The identification of a second regulatory checkpoint controlling RNA polymerase II elongation near the poly(A) site of protein-coding genes reveals an additional level of complexity in the modulation of eukaryotic transcriptional elongation and termination. © 2015 Nature America, Inc. All rights reserved.
Documento: | Artículo |
Título: | A bumpy road for RNA polymerase II |
Autor: | Giono, L.E.; Kornblihtt, A.R. |
Filiación: | Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
Palabras clave: | cyclin dependent kinase 9; histone; messenger RNA precursor; polyadenylic acid; RNA polymerase II; cyclin dependent kinase 9; glyceraldehyde 3 phosphate dehydrogenase; Article; chromatin structure; enzyme activity; enzyme inhibition; eukaryote; histone modification; nucleosome; polyadenylation; priority journal; promoter region; protein cleavage; protein DNA interaction; protein function; RNA processing; signal transduction; transcription elongation; transcription initiation site; transcription regulation; transcription termination; antagonists and inhibitors; biosynthesis; drug effects; genetic transcription; human; RNA translation; Eukaryota; Cyclin-Dependent Kinase 9; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Humans; Peptide Chain Elongation, Translational; Transcription, Genetic |
Año: | 2015 |
Volumen: | 22 |
Número: | 5 |
Página de inicio: | 353 |
Página de fin: | 355 |
DOI: | http://dx.doi.org/10.1038/nsmb.3020 |
Título revista: | Nature Structural and Molecular Biology |
Título revista abreviado: | Nat. Struct. Mol. Biol. |
ISSN: | 15459993 |
CODEN: | NSMBC |
CAS: | histone, 9062-68-4; polyadenylic acid, 24937-83-5; glyceraldehyde 3 phosphate dehydrogenase, 9001-50-7; Cyclin-Dependent Kinase 9; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15459993_v22_n5_p353_Giono |