Corticosteroid action on rat spleen tissue was studied in order to determine the action of the hormone on cells involved in the early phase of the immune response. A significant reduction of plaque forming cells (PFC) was observed when the steroid was administered simultaneously with the antigen and even had some effect when injected up to three days after immunization. Inasmuch as it can be assumed that at a period of 72 hr or less a great number, if not all the cells, are challenged by the antigen, indicating a lympholytic action of the hormone on the already stimulated cells.
| Documento: | Artículo |
| Título: | Glucocorticoid action on rat spleen cells. I. Action of cortisone on antibody forming cells |
| Autor: | Rife, S.U. |
| Filiación: | Cent. Estud. Farmacol. Principios Naturales, Univ. Buenos Aires, Argentina |
| Palabras clave: | cortisone; cortisone acetate; hydrocortisone; animal experiment; antibody producing cell; antibody production; immune response; plaque forming cell; rat; spleen; spleen cell; Animal; Antibody Formation; Hydrocortisone; Male; Plaque Assay; Rats; Rats, Inbred Strains; Spleen; Support, Non-U.S. Gov't |
| Año: | 1978 |
| Volumen: | 28 |
| Número: | 6 |
| Página de inicio: | 315 |
| Página de fin: | 322 |
| Título revista: | Acta Physiologica Latino-Americana |
| Título revista abreviado: | ACTA PHYSIOL. LAT.-AM. |
| CODEN: | APLTA |
| CAS: | cortisone acetate, 50-04-4; cortisone, 53-06-5; hydrocortisone, 50-23-7; Hydrocortisone, 50-23-7 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18604_v28_n6_p315_Rife |
