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Abstract:

p53 is a widely conserved tumor suppressor protein that is frequently inactivated in human cancer. p53 functions primarily as a transcription factor regulating the expression of a growing repertoire of target genes. p53 integrates signals from many stress-activated pathways and is subject to multiple posttranslational modifications. Phosphorylation and acetylation have been implicated in the regulation of p53 stability and activity. In response to DNA damage, hypoxia, oncogene activation and other types of stress, activated p53 triggers a variety of cellular programs, often in a stimuli- and cell type-specific manner. In particular, the role of p53 in cell growth arrest and apoptosis is criticial for its tumor suppressor activity. © 2010 Springer-Verlag Berlin Heidelberg.

Registro:

Documento: Parte de libro
Título:Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis
Autor:Giono, L.E.; Manfredi, J.J.
Filiación:Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, United States
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Año:2010
Página de inicio:375
Página de fin:395
DOI: http://dx.doi.org/10.1007/978-3-642-02112-1_20
Título revista:Signal Transduction: Pathways, Mechanisms and Diseases
Título revista abreviado:Sign. Transduction: Pathways, Mechanisms and Dis.
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97836420_v_n_p375_Giono

Referencias:

  • Anderson, M.E., Woelker, B., Reed, M., Wang, P., Tegtmeyer, P., Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: Implications for regulation (1997) Mol Cell Biol, 17 (11), pp. 6255-6264
  • Ando, T., Kawabe, T., Ohara, H., Ducommun, B., Itoh, M., Okamoto, T., Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage (2001) J Biol Chem, 276 (46), pp. 42971-42977
  • Appella, E., Anderson, C.W., Post-translational modifications and activation of p53 by genotoxic stresses (2001) Eur J Biochem, 268 (10), pp. 2764-2772
  • Asher, G., Shaul, Y., P53 Proteasomal degradation: Poly-ubiquitination is not the whole story (2005) Cell Cycle, 4 (8), pp. 229-232
  • Bargonetti, J., Manfredi, J.J., Multiple roles of the tumor suppressor p53 (2002) Curr Opin Oncol, 14 (1), pp. 86-91
  • Barlev, N.A., Liu, L., Chehab, N.H., Mansfield, K., Harris, K.G., Halazonetis, T.D., Berger, S.L., Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases (2001) Molecular Cell, 8 (6), pp. 1243-1254
  • Bartek, J., Lukas, J., Mammalian G1- and S-phase checkpoints in response to DNA damage (2001) Curr Opin Cell Biol, 13 (6), pp. 738-747
  • Bartek, J., Lukas, J., Pathways governing G1/S transition and their response to DNA damage (2001) FEBS Lett, 490 (3), pp. 117-122
  • Bartek, J., Lukas, C., Lukas, J., Checking on DNA damage in S phase (2004) Nat Rev Mol Cell Biol, 5 (10), pp. 792-804
  • Bensaad, K., Vousden, K.H., P53: New roles in metabolism (2007) Trends in Cell Biology, 17 (6), pp. 286-291
  • Bischoff, J.R., Kirn, D.H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., McCormick, F., An adenovirus mutant that replicates selectively in p53- deficient human tumor cells (1996) Science, 274 (5286), pp. 373-376
  • Bode, A.M., Dong, Z., Post-translational modification of p53 in tumorigenesis (2004) Nat Rev Cancer, 4 (10), pp. 793-805
  • Bottger, A., Bottger, V., Sparks, A., Liu, W.L., Howard, S.F., Lane, D.P., Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo (1997) Curr Biol, 7 (11), pp. 860-869
  • Brooks, C.L., Gu, W., Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation (2003) Curr Opin Cell Biol, 15 (2), pp. 164-171
  • Brooks, C.L., Gu, W., P53 ubiquitination: Mdm2 and beyond (2006) Molecular Cell, 21 (3), pp. 307-315
