Artículo

Scotti, L.; Abramovich, D.; Pascuali, N.; Durand, L.H.; Irusta, G.; De Zúñiga, I.; Tesone, M.; Parborell, F. "Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)" (2016) Reproduction, Fertility and Development. 28(6):690-699
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Ovarian hyperstimulation syndrome (OHSS) is a complication of ovarian stimulation with gonadotrophins following human chorionic gonadotrophin (hCG) administration. The relationship between hCG and OHSS is partly mediated via the production of angiogenic factors, such as vascular endothelial growth factor A (VEGFA) and angiopoietins (ANGPTs). Here, we investigated the effect of ANGPT1 inhibition on ovarian angiogenesis in follicular fluid (FF) from women at risk of OHSS, using the chorioallantoic membrane (CAM) of quail embryos as an experimental model. We also analysed cytoskeletal changes and endothelial junction protein expression induced by this FF in the presence or absence of an ANGPT1-neutralising antibody in endothelial cell cultures. The presence of this antibody restored the number of vascular branch points and integrin αvβ3 levels in the CAMs to control values. ANGPT1 inhibition in FF from OHSS patients also restored the levels of claudin-5, vascular endothelial cadherin and phosphorylated β-catenin and partially reversed actin redistribution in endothelial cells. Our findings suggest that ANGPT1 increases pathophysiological angiogenesis in patients at risk of OHSS by acting on tight and adherens junction proteins. Elucidating the mechanisms by which ANGPT1 regulates vascular development and cell-cell junctions in OHSS will contribute to identifying new therapeutic targets for the treatment of human diseases with aberrant vascular leakage. © CSIRO 2016.

Registro:

Documento: Artículo
Título:Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)
Autor:Scotti, L.; Abramovich, D.; Pascuali, N.; Durand, L.H.; Irusta, G.; De Zúñiga, I.; Tesone, M.; Parborell, F.
Filiación:Instituto de Biología y Medicina Experimental (IByME) - CONICET, Vuelta de Obligado, Buenos Aires, 2490 (1428), Argentina
Centro Médico PREGNA Medicina Reproductiva, Juncal Buenos Aires, 3490 (1425), Argentina
Departamento de Química Bioló Gica, Facultad de Ciencias Exactas y Naturales - Universidad de Buenos Aires, Intendente Güiraldes, Buenos Aires, 2160 (1428), Argentina
Palabras clave:angiogenesis; follicular fluid; ovary; reproduction.; actin; adherens junction protein; angiopoietin 1; beta catenin; claudin 5; neutralizing antibody; protein ZO1; tight junction protein; unclassified drug; vascular endothelial cadherin; vitronectin receptor; angiopoietin 1; ANGPT1 protein, human; biological marker; monoclonal antibody; neutralizing antibody; adult; animal cell; animal experiment; antiangiogenic activity; Article; cell culture; cellular distribution; chorioallantois; controlled study; Coturnix japonica; cytoskeleton; embryo; endothelium cell; experimental model; human; human cell; human tissue; in vivo study; nonhuman; ovary follicle fluid; ovary hyperstimulation; protein expression; adherens junction; animal; antagonists and inhibitors; Argentina; bioassay; cell line; Coturnix; cytology; drug effects; female; metabolism; Neovascularization, Pathologic; Ovarian Hyperstimulation Syndrome; ovary follicle; ovary follicle fluid; pathology; pathophysiology; risk; tight junction; vascular endothelium; vascularization; Adherens Junctions; Adult; Angiopoietin-1; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Argentina; Biological Assay; Biomarkers; Cell Line; Cells, Cultured; Chorioallantoic Membrane; Coturnix; Endothelium, Vascular; Female; Follicular Fluid; Humans; Neovascularization, Pathologic; Ovarian Follicle; Ovarian Hyperstimulation Syndrome; Risk; Tight Junctions
Año:2016
Volumen:28
Número:6
Página de inicio:690
Página de fin:699
DOI: http://dx.doi.org/10.1071/RD13356
Título revista:Reproduction, Fertility and Development
Título revista abreviado:Reprod. Fertil. Dev.
