substance use disorders (2014) Acta Neuropathol, 127, pp. 91-107
  • Cadet, J.L., Krasnova, I.N., Ladenheim, B., Cai, N.S., McCoy, M.T., Atianjoh, F.E., Methamphetamine preconditioning: Differential protective effects on monoaminergic systems in the rat brain (2009) Neurotox Res, 15, pp. 252-259
  • Cahill, E., Salery, M., Vanhoutte, P., Caboche, J., Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse (2014) Front Pharmacol, 4, pp. 1-13
  • Chen, B.T., Yau, H.J., Hatch, C., Kusumoto-Yoshida, I., Cho, S.L., Hopf, F.W., Bonci, A., Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking (2013) Nature, 496, pp. 359-362
  • Chu, H.Y., Zhen, X., Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems (2010) Acta Pharmacol Sin, 31, pp. 1036-1043
  • Cohen, S., Greenberg, M.E., Communication between the synapse and the nucleus in neuronal development, plasticity, and disease (2008) Annu Rev Cell Dev Biol, 24, pp. 183-209
  • Colecraft, H.M., Patil, P.G., Yue, D.T., Differential occurrence of reluctant openings in G-protein-inhibited N- and P/Q-type calcium channels (2000) J Gen Physiol, 115, pp. 175-192
  • Dolphin, A.C., Calcium channel auxiliary α2δ and β subunits: Trafficking and one step beyond (2012) Nat Rev Neurosci, 13, pp. 542-555
  • Ernst, T., Chang, L., Adaptation of brain glutamate plus glutamine during abstinence from chronic methamphetamine use (2008) J Neuroimmune Pharmacol, 3, pp. 165-172
  • Gao, C., Wolf, M.E., Dopamine receptors regulate NMDA receptor surface expression in prefrontal cortex neurons (2008) J Neurochem, 106, pp. 2489-2501
  • Gao, W.J., Krimer, L.S., Goldman-Rakic, P.S., Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits (2001) Proc Natl Acad Sci U S A, 98, pp. 295-300
  • Girault, J.A., Valjent, E., Caboche, J., Hervé, D., ERK2: A logical and gate critical for drug-induced plasticity? (2007) Curr Opin Pharmacol, 7, pp. 77-85
  • Goldman-Rakic, P.S., Muly, E.C., III, Williams, G.V., D(1) receptors in prefrontal cells and circuits (2000) Brain Res Brain Res Rev, 31, pp. 295-301
  • Goldstein, R.Z., Volkow, N.D., Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications (2011) Nat Rev Neurosci, 12, pp. 652-669
  • González, B., Raineri, M., Cadet, J.L., García-Rill, E., Urbano, F.J., Bisagno, V., Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice (2014) Neuropharmacology, 87, pp. 188-197
  • He, C., Chen, F., Li, B., Hu, Z., Neurophysiology of HCN channels: From cellular functions to multiple regulations (2014) Prog Neurobiol, 112, pp. 1-23
  • Huang, Z., Lujan, R., Kadurin, I., Uebele, V.N., Renger, J.J., Dolphin, A.C., Shah, M.M., Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses (2011) Nat Neurosci, 14, pp. 478-486
  • Jayanthi, S., McCoy, M.T., Chen, B., Britt, J.P., Kourrich, S., Yau, H.J., Ladenheim, B., Cadet, J.L., Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms (2014) Biol Psychiatry, 76, pp. 47-56
  • Kalivas, P.W., Cocaine and amphetamine-like psychostimulants: Neurocircuitry and glutamate neuroplasticity (2007) Dialogues Clin Neurosci, 9, pp. 389-397
  • Kamei, H., Nagai, T., Nakano, H., Togan, Y., Takayanagi, M., Takahashi, K., Kobayashi, K., Yamada, K., Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice (2006) Biol Psychiatry, 59, pp. 75-84
  • Kauer, J.A., Malenka, R.C., Synaptic plasticity and addiction (2007) Nat Rev Neurosci, 8, pp. 844-858
  • Kawamoto, E.M., Vivar, C., Camandola, S., Physiology and pathology of calcium signaling in the brain (2012) Front Pharmacol, 3, pp. 1-17
  • Kisilevsky, A.E., Mulligan, S.J., Altier, C., Iftinca, M.C., Varela, D., Tai, C., Chen, L., Zamponi, G.W., D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry (2008) Neuron, 58, pp. 557-570
  • Kurokawa, K., Shibasaki, M., Ohkuma, S., Methamphetamine-induced up-regulation of α2/δ subunit of voltage-gated calcium channels is regulated by da receptors (2010) Synapse, 64, pp. 822-828
  • Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., Nusser, Z., Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites (2002) Nat Neurosci, 5, pp. 1185-1193
  • Lu, H., Zou, Q., Chefer, S., Ross, T.J., Vaupel, D.B., Guillem, K., Rea, W., Stein, E.A., Abstinence from cocaine and sucrose self-administration reveals altered mesocorticolimbic circuit connectivity (2014) Brain Connect, 4, pp. 499-510
  • Lüthi, A., McCormick, D.A., Periodicity of thalamic synchronized oscillations: The role of Ca2+-mediated upregulation of Ih (1998) Neuron, 20, pp. 553-563
  • Magee, J.C., Dendritic lh normalizes temporal summation in hippocampal CA1 neurons (1999) Nat Neurosci, 2, pp. 508-514
  • Mair, R.D., Kauer, J.A., Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses (2007) Neuropharmacology, 52, pp. 193-199
  • Martin, T.A., Jayanthi, S., McCoy, M.T., Brannock, C., Ladenheim, B., Garrett, T., Lehrmann, E., Cadet, J.L., Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens (2012) PLoS ONE, 7, p. e34236