  • Carvajal, D., Tovar, C., Yang, H., Vu, B.T., Heimbrook, D.C., Vassilev, L.T., Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors (2005) Cancer Res, 65 (5), pp. 1918-1924
  • Charrier-Savournin, F.B., Chateau, M.T., Gire, V., Sedivy, J., Piette, J., Dulic, V., P21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress (2004) Mol Biol Cell, 15 (9), pp. 3965-3976
  • Chuikov, S., Kurash, J.K., Wilson, J.R., Xiao, B., Justin, N., Ivanov, G.S., McKinney, K., Reinberg, D., Regulation of p53 activity through lysine methylation (2004) Nature, 432 (7015), pp. 353-360
  • Crighton, D., Wilkinson, S., Ryan, K.M., DRAM links autophagy to p53 and programmed cell death (2007) Autophagy, 3 (1), pp. 72-74
  • El-Deiry, W.S., Regulation of p53 downstream genes (1998) Semin Cancer Biol, 8 (5), pp. 345-357
  • Espinosa, J.M., Mechanisms of regulatory diversity within the p53 transcriptional network (2008) Oncogene, 27 (29), pp. 4013-4023
  • Fridman, J.S., Lowe, S.W., Control of apoptosis by p53 (2003) Oncogene, 22 (56), pp. 9030-9040
  • Gottifredi, V., Prives, C., The S phase checkpoint: When the crowd meets at the fork (2005) Semin Cell Dev Biol, 16 (3), pp. 355-368
  • Grossman, S.R., Deato, M.E., Brignone, C., Chan, H.M., Kung, A.L., Tagami, H., Nakatani, Y., Livingston, D.M., Polyubiquitination of p53 by a ubiquitin ligase activity of p300 (2003) Science, 300 (5617), pp. 342-344
  • Gu, W., Roeder, R.G., Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain (1997) Cell, 90 (4), pp. 595-606
  • Halaby, M.J., Yang, D.Q., P53 translational control: A new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics (2007) Gene, 395 (1-2), pp. 1-7
  • Harris, C.C., P53 tumor suppressor gene: From the basic research laboratory to the clinic- an abridged historical perspective (1996) Carcinogenesis, 17 (6), pp. 1187-1198
  • He, L., He, X., Lowe, S.W., Hannon, G.J., MicroRNAs join the p53 network-another piece in the tumour-suppression puzzle (2007) Nat Rev Cancer, 7 (11), pp. 819-822
  • Ho, J.S., Ma, W., Mao, D.Y., Benchimol, S., P53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest (2005) Mol Cell Biol, 25 (17), pp. 7423-7431
  • Hupp, T.R., Meek, D.W., Midgley, C.A., Lane, D.P., Regulation of the specific DNA binding function of p53 (1992) Cell, 71 (5), pp. 875-886
  • Ito, A., Lai, C.H., Zhao, X., Saito, S., Hamilton, M.H., Appella, E., Yao, T.P., P300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2 (2001) Embo J, 20 (6), pp. 1331-1340
  • Jackson, M.W., Agarwal, M.K., Agarwal, M.L., Agarwal, A., Stanhope-Baker, P., Williams, B.R., Stark, G.R., Limited role of N-terminal phosphoserine residues in the activation of transcription by p53 (2004) Oncogene, 23 (25), pp. 4477-4487
  • Jin, S., Tong, T., Fan, W., Fan, F., Antinore, M.J., Zhu, X., Mazzacurati, L., Zhan, Q., GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity (2002) Oncogene, 21 (57), pp. 8696-8704
  • Jin, Y., Zeng, S.X., Dai, M.S., Yang, X.J., Lu, H., MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation (2002) J Biol Chem, 277 (34), pp. 30838-30843
  • Kaeser, M.D., Iggo, R.D., Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo (2002) Proc Natl Acad Sci USA, 99 (1), pp. 95-100
  • Kawai, H., Nie, L., Wiederschain, D., Yuan, Z.M., Dual role of p300 in the regulation of p53 stability (2001) J Biol Chem, 276 (49), pp. 45928-45932
  • Keller, D.M., Zeng, X., Wang, Y., Zhang, Q.H., Kapoor, M., Shu, H., Goodman, R., Lu, H., A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1 (2001) Molecular Cell, 7 (2), pp. 283-292
  • Krummel, K.A., Lee, C.J., Toledo, F., Wahl, G.M., The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation (2005) Proc Natl Acad Sci USA, 102 (29), pp. 10188-10193
  • Lane, D.P., Cancer. p53, guardian of the genome (1992) Nature, 358 (6381), pp. 15-16