ISSN:10313613
CODEN:RFDEE
CAS:angiopoietin 1, 186270-49-5; Angiopoietin-1; ANGPT1 protein, human; Antibodies, Monoclonal; Antibodies, Neutralizing; Biomarkers
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10313613_v28_n6_p690_Scotti

Referencias:

  • Abramovich, D., Parborell, F., Tesone, M., Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotrophin-treated prepubertal rats (2006) Biol. Reprod, 75, pp. 434-441
  • Artini, P.G., Monti, M., Fasciani, A., Tartaglia, M.L., D'Ambrogio, G., Genazzani, A.R., Correlation between the amount of folliclestimulating hormone administered and plasma and follicular fluid vascular endothelial growth factor concentrations in women undergoing in vitro fertilisation (1998) Gynecol. Endocrinol, 12, pp. 243-247
  • Avraamides, C.J., Garmy-Susini, B., Varner, J.A., Integrins in angiogenesis and lymphangiogenesis (2008) Nat. Rev. Cancer, 8, pp. 604-617
  • Bai, Y., Cui, M., Meng, Z., Shen, L., He, Q., Zhang, X., Chen, F., Xiao, J., Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway (2009) Biochem. Biophys. Res. Commun, 378, pp. 296-301
  • Berube, M., Deschambeault, A., Boucher, M., Germain, L., Petitclerc, E., Guerin, S.L., MMP-2 expression in uveal melanoma: Differential activation status dictated by the cellular environment (2005) Mol. Vis, 11, pp. 1101-1111
  • Bienz, M., Clevers, H., Linking colorectal cancer to Wnt signalling (2000) Cell, 103, pp. 311-320
  • Brooks, P.C., Clark, R.A., Cheresh, D.A., Requirement of vascular integrin alpha v beta 3 for angiogenesis (1994) Science, 264, pp. 569-571
  • Brooks, P.C., Silletti, S., Von Schalscha, T.L., Friedlander, M., Cheresh, D.A., Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin-binding activity (1998) Cell, 92, pp. 391-400
  • Carmeliet, P., Fibroblast growth factor-1 stimulates branching and survival of myocardial arteries: A goal for therapeutic angiogenesis? (2000) Circ Res, 87, pp. 176-178
  • Carmeliet, P., Lampugnani, M.G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Dejana, E., Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis (1999) Cell, 98, pp. 147-157
  • Chen, S.U., Chou, C.H., Lin, C.W., Lee, H., Wu, J.C., Lu, H.F., Chen, C.D., Yang, Y.S., Signal mechanisms of vascular endothelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: Dopamine targets their common pathways (2010) Hum. Reprod, 25, pp. 757-767
  • Davis, S., Aldrich, T.H., Jones, P.F., Acheson, A., Compton, D.L., Jain, V., Ryan, T.E., Yancopoulos, G.D., Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning (1996) Cell, 87, pp. 1161-1169
  • Dejana, E., Tournier-Lasserve, E., Weinstein, B.M., The control of vascular integrity by endothelial cell junctions: Molecular basis and pathological implications (2009) Dev. Cell, 16, pp. 209-221
  • Edgell, C.J., McDonald, C.C., Graham, J.B., Permanent cell line expressing human factor VIII-related antigen established by hybridisation (1983) Proc. Natl. Acad. Sci. USA, 80, pp. 3734-3737
  • Edgell, C.J., Haizlip, J.E., Bagnell, C.R., Packenham, J.P., Harrison, P., Wilbourn, B., Madden, V.J., Endothelium specific Weibel-Palade bodies in a continuous human cell line, EA.hy926 (1990) Vitro Cell. Dev. Biol, 26, pp. 1167-1172
  • Eliceiri, B.P., Klemke, R., Stromblad, S., Cheresh, D.A., Integrin alpha v beta 3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis (1998) J. Cell Biol, 140, pp. 1255-1263
  • Enskog, A., Henriksson, M., Unander, M., Nilsson, L., Brannstrom, M., Prospective study of the clinical and laboratory parameters of patients in whom ovarian hyperstimulation syndrome developed during controlled ovarian hyperstimulation for in vitro fertilisation (1999) Fertil. Steril, 71, pp. 808-814
