Abstract:
Despite considerable progress, there is still no medical treatment available for some kinds of pituitary tumors, in particular hormone inactive adenomas and corticotroph pituitary tumors. Surgical removal or at least debulking of the tumor is the only option to treat these kinds of tumors apart from rarely applied radiotherapy. Moreover, treatment resistance is present in a considerable proportion of patients bearing pituitary tumors, for which medical treatment regimens are already available (prolactinomas, somatotroph adenomas). Thus, novel or improved medical treatment strategies would be desirable. Here, we summarize preclinical and clinical findings about the hormoneand growth-suppressive action of various drugs, which will probably lead to novel future medical treatment concepts for pituitary tumors. © 2010 S. Karger AG, Basel.
Registro:
Documento: |
Parte de libro
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Título: | Novel medical therapies for pituitary tumors |
Autor: | Theodoropoulou, M.; Labeur, M.; Paez Pereda, M.; Haedo, M.; Perone, M.J.; Renner, U.; Arzt, E.; Stalla, G.K. |
Filiación: | Max Planck Institute of Psychiatry, Department of Neuroendocrinology, Kraepelinstrasse 10, Munich, DE-80804, Germany Affectis Pharmaceuticals, Munich, Germany Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, Universidad de Buenos Aires and IFIBYNE-CONICET, Buenos Aires, Argentina
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Año: | 2010
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Volumen: | 38
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Página de inicio: | 158
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Página de fin: | 164
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DOI: |
http://dx.doi.org/10.1159/000318506 |
Título revista: | Pituitary Today II: New Molecular, Physiological and Clinical Aspects
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Título revista abreviado: | Pituit. Today II: New Mol., Physiol. and Clin. Asp.
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97838055_v38_n_p158_Theodoropoulou |
Referencias:
- Mancini, T., Casanueva, F.F., Giustina, A., Hyperprolactinemia and prolactinomas (2008) Endocrinol Metab Clin North Am, 37, pp. 67-99
- Renner, U., Arzberger, T., Pagotto, U., Leimgruber, S., Uhl, E., Müller, A., Lange, M., Stalla, G.K., Heterogeneous dopamine D2 receptor subtype messenger ribonucleic acid expression in clinically nonfunctioning pituitary adenomas (1998) J Clin Endocrinol Metab, 83, pp. 1368-1375
- Pivonelle, R., Matrone, C., Filippella, M., Cavallo, L.M., Di Somma, C., Cappabianca, P., Colao, A., Lombardi, G., Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors: comparison with the effectiveness of cabergoline treatment (2004) J Clin Endocrinol Metab, 89, pp. 1674-1683
- Petrossians, P., Ronci, N., Valdes Socin, H., Kalife, A., Stevenaert, A., Bloch, B., Tabarin, A., Beckers, A., ACTH silent adenoma shrinking under cabergoline (2001) Eur J Endocrinol, 144, pp. 51-57
- Pivonello, R., Ferone, D., de Herder, W.W., Kros, J.M., De Caro, M.L., Arvigo, M., Annunziato, L., Lamberts, S.W., Dopamine receptor expression and function in corticotroph pituitary tumors (2004) J Clin Endocrinol Metab, 89, pp. 2452-2462
- De Bruin, C., Hanson, J.M., Meij, B.P., Kooistra, H.S., Waaijers, A.M., Uitterlinden, P., Lamberts, S.W.J., Hofland, L.J., Expression and functional analysis of dopamine receptor subtype 2 and somatostatin receptor subtypes in canine cushing's disease (2008) Endocrinology, 149, pp. 4357-4366
- Greenman, Y., Tordjman, K., Osher, E., Veshchev, I., Shenkerman, G., Reider-Groswasser, I.I., Shegev, Y., Stern, N., Postoperative treatment of clinically nonfunctioning pituitary adenomas with dopamine agonists decreases tumour remnant growth (2005) Clin Endocrinol, 63, pp. 39-44
- Lohmann, T., Trantakis, C., Biesold, M., Prothman, S., Guenzel, S., Schober, R., Paschke, R., Minor tumour shrinkage in nonfunctioning pituitary adenomas by long-term treatment with the dopamine agonist cabergoline (2001) Pituitary, 4, pp. 173-178
- Weckbecker, G., Lewis, I., Albert, R., Schmid, H.A., Hoyer, D., Bruns, C., Opportunities in somatostatin research: biological, chemical and therapeutic aspects (2003) Nat Rev Drug Discov, 2, pp. 999-1017
- Freda, P.U., Katznelson, L., van der Lely, A.J., Reyes, C.M., Zhao, S., Rabinowitz, D., Long-acting somatostatin analog therapy of acromegaly: a meta-analysis (2005) J Clin Endocrinol Metab, 90, pp. 4465-4473
- Patel, Y.C., Greenwood, M.T., Panetta, R., Demchyshyn, L., Niznik, H., Srikant, C.B., The somatostatin receptor family (1995) Life Sci, 57, pp. 1249-1265
- Lewis, I., Bauer, W., Albert, R., Chandramouli, N., Pless, J., Weckbecker, G., Bruns, C., A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential (2003) J Med Chem, 46, pp. 2334-2344
- Schmid, H.A., Pasireotide (SOM230): development, mechanism of action and potential applications (2008) Mol Cell Endocrinol, 286, pp. 69-74