  • Levine, A.J., P53, the cellular gatekeeper for growth and division (1997) Cell, 88 (3), pp. 323-331
  • Marine, J.C., Jochemsen, A.G., Mdmx and Mdm2: Brothers in arms? (2004) Cell Cycle, 3 (7), pp. 900-904
  • McKinney, K., Mattia, M., Gottifredi, V., Prives, C., P53 linear diffusion along DNA requires its C terminus (2004) Molecular Cell, 16 (3), pp. 413-424
  • Meek, D.W., Knippschild, U., Posttranslational modification of MDM2 (2003) Mol Cancer Res, 1 (14), pp. 1017-1026
  • Meulmeester, E., Pereg, Y., Shiloh, Y., Jochemsen, A.G., ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation (2005) Cell Cycle, 4 (9), pp. 1166-1170
  • Midgley, C.A., Desterro, J.M., Saville, M.K., Howard, S., Sparks, A., Hay, R.T., Lane, D.P., An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo (2000) Oncogene, 19 (19), pp. 2312-2323
  • Mills, A.A., Zheng, B., Wang, X.J., Vogel, H., Roop, D.R., Bradley, A., P63 is a p53 homologue required for limb and epidermal morphogenesis (1999) Nature, 398 (6729), pp. 708-713
  • Moll, U.M., Petrenko, O., The MDM2-p53 interaction (2003) Mol Cancer Res, 1 (14), pp. 1001-1008
  • Montagnoli, A., Tenca, P., Sola, F., Carpani, D., Brotherton, D., Albanese, C., Santocanale, C., Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells (2004) Cancer Res, 64 (19), pp. 7110-7116
  • Muller, S., Berger, M., Lehembre, F., Seeler, J.S., Haupt, Y., Dejean, A., C-Jun and p53 activity is modulated by SUMO-1 modification (2000) J Biol Chem, 275 (18), pp. 13321-13329
  • Murphy, M.E., Polymorphic variants in the p53 pathway (2006) Cell Death Differ, 13 (6), pp. 916-920
  • Murray-Zmijewski, F., Lane, D.P., Bourdon, J.C., P53/p63/p73 isoforms: An orchestra of isoforms to harmonise cell differentiation and response to stress (2006) Cell Death Differ, 13 (6), pp. 962-972
  • Nghiem, P., Park, P.K., Kim Ys, Y.S., Desai, B.N., Schreiber, S.L., ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint (2002) J Biol Chem, 277 (6), pp. 4428-4434
  • Nyberg, K.A., Michelson, R.J., Putnam, C.W., Weinert, T.A., Toward maintaining the genome: DNA damage and replication checkpoints (2002) Annu Rev Genet, 36, pp. 617-656
  • Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Taya, Y., P53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 (2000) Cell, 102 (6), pp. 849-862
  • Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W., Vogelstein, B., Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 (1993) Nature, 362 (6423), pp. 857-860
  • Olsson, A., Manzl, C., Strasser, A., Villunger, A., How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? (2007) Cell Death Differ, 14 (9), pp. 1561-1575
  • Oren, M., Decision making by p53: Life, death and cancer (2003) Cell Death Differ, 10 (4), pp. 431-442
  • Ou, Y.H., Chung, P.H., Sun, T.P., Shieh, S.Y., P53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation (2005) Mol Biol Cell, 16 (4), pp. 1684-1695
  • Paris, R., Henry, R.E., Stephens, S.J., McBryde, M., Espinosa, J.M., Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation (2008) Cell Cycle, 7 (15), pp. 2427-2433
  • Pereg, Y., Shkedy, D., De Graaf, P., Meulmeester, E., Edelson-Averbukh, M., Salek, M., Biton, S., Shiloh, Y., Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage (2005) Proc Natl Acad Sci USA, 102 (14), pp. 5056-5061
  • Piwnica-Worms, H., Cell Cycle (1999) Fools Rush In. Nature, 401 (6753), pp. 535-537
  • Rieder, C.L., Maiato, H., Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint (2004) Dev Cell, 7 (5), pp. 637-651
  • Rodriguez, M.S., Desterro, J.M., Lain, S., Midgley, C.A., Lane, D.P., Hay, R.T., SUMO-1 modification activates the transcriptional response of p53 (1999) Embo J, 18 (22), pp. 6455-6461
