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Abstract:

Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with heterogeneity in the percentage of positive cells within the tumor mass. Tumors presented an important infiltration of macrophages, particularly associated to areas of active angiogenesis. Microvascular development, assessed by immunohistochemistry, correlated with the high percentage of cells expressing MCP-1/CCL-2. There was also significant correlation with vascularization and mitotic index. These results suggest that vascularization could be predictive of more aggressive melanoma metastasis, where the MCP-1/CCL-2 expression would be closely associated to vessel development through macrophages recruitment.

Registro:

Documento: Artículo
Título:Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
Autor:Gazzaniga, S.; Bravo, A.I.; Mordoh, J.; Wainstok, R.
Filiación:Universidad de Buenos Aires
Departamento de Química Biológica, FCEN, Ciudad Universitaria, Cd. Autónoma de Buenos Aires, Argentina
Servicio de Inmunopatología, Hospital Eva Perón, San Martín, Buenos Aires, Argentina
Instituto Leloir, Av. Patricias Argentinas 435, Cd. Autónoma de Buenos Aires, Argentina
Dpto. de Química Biológica, FCEN, Ciudad Universitaria, 1428 Cd. Auton. de Buenos Aires, Argentina
Palabras clave:Angiogenesis; Macrophages; Melanoma; Monocyte chemoattractant protein-1
Año:2006
Volumen:40
Número:4
Página de inicio:463
Página de fin:467
Título revista:Acta Bioquimica Clinica Latinoamericana
Título revista abreviado:Acta Bioquim. Clin. Latinoam.
ISSN:03252957
CODEN:ABCLD
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_03252957_v40_n4_p463_Gazzaniga.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga

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Citas:

---------- APA ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J. & Wainstok, R. (2006) . Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma . Acta Bioquimica Clinica Latinoamericana, 40(4), 463-467.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]
---------- CHICAGO ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R. "Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma " . Acta Bioquimica Clinica Latinoamericana 40, no. 4 (2006) : 463-467.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]
---------- MLA ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R. "Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma " . Acta Bioquimica Clinica Latinoamericana, vol. 40, no. 4, 2006, pp. 463-467.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]
---------- VANCOUVER ----------
Gazzaniga, S., Bravo, A.I., Mordoh, J., Wainstok, R. Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma . Acta Bioquim. Clin. Latinoam. 2006;40(4):463-467.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga [ ]