Abstract:
Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with heterogeneity in the percentage of positive cells within the tumor mass. Tumors presented an important infiltration of macrophages, particularly associated to areas of active angiogenesis. Microvascular development, assessed by immunohistochemistry, correlated with the high percentage of cells expressing MCP-1/CCL-2. There was also significant correlation with vascularization and mitotic index. These results suggest that vascularization could be predictive of more aggressive melanoma metastasis, where the MCP-1/CCL-2 expression would be closely associated to vessel development through macrophages recruitment.
Registro:
Documento: |
Artículo
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Título: | Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma |
Autor: | Gazzaniga, S.; Bravo, A.I.; Mordoh, J.; Wainstok, R. |
Filiación: | Universidad de Buenos Aires Departamento de Química Biológica, FCEN, Ciudad Universitaria, Cd. Autónoma de Buenos Aires, Argentina Servicio de Inmunopatología, Hospital Eva Perón, San Martín, Buenos Aires, Argentina Instituto Leloir, Av. Patricias Argentinas 435, Cd. Autónoma de Buenos Aires, Argentina Dpto. de Química Biológica, FCEN, Ciudad Universitaria, 1428 Cd. Auton. de Buenos Aires, Argentina
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Palabras clave: | Angiogenesis; Macrophages; Melanoma; Monocyte chemoattractant protein-1 |
Año: | 2006
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Volumen: | 40
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Número: | 4
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Página de inicio: | 463
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Página de fin: | 467
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Título revista: | Acta Bioquimica Clinica Latinoamericana
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Título revista abreviado: | Acta Bioquim. Clin. Latinoam.
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ISSN: | 03252957
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CODEN: | ABCLD
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PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_03252957_v40_n4_p463_Gazzaniga.pdf |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga |
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Citas:
---------- APA ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J. & Wainstok, R.
(2006)
. Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma . Acta Bioquimica Clinica Latinoamericana, 40(4), 463-467.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]
---------- CHICAGO ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R.
"Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma "
. Acta Bioquimica Clinica Latinoamericana 40, no. 4
(2006) : 463-467.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]
---------- MLA ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R.
"Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma "
. Acta Bioquimica Clinica Latinoamericana, vol. 40, no. 4, 2006, pp. 463-467.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]
---------- VANCOUVER ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R. Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma . Acta Bioquim. Clin. Latinoam. 2006;40(4):463-467.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]