Female Wistar rats when crowded together become aggressive if fed a diet with low tryptophan (Trp) content (maize flour, Mf). When isolated during 30 days and fed Mf, they show a decrease of weight, of total plasma Trp, and of Trp and 5-hydroxytryptamine (5-HT) in brain stem, but 5-hydroxyindolacetic acid (5-HIAA) of the same cerebral area does not change. These results partially agree with other authors' observations. Mice isolated during 47 days and fed with Mf do not show any significant weight variation, the hypermotility of isolated mice on normal diet persists, but 5-HT and 5-HIAA significantly decrease in total brain, an effect that has been observed by another author. The effect of 5-HIAA does not depend on the diet, either balanced or with low Trp content.
Documento: | Artículo |
Título: | Effect on rats and mice of a diet with low tryptophan content (maize flour) |
Autor: | Izquierdo, J.A.; Rabiller, G.; Maris Costas, S.; Justel, E.A.; Savini, C.V. |
Filiación: | Cent. Estud. Farmacol. Principios Naturales, CONICET, Buenos Aires, Argentina |
Palabras clave: | 5 hydroxyindoleacetic acid; brain monoamine; serotonin; tryptophan; aggression; animal experiment; brain stem; central nervous system; diet; drug blood level; mouse; oral drug administration; Aggression; Animals; Body Weight; Brain Stem; Diet; Female; Flour; Humans; Hydroxyindoleacetic Acid; Male; Mice; Rats; Rats, Inbred Strains; Serotonin; Tryptophan; Tryptophan Oxygenase; Zea mays |
Año: | 1979 |
Volumen: | 29 |
Número: | 4-5 |
Página de inicio: | 239 |
Página de fin: | 243 |
Título revista: | Acta Physiologica Latino-Americana |
Título revista abreviado: | ACTA PHYSIOL. LAT.-AM. |
CODEN: | APLTA |
CAS: | 5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; serotonin, 50-67-9; tryptophan, 6912-86-3, 73-22-3; Hydroxyindoleacetic Acid, 54-16-0; Serotonin, 50-67-9; Tryptophan, 73-22-3; Tryptophan Oxygenase, 1.13.11.11 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18561_v29_n4-5_p239_Izquierdo |