  • Fiedler, U., Augustin, H.G., Angiopoietins: A link between angiogenesis and inflammation (2006) Trends Immunol, 27, pp. 552-558
  • Gavard, J., Gutkind, J.S., VE-cadherin and claudin-5: It takes two to tango (2008) Nat. Cell Biol, 10, pp. 883-885
  • Goede, V., Schmidt, T., Kimmina, S., Kozian, D., Augustin, H.G., Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis (1998) Lab. Invest, 78, pp. 1385-1394
  • Gomez, R., Soares, S.R., Busso, C., Garcia-Velasco, J.A., Simon, C., Pellicer, A., Physiology and pathology of ovarian hyperstimulation syndrome (2010) Semin. Reprod. Med, 28, pp. 448-457
  • Groten, T., Fraser, H.M., Duncan, W.C., Konrad, R., Kreienberg, R., Wulff, C., Cell junctional proteins in the human corpus luteum: Changes during the normal cycle and after hCG treatment (2006) Hum. Reprod, 21, pp. 3096-3102
  • Hanahan, D., Folkman, J., Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis (1996) Cell, 86, pp. 353-364
  • Hartsock, A., Nelson, W.J., Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton (2008) Biochim. Biophys. Acta, 1778, pp. 660-669
  • Hazzard, T.M., Molskness, T.A., Chaffin, C.L., Stouffer, R.L., Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval (1999) Mol. Hum. Reprod, 5, pp. 1115-1121
  • Herr, D., Fraser, H.M., Konrad, R., Holzheu, I., Kreienberg, R., Wulff, C., Human chorionic gonadotrophin controls luteal vascular permeability via vascular endothelial growth factor by down-regulation of a cascade of adhesion proteins (2013) Fertil. Steril, 99, pp. 1749-1758
  • Hino, S., Tanji, C., Nakayama, K.I., Kikuchi, A., Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilises beta-catenin through inhibition of its ubiquitination (2005) Mol. Cell. Biol, 25, pp. 9063-9072
  • Humaidan, P., Quartarolo, J., Papanikolaou, E.G., Preventing ovarian hyperstimulation syndrome: Guidance for the clinician (2010) Fertil. Steril, 94, pp. 389-400
  • Isachenko, V., Mallmann, P., Petrunkina, A.M., Rahimi, G., Nawroth, F., Hancke, K., Felberbaum, R., Isachenko, E., Comparison of in vitro and chorioallantoic membrane (CAM) culture systems for cryopreserved medulla-contained human ovarian tissue (2012) PLoS ONE, 7, p. e32549
  • Itoh, M., Nagafuchi, A., Moroi, S., Tsukita, S., Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments (1997) J. Cell Biol, 138, pp. 181-192
  • Jiao, H., Wang, Z., Liu, Y., Wang, P., Xue, Y., Specific role of tight junction proteins claudin-5, occludin and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult (2011) J. Mol. Neurosci, 44, pp. 130-139
  • Kanda, T., Numata, Y., Mizusawa, H., Chronic inflammatory demyelinating polyneuropathy: Decreased claudin-5 and relocated ZO-1 (2004) J. Neurol. Neurosurg. Psychiatry, 75, pp. 765-769
  • Kitajima, Y., Endo, T., Nagasawa, K., Manase, K., Honnma, H., Baba, T., Hayashi, T., Saito, H., Hyperstimulation and a gonadotrophin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5 (2006) Endocrinology, 147 (2), pp. 694-699
  • Koos, R.D., Increased expression of vascular endothelial growth/ permeability factor in the rat ovary following an ovulatory gonadotrophin stimulus: Potential roles in follicle rupture (1995) Biol. Reprod, 52, pp. 1426-1435
  • Krasnow, J.S., Berga, S.L., Guzick, D.S., Zeleznik, A.J., Yeo, K.T., Vascular permeability factor and vascular endothelial growth factor in ovarian hyperstimulation syndrome: A preliminary report (1996) Fertil. Steril, 65, pp. 552-555
  • Kunzi-Rapp, K., Ruck, A., Kaufmann, R., Characterisation of the chick chorioallantoic membrane model as a short-term in vivo system for human skin (1999) Arch. Dermatol. Res, 291, pp. 290-295
  • Lampugnani, M.G., Endothelial cell-to-cell junctions: Adhesion and signalling in physiology and pathology (2012) Cold Spring Harb. Perspect. Med, 2, p. a006528
