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Abstract:

Progesterone, epitestosterone (4-androstene-17 α-o1-3-one, EpiT) and 4- androstene-3-one-17β-carboxylic acid (COOH), three known in vitro inhibitors of 5α reductase, were injected daily for 30 days into male rats to study their effect on some parameters of epididymal function. Progesterone at a dose of 750 and 2000 μg/day decreased fertility by 59% and 50%, respectively. EpiT at a dose of 1 500 μg/day decreased fertility by 74%. These treatments did not change the sperm counts in the cauda epididynis. epididymis. with COOH did not decrease fertility. Progesterone at 750 and 2 000 μg/day and EpiT at 750 μg/day decreased the weight of the epididymis, prostate and seminal vesicles. None of the compounds tested produced variations in body weight or in the weight of liver and testis. The 5α reductase activity of epididymis, testis and liver was diminished by progesterone treatment, while EpiT decreased only that of testis and liver.

Registro:

Documento: Artículo
Título:Effect of in vivo administration of 5α reductase inhibitors on epididymal function
Autor:De Larminat, M.A.; Blaquier, J.A.
Filiación:Inst. Biol. Med. Exp., 1428 Buenos Aires, Argentina
Palabras clave:epitestosterone; progesterone; radioisotope; steroid reductase; 3 oxo 4 etienic acid; 5alpha androstane 3alpha,17beta diol c 14; androstanolone c 14; animal experiment; dose response; drug response; endocrine system; enzyme inhibition; epididymis; fertility; liver; male genital system; prostate; rat; seminal vesicle; spermatozoon count; testis; testosterone h 3; Animal; Body Weight; Epididymis; Epitestosterone; Female; Fertility; Genitalia, Male; Male; Organ Weight; Oxidoreductases; Pregnancy; Progesterone; Rats; Rats, Inbred Strains; Sperm Count; Support, Non-U.S. Gov't; Testosterone; Testosterone 5-alpha-Reductase
Año:1979
Volumen:29
Número:1
Página de inicio:1
Página de fin:6
Título revista:Acta Physiologica Latino-Americana
Título revista abreviado:ACTA PHYSIOL. LAT.-AM.
CODEN:APLTA
CAS:epitestosterone, 481-30-1; progesterone, 57-83-0; steroid reductase, 42616-29-5, 9082-73-9; Epitestosterone, 481-30-1; Oxidoreductases, EC 1.; Progesterone, 57-83-0; Testosterone 5-alpha-Reductase, EC 1.3.99.5; testosterone formate, 3129-42-8; Testosterone, 57-85-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat

Citas:

---------- APA ----------
De Larminat, M.A. & Blaquier, J.A. (1979) . Effect of in vivo administration of 5α reductase inhibitors on epididymal function. Acta Physiologica Latino-Americana, 29(1), 1-6.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat [ ]
---------- CHICAGO ----------
De Larminat, M.A., Blaquier, J.A. "Effect of in vivo administration of 5α reductase inhibitors on epididymal function" . Acta Physiologica Latino-Americana 29, no. 1 (1979) : 1-6.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat [ ]
---------- MLA ----------
De Larminat, M.A., Blaquier, J.A. "Effect of in vivo administration of 5α reductase inhibitors on epididymal function" . Acta Physiologica Latino-Americana, vol. 29, no. 1, 1979, pp. 1-6.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat [ ]
---------- VANCOUVER ----------
De Larminat, M.A., Blaquier, J.A. Effect of in vivo administration of 5α reductase inhibitors on epididymal function. ACTA PHYSIOL. LAT.-AM. 1979;29(1):1-6.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18557_v29_n1_p1_DeLarminat [ ]