In acute experiments aldosterone (aldo), 18-hydroxycorticosterone (18 OH B) or corticosterone (B) were administered to adrenalectomized rats and parameters related to acid-base balance determined in urine samples collected for 3.5 hours after injection. Aldo reduced sodium excretion but did not affect pH or the outputs of K, HN4+, CO3H-, phosphates, or titratable acidity. 18 OH B increased the excretion of titratable acidity and drastically reduced that of CO3H-. The lowest effective dose (3 μg) promoted Na excretion while the highest dose employed (6 μg) reduced pH and Na excretion. B increased the excretions of phosphates and ammonium, the former drastically. Potassium output either increased or did not change, and pH augmented marginally. It is postulated that a) 18 OH B is a naturally occurring steroid eliciting urine-acidification not necessarily accompanied by sodium retention; and b) in the rat B and 18OH B possess hormonal roles according to which the latter promotes the presence of protons, and the former, that of acute proton-acceptors in the lumen of tubuli.
| Documento: | Artículo |
| Título: | Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats |
| Autor: | Damasco, M.C.; Diaz, F.; Cenal, J.P.; Lantos, C.P. |
| Filiación: | Lab. Esteroides, Dept. Quim. Biol., Fac. Ci. Exactas Naturales, Univ. Buenos Aires, Argentina |
| Palabras clave: | 18 hydroxycorticosterone; aldosterone; corticosterone; potassium; triamcinolone; acid base balance; adrenalectomy; animal experiment; bladder; drug administration; drug comparison; drug efficacy; electrolyte urine level; endocrine system; kidney; rat; urine ph; 18-Hydroxycorticosterone; Acid-Base Equilibrium; Adrenal Cortex; Aldosterone; Ammonium Compounds; Animal; Bicarbonates; Comparative Study; Corticosterone; Kidney; Male; Phosphates; Potassium; Rats; Rats, Inbred Strains; Sodium; Support, Non-U.S. Gov't |
| Año: | 1979 |
| Volumen: | 29 |
| Número: | 6 |
| Página de inicio: | 305 |
| Página de fin: | 314 |
| Título revista: | Acta Physiologica Latino-Americana |
| Título revista abreviado: | ACTA PHYSIOL. LAT.-AM. |
| CODEN: | APLTA |
| CAS: | 18 hydroxycorticosterone, 561-65-9; aldosterone, 52-39-1, 6251-69-0; corticosterone, 50-22-6; potassium, 7440-09-7; triamcinolone, 124-94-7; 18-Hydroxycorticosterone, 561-65-9; Aldosterone, 52-39-1; Ammonium Compounds; Bicarbonates; Corticosterone, 50-22-6; Phosphates; Potassium, 7440-09-7; Sodium, 7440-23-5 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_NIS18555_v29_n6_p305_Damasco |