  • Sabbatini, P., McCormick, F., MDMX inhibits the p300/CBP-mediated acetylation of p53 (2002) DNA Cell Biol, 21 (7), pp. 519-525
  • Saito, S., Goodarzi, A.A., Higashimoto, Y., Noda, Y., Lees-Miller, S.P., Appella, E., Anderson, C.W., ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation (2002) J Biol Chem, 277 (15), pp. 12491-12494
  • Sakaguchi, K., Herrera, J.E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C.W., Appella, E., DNA damage activates p53 through a phosphorylation-acetylation cascade (1998) Genes Dev, 12 (18), pp. 2831-2841
  • Schuler, M., Green, D.R., Transcription, apoptosis and p53: Catch-22 (2005) Trends Genet, 21 (3), pp. 182-187
  • Selivanova, G., Kawasaki, T., Ryabchenko, L., Wiman, K.G., Reactivation of mutant p53: A new strategy for cancer therapy (1998) Semin Cancer Biol, 8 (5), pp. 369-378
  • Shaulsky, G., Goldfinger, N., Tosky, M.S., Levine, A.J., Rotter, V., Nuclear localization is essential for the activity of p53 protein (1991) Oncogene, 6 (11), pp. 2055-2065
  • Sherr, C.J., G1 phase progression: Cycling on cue (1994) Cell, 79 (4), pp. 551-555
  • Sionov, R.V., Haupt, Y., The cellular response to p53: The decision between life and death (1999) Oncogene, 18 (45), pp. 6145-6157
  • Stavridi, E.S., Chehab, N.H., Malikzay, A., Halazonetis, T.D., Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest (2001) Cancer Res, 61 (19), pp. 7030-7033
  • Stewart, Z.A., Pietenpol, J.A., P53 Signaling and cell cycle checkpoints (2001) Chem Res Toxicol, 14 (3), pp. 243-263
  • Strano, S., Dellorso, S., Di Agostino, S., Fontemaggi, G., Sacchi, A., Blandino, G., Mutant p53: An oncogenic transcription factor (2007) Oncogene, 26 (15), pp. 2212-2219
  • Taylor, W.R., Stark, G.R., Regulation of the G2/M transition by p53 (2001) Oncogene, 20 (15), pp. 1803-1815
  • Taylor, W.R., Agarwal, M.L., Agarwal, A., Stacey, D.W., Stark, G.R., P53 inhibits entry into mitosis when DNA synthesis is blocked (1999) Oncogene, 18 (2), pp. 283-295
  • Teodoro, J.G., Evans, S.K., Green, M.R., Inhibition of tumor angiogenesis by p53: A new role for the guardian of the genome (2007) J Mol Med (Berlin, Germany), 85 (11), pp. 1175-1186
  • Thompson, T., Tovar, C., Yang, H., Carvajal, D., Vu, B.T., Xu, Q., Wahl, G.M., Vassilev, L.T., Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis (2004) J Biol Chem, 279 (51), pp. 53015-53022
  • Vassilev, L.T., Vu, B.T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Liu, E.A., In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 (2004) Science, 303 (5659), pp. 844-848
  • Vogel, C., Kienitz, A., Hofmann, I., Muller, R., Bastians, H., Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy (2004) Oncogene, 23 (41), pp. 6845-6853
  • Vogelstein, B., Lane, D., Levine, A.J., Surfing the p53 network (2000) Nature, 408 (6810), pp. 307-310
  • Vousden, K.H., P53: Death Star (2000) Cell, 103 (5), pp. 691-694
  • Vousden, K.H., Lu, X., Live or let die: The cells response to p53 (2002) Nat Rev Cancer, 2 (8), pp. 594-604
  • Wang, Y., Prives, C., Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases (1995) Nature, 376 (6535), pp. 88-91
  • Wang, X.W., Zhan, Q., Coursen, J.D., Khan, M.A., Kontny, H.U., Yu, L., Hollander, M.C., Harris, C.C., GADD45 induction of a G2/M cell cycle checkpoint (1999) Proc Natl Acad Sci USA, 96 (7), pp. 3706-3711
  • Wang, Y.H., Tsay, Y.G., Tan, B.C., Lo, W.Y., Lee, S.C., Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305 (2003) J Biol Chem, 278 (28), pp. 25568-25576
  • Waterman, M.J., Stavridi, E.S., Waterman, J.L., Halazonetis, T.D., ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins (1998) Nat Genet, 19 (2), pp. 175-178
  • Webley, K., Bond, J.A., Jones, C.J., Blaydes, J.P., Craig, A., Hupp, T., Wynford-Thomas, D., Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage (2000) Mol