  • (2003) Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research. Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research, , National research Council of the National Academies. Washington, DC: The National Academies Press
  • Nolan, M.F., Malleret, G., Dudman, J.T., Buhl, D.L., Santoro, B., Gibbs, E., Vronskaya, S., Morozov, A., A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons (2004) Cell, 119, pp. 719-732
  • Parsegian, A., See, R.E., Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats (2014) Neuropsychopharmacology, 39, pp. 811-822
  • Rinaldi, A., Mandillo, S., Oliverio, A., Mele, A., D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice (2007) Neuropsychopharmacology, 32, pp. 309-319
  • Rosenkranz, J.A., Johnston, D., Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex (2006) J Neurosci, 26, pp. 3229-3244
  • Santoro, B., Chen, S., Luthi, A., Pavlidis, P., Shumyatsky, G.P., Tibbs, G.R., Siegelbaum, S.A., Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS (2000) J Neurosci, 20, pp. 5264-5275
  • Santos-Vera, B., Vázquez-Torres, R., Marrero, H.G., Acevedo, J.M., Arencibia-Albite, F., Vélez-Hernández, M.E., Miranda, J.D., Jiménez-Rivera, C.A., Cocaine sensitization increases I h current channel subunit 2 (HCN2) protein expression in structures of the mesocorticolimbic system (2013) J Mol Neurosci, 50, pp. 234-245
  • Seamans, J.K., Durstewitz, D., Christie, B.R., Stevens, C.F., Sejnowski, T.J., Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons (2001) Proc Natl Acad Sci U S A, 98, pp. 301-306
  • Starr, B.S., Starr, M.S., Differential effects of dopamine D1 and D2 agonists and antagonists on velocity of movement, rearing and grooming in the mouse. Implications for the roles of D1 and D2 receptors (1986) Neuropharmacology, 25, pp. 455-463
  • Sun, X., Zhao, Y., Wolf, M.E., Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons (2005) J Neurosci, 25, pp. 7342-7351
  • Surmeier, D.J., Bargas, J., Hemmings, H.C., Jr., Nairn, A.C., Greengard, P., Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons (1995) Neuron, 14, pp. 385-397
  • Talley, E.M., Cribbs, L.L., Lee, J.H., Daud, A., Perez-Reyes, E., Bayliss, D.A., Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels (1999) J Neurosci, 19, pp. 1895-1911
  • Tritsch, N.X., Sabatini, B.L., Dopaminergic modulation of synaptic transmission in cortex and striatum (2012) Neuron, 76, pp. 33-50
  • Urbano, F.J., Bisagno, V., Wikinski, S.I., Uchitel, O.D., Llinás, R.R., Cocaine acute 'binge' administration results in altered thalamocortical interactions in mice (2009) Biol Psychiatry, 66, pp. 769-776
  • Wachtel, S.R., Brooderson, R.J., White, F.J., Parametric and pharmacological analyses of the enhanced grooming response elicited by the D1 dopamine receptor agonist SKF 38393 in the rat (1992) Psychopharmacology (Berl), 109, pp. 41-48
  • Wachtel, S.R., White, F.J., The dopamine D1 receptor antagonist SCH 23390 can exert D1 agonist-like effects on rat nucleus accumbens neurons (1995) Neurosci Lett, 199, pp. 13-16
  • Wang, M., Ramos, B.P., Paspalas, C.D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Arnsten, A.F., Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex (2007) Cell, 129, pp. 397-410
  • Wu, J., Hablitz, J.J., Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons (2005) J Neurosci, 25, pp. 6322-6328
  • Young, C.E., Yang, C.R., Dopamine D1/D5 receptor modulates state-dependent switching of soma-dendritic Ca2+ potentials via differential protein kinase A and C activation in rat prefrontal cortical neurons (2004) J Neurosci, 24, pp. 8-23
  • Zucker, R.S., Regehr, W.G., Short-term synaptic plasticity (2002) Annu Rev Physiol, 64, pp. 355-405

Citas:

---------- APA ----------
González, B., Rivero-Echeto, C., Muñiz, J.A., Cadet, J.L., García-Rill, E., Urbano, F.J. & Bisagno, V. (2016) . Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex. Addiction Biology, 21(3), 589-602.
http://dx.doi.org/10.1111/adb.12249
---------- CHICAGO ----------
González, B., Rivero-Echeto, C., Muñiz, J.A., Cadet, J.L., García-Rill, E., Urbano, F.J., et al. "Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex" . Addiction Biology 21, no. 3 (2016) : 589-602.
http://dx.doi.org/10.1111/adb.12249
---------- MLA ----------
González, B., Rivero-Echeto, C., Muñiz, J.A., Cadet, J.L., García-Rill, E., Urbano, F.J., et al. "Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex" . Addiction Biology, vol. 21, no. 3, 2016, pp. 589-602.
http://dx.doi.org/10.1111/adb.12249
---------- VANCOUVER ----------
González, B., Rivero-Echeto, C., Muñiz, J.A., Cadet, J.L., García-Rill, E., Urbano, F.J., et al. Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex. Addict. Biol. 2016;21(3):589-602.
http://dx.doi.org/10.1111/adb.12249