- Hofland, L.J., van der Hoek, J., Feelders, R., van Aken, M.O., van Koetsveld, P.M., Waaijers, M., Sprij-Mooij, D., Lamberts, S.W., The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5 (2005) Eur J Endocrinol., 152, pp. 645-654
- Batista, D.L., Zhang, X., Gejman, R., Ansell, P.J., Zhou, Y., Johnson, S.A., Swearingen, B., Klibanski, A., The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas (2006) J Clin Endocrinol Metab, 91, pp. 4482-4488
- Van der Hoek, J., Waaijers, M., van Koetsveld, P.M., Sprij-Mooij, D., Feelders, R.A., Schmid, H.A., Schoeffter, P., Hofland, L.J., Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells (2005) Am J Physiol Endocrinol Metab, 289, pp. E278-E287
- Boscaro, M., Ludlam, W.H., Atkinson, B., Glusman, J.E., Petersenn, S., Reincke, M., Snyder, P., Bertherat, J., Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial (2009) J Clin Endocrinol Metab, 94, pp. 115-122
- Rocheville, M., Lange, D.C., Kumar, U., Patel, S.C., Patel, R.C., Patel, Y.C., Receptors for dopamine and somatostatin:formation of hetero-oligomers with enhanced functional activity (2000) Science., 288, pp. 154-157
- Saveanu, A., Lavaque, E., Gunz, G., Barlier, A., Kim, S., Taylor, J.E., Culler, M.D., Jaquet, P., Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells (2002) J Clin Endocrinol Metab, 87, pp. 5545-5552
- Greenman, Y., Melmed, S., Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors (1994) J Clin Endocrinol Metab, 78, pp. 398-403
- Bevan, J.S., Webster, J., Burke, C.W., Scanlon, M.F., Dopamine agonists and pituitary tumor shrinkage (1992) Endocr Rev, 13, pp. 220-240
- De Bruin, T.W., Kwekkeboom, D.J., Van't Verlaat, J.W., Reubi, J.C., Krenning, E.P., Lamberts, S.W., Croughs, R.J., Clinically nonfunctioning pituitary adenoma and octreotide response to long term high dose treatment, and studies in vitro (1992) J Clin Endocrinol Metab, 75, pp. 1310-1317
- Katznelson, L., Oppenheim, D.S., Coughlin, J.F., Kliman, B., Schoenfeld, D.A., Klibanski, A., Chronic somatostatin analog administration in patients with alpha-subunit-secreting pituitary tumors (1992) J Clin Endocrinol Metab, 75, pp. 1318-1325
- Florio, T., Barbieri, F., Spaziante, R., Zona, G., Hofland, L.J., van Koetsveld, P.M., Feelders, R.A., Jaquet, P., Efficacy of a dopamine-somatostatin chimeric molecule and BIM-23A760 and in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study (2008) Endocr Relat Cancer, 15, pp. 583-596
- Newell-Price, J., Bertagna, X., Grossman, A.B., Nieman, L.K., Cushing's syndrome (2006) Lancet, 367, pp. 1605-1617
- Chambon, P., A decade of molecular biology of retinoic acid receptors (1996) FASEB J, 10, pp. 940-954
- Zang, X.K., Hoffmann, B., Tran, P.B., Graupner, G., Pfahl, M., Retinoid X receptor is an auxiliary protein of thyroid hormone and retinoic acid receptors (1992) Nature, 355, pp. 441-446
- Páez-Pereda, M., Kovalovsky, D., Hopfner, U., Theodoropoulou, M., Pagotto, U., Uhl, E., Losa, M., Stalla, G.K., Retinoic acid prevents experimental Cushing syndrome (2001) J Clin Invest, 108, pp. 1123-1131
- Castillo, V., Giacomini, D., Páez-Pereda, M., Stalla, J., Labeur, M., Theodoropoulou, M., Holsboer, F., Arzt, E., Retinoic acid as a novel medical therapy for Cushing's disease in dogs (2006) Endocrinology, 147, pp. 4438-4444
- Labeur, M., Refojo, D., Wölfel, B., Stalla, J., Vargas, V., Theodoropoulou, M., Buchfelder, M., Stalla, G.K., Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel Janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway (2008) J Endocrinol, 199, pp. 177-189
- Miller, M., Chen, S., Woodliff, J., Kansra, S., Curcumin (diferuloylmethane) nhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells (2008) Endocrinology, 149, pp. 4158-4167
- Vlotides, G., Siegel, E., Donangelo, I., Gutman, S., Ren, S.G., Melmed, S., Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands (2008) Cancer Res, 68, pp. 6377-6386
Citas:
---------- APA ----------
Theodoropoulou, M., Labeur, M., Paez Pereda, M., Haedo, M., Perone, M.J., Renner, U., Arzt, E.,..., Stalla, G.K.
(2010)
. Novel medical therapies for pituitary tumors. Pituitary Today II: New Molecular, Physiological and Clinical Aspects, 38, 158-164.
http://dx.doi.org/10.1159/000318506---------- CHICAGO ----------
Theodoropoulou, M., Labeur, M., Paez Pereda, M., Haedo, M., Perone, M.J., Renner, U., et al.
"Novel medical therapies for pituitary tumors"
. Pituitary Today II: New Molecular, Physiological and Clinical Aspects 38
(2010) : 158-164.
http://dx.doi.org/10.1159/000318506---------- MLA ----------
Theodoropoulou, M., Labeur, M., Paez Pereda, M., Haedo, M., Perone, M.J., Renner, U., et al.
"Novel medical therapies for pituitary tumors"
. Pituitary Today II: New Molecular, Physiological and Clinical Aspects, vol. 38, 2010, pp. 158-164.
http://dx.doi.org/10.1159/000318506---------- VANCOUVER ----------
Theodoropoulou, M., Labeur, M., Paez Pereda, M., Haedo, M., Perone, M.J., Renner, U., et al. Novel medical therapies for pituitary tumors. Pituit. Today II: New Mol., Physiol. and Clin. Asp. 2010;38:158-164.
http://dx.doi.org/10.1159/000318506