  • Lauffenburger, D.A., Horwitz, A.F., Cell migration: A physically integrated molecular process (1996) Cell, 84, pp. 359-369
  • Leng, T., Miller, J.M., Bilbao, K.V., Palanker, D.V., Huie, P., Blumenkranz, M.S., The chick chorioallantoic membrane as a model tissue for surgical retinal research and simulation (2004) Retina, 24, pp. 427-434
  • Leung, P., Ho, Y.B., Moon, Y.S., Effect of prolactin in an experimental model of the ovarian hyperstimulation syndrome (1983) Am. J. Obstet. Gynecol, 145, pp. 847-849
  • Levin, E.R., Rosen, G.F., Cassidenti, D.L., Yee, B., Meldrum, D., Wisot, A., Pedram, A., Role of vascular endothelial cell growth factor in ovarian hyperstimulation syndrome (1998) J. Clin. Invest, 102, pp. 1978-1985
  • Maisonpierre, P.C., Suri, C., Jones, P.F., Bartunkova, S., Wiegand, S.J., Radziejewski, C., Compton, D., Yancopoulos, G.D., Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis (1997) Science, 277, pp. 55-60
  • Malik, A.B., Lynch, J.J., Cooper, J.A., Endothelial barrier function (1989) J. Invest. Dermatol, 93, pp. 62S-67S
  • Maruo, N., Morita, I., Shirao, M., Murota, S., IL-6 increases endothelial permeability in vitro (1992) Endocrinology, 131, pp. 710-714
  • Menager, C., Vassy, J., Doliger, C., Legrand, Y., Karniguian, A., Subcellular localization of RhoA and ezrin at membrane ruffles of human endothelial cells: Differential role of collagen and fibronectin (1999) Exp. Cell Res, 249, pp. 221-230
  • Nap, A.W., Dunselman, G.A., DeGoeij, A.F., Evers, J.L., AndGroothuis, P.G., Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model (2004) Hum. Reprod, 19, pp. 2180-2187
  • Navot, D., Margalioth, E.J., Laufer, N., Birkenfeld, A., Relou, A., Rosler, A., Schenker, J.G., Direct correlation between plasma renin activity and severity of the ovarian hyperstimulation syndrome (1987) Fertil. Steril, 48, pp. 57-61
  • Navot, D., Bergh, P.A., Laufer, N., Ovarian hyperstimulation syndrome in novel reproductive technologies: Prevention and treatment (1992) Fertil. Steril, 58, pp. 249-261
  • Neufeld, G., Cohen, T., Gengrinovitch, S., Poltorak, Z., Vascular endothelial growth factor (VEGF) and its receptors (1999) FASEB J, 13, pp. 9-22
  • Orvieto, R., Ovarian hyperstimulation syndrome-An optimal solution for an unresolved enigma (2013) J. Ovarian. Res, 6, p. 77
  • Otrock, Z.K., Mahfouz, R.A., Makarem, J.A., Shamseddine, A.I., Understanding the biology of angiogenesis: Review of the most important molecular mechanisms (2007) Blood Cells Mol. Dis, 39, pp. 212-220
  • Parborell, F., Abramovich, D., Tesone, M., Intrabursal administration of the anti-angiopoietin 1 antibody produces a delay in rat follicular development associated with an increase in ovarian apoptosis mediated by changes in the expression of BCL2-related genes (2008) Biol. Reprod, 78, pp. 506-513
  • Parsons-Wingerter, P., Lwai, B., Yang, M.C., Elliott, K.E., Milaninia, A., Redlitz, A., Clark, J.I., Sage, E.H., A novel assay of angiogenesis in the quail chorioallantoic membrane: Stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection (1998) Microvasc. Res, 55, pp. 201-214
  • Phillips, H.S., Hains, J., Leung, D.W., Ferrara, N., Vascular endothelial growth factor is expressed in rat corpus luteum (1990) Endocrinology, 127, pp. 965-967
  • Pride, S.M., Ho, Y.B., Moon, Y.S., Clinical, endocrinologic and intraovarian prostaglandin F responses to H-1 receptor blockade in the ovarian hyperstimulation syndrome: Studies in the rabbit model (1984) Am. J. Obstet. Gynecol, 148, pp. 670-674
  • Rodewald, M., Herr, D., Fraser, H.M., Hack, G., Kreienberg, R., Wulff, C., Regulation of tight junction proteins occludin and claudin 5 in the primate ovary during the ovulatory cycle and after inhibition of vascular endothelial growth factor (2007) Mol. Hum. Reprod, 13, pp. 781-789
