Accialini, P.; Irusta, G.; Bechis, A.; Bas, D.; Parborell, F.; Abramovich, D.; Tesone, M. "Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats" (2017) Molecular Reproduction and Development. 84(8):719-730
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Tankyrases are physiological regulators of Axin, a protein involved in several cellular processes, including Wnt signaling. Here, we investigated the effect of a specific Tankyrase inhibitor (XAV939) in follicular-luteal dynamics, and its possible relationship with ovarian vascular development. Studies were designed to analyze the effect of intrabursa administration of XAV939 in gonadotropin-treated prepubertal rats. In particular, we examined follicle and corpus luteum development, steroidogenesis, angiogenic markers, and apoptotic parameters. We found that in vivo inhibition of Wnt signaling impaired corpus luteum development, with a decrease in the number of corpora lutea balanced by a high number of cysts; decreased circulating progesterone levels, likely due to a decrease in Steroidogenic acute regulatory protein content in the corpus luteum; and increased pro-apoptotic parameters. In addition, Extracellular signal-regulated kinase phosphorylation, Vascular endothelium growth factor 120 content, and endothelial cell area were diminished in corpora lutea of inhibitor-treated ovaries. Thus, Wnt/β-catenin signaling appears to participate in the regulation of corpus luteum development and luteal cell function. © 2017 Wiley Periodicals, Inc.


Documento: Artículo
Título:Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats
Autor:Accialini, P.; Irusta, G.; Bechis, A.; Bas, D.; Parborell, F.; Abramovich, D.; Tesone, M.
Filiación:Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
Departamento de Quıímica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:luteinization; progesterone; steroidogenesis; Tankyrase inhibitor; Wnt/β-catenin; 7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol; beta catenin; gonadotropin; mitogen activated protein kinase; progesterone; protein kinase B; steroidogenic acute regulatory protein; tankyrase; vasculotropin; Wnt protein; beta catenin; gonadotropin; progesterone; tankyrase; Wnt protein; angiogenesis; animal experiment; animal tissue; antral follicle; apoptosis; Article; cell proliferation; controlled study; corpus luteum; enzyme inhibition; enzyme phosphorylation; female; in vivo study; luteal cell; nonhuman; ovary follicle development; priority journal; progesterone blood level; rat; steroidogenesis; Wnt signaling pathway; animal; antagonists and inhibitors; corpus luteum; metabolism; physiology; signal transduction; Animals; beta Catenin; Corpus Luteum; Female; Gonadotropins; Progesterone; Rats; Signal Transduction; Tankyrases; Wnt Proteins
Página de inicio:719
Página de fin:730
Título revista:Molecular Reproduction and Development
Título revista abreviado:Mol. Reprod. Dev.
CAS:7,8 dihydro 2 [4 (trifluoromethyl)phenyl] 5h thiopyrano[4,3 d]pyrimidin 4 ol, 284028-89-3; gonadotropin, 63231-54-9; mitogen activated protein kinase, 142243-02-5; progesterone, 57-83-0; protein kinase B, 148640-14-6; steroidogenic acute regulatory protein, 168183-61-7; tankyrase, 9055-67-8; vasculotropin, 127464-60-2; beta Catenin; Gonadotropins; Progesterone; Tankyrases; Wnt Proteins


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---------- APA ----------
Accialini, P., Irusta, G., Bechis, A., Bas, D., Parborell, F., Abramovich, D. & Tesone, M. (2017) . Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats. Molecular Reproduction and Development, 84(8), 719-730.
---------- CHICAGO ----------
Accialini, P., Irusta, G., Bechis, A., Bas, D., Parborell, F., Abramovich, D., et al. "Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats" . Molecular Reproduction and Development 84, no. 8 (2017) : 719-730.
---------- MLA ----------
Accialini, P., Irusta, G., Bechis, A., Bas, D., Parborell, F., Abramovich, D., et al. "Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats" . Molecular Reproduction and Development, vol. 84, no. 8, 2017, pp. 719-730.
---------- VANCOUVER ----------
Accialini, P., Irusta, G., Bechis, A., Bas, D., Parborell, F., Abramovich, D., et al. Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats. Mol. Reprod. Dev. 2017;84(8):719-730.