  • Rodewald, M., Herr, D., Duncan, W.C., Fraser, H.M., Hack, G., Konrad, R., Gagsteiger, F., Wulff, C., Molecular mechanisms of ovarian hyperstimulation syndrome: Paracrine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability (2009) Hum. Reprod, 24, pp. 1191-1199
  • Schenker, J.G., Polishuk, W.Z., The role of prostaglandins in ovarian hyperstimulation syndrome (1976) Eur. J. Obstet. Gynecol. Reprod. Biol, 6, pp. 47-52
  • Scotti, L., Abramovich, D., Pascuali, N., De Zuniga, I., Oubina, A., Kopcow, L., Lange, S., Parborell, F., Involvement of the ANGPTs/Tie-2 systemin ovarian hyperstimulation syndrome (OHSS) (2013) Mol. Cell. Endocrinol, 365, pp. 223-230
  • Suri, C., Jones, P.F., Patan, S., Bartunkova, S., Maisonpierre, P.C., Davis, S., Sato, T.N., Yancopoulos, G.D., Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis (1996) Cell, 87, pp. 1171-1180
  • Taddei, A., Giampietro, C., Conti, A., Orsenigo, F., Breviario, F., Pirazzoli, V., Potente, M., Dejana, E., Endothelial adherens junctions control tight junctions by VE-cadherinmediated upregulation of claudin-5 (2008) Nat. Cell Biol, 10, pp. 923-934
  • Umeda, K., Ikenouchi, J., Katahira-Tayama, S., Furuse, K., Sasaki, H., Nakayama, M., Matsui, T., Tsukita, S., ZO-1 and ZO-2 independently determine where claudins are polymerised in tight-junction strand formation (2006) Cell, 126, pp. 741-754
  • Valdes, T.I., Kreutzer, D., Moussy, F., The chick chorioallantoic membrane as a novel in vivo model for the testing of biomaterials (2002) J. Biomed. Mater. Res, 62, pp. 273-282
  • Villasante, A., Pacheco, A., Ruiz, A., Pellicer, A., Garcia-Velasco, J.A., Vascular endothelial cadherin regulates vascular permeability: Implications for ovarian hyperstimulation syndrome (2007) J. Clin. Endocrinol. Metab, 92, pp. 314-321
  • Von Otte, S., Paletta, J.R., Becker, S., Konig, S., Fobker, M., Greb, R.R., Kiesel, L., Nofer, J.R., Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis (2006) J. Biol. Chem, 281, pp. 5398-5405
  • Wojciak-Stothard, B., Potempa, S., Eichholtz, T., Ridley, A.J., Rho and Rac but not Cdc42 regulate endothelial cell permeability (2001) J. Cell Sci, 114, pp. 1343-1355
  • Zaidise, I., Friedman, M., Lindenbaum, E.S., Askenazi, R., Peretz, B.A., Paldi, E., Serotonin and the ovarian hyperstimulation syndrome (1983) Eur. J. Obstet. Gynecol. Reprod. Biol, 15, pp. 55-60
  • Zehendner, C.M., Librizzi, L., De Curtis, M., Kuhlmann, C.R., Luhmann, H.J., Caspase-3 contributes to ZO-1 and Cl-5 tightjunction disruption in rapid anoxic neurovascular unit damage (2011) PLoS ONE, 6, p. e16760

Citas:

---------- APA ----------
Scotti, L., Abramovich, D., Pascuali, N., Durand, L.H., Irusta, G., De Zúñiga, I., Tesone, M.,..., Parborell, F. (2016) . Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS). Reproduction, Fertility and Development, 28(6), 690-699.
http://dx.doi.org/10.1071/RD13356
---------- CHICAGO ----------
Scotti, L., Abramovich, D., Pascuali, N., Durand, L.H., Irusta, G., De Zúñiga, I., et al. "Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)" . Reproduction, Fertility and Development 28, no. 6 (2016) : 690-699.
http://dx.doi.org/10.1071/RD13356
---------- MLA ----------
Scotti, L., Abramovich, D., Pascuali, N., Durand, L.H., Irusta, G., De Zúñiga, I., et al. "Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS)" . Reproduction, Fertility and Development, vol. 28, no. 6, 2016, pp. 690-699.
http://dx.doi.org/10.1071/RD13356
---------- VANCOUVER ----------
Scotti, L., Abramovich, D., Pascuali, N., Durand, L.H., Irusta, G., De Zúñiga, I., et al. Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS). Reprod. Fertil. Dev. 2016;28(6):690-699.
http://dx.doi.org/10.1071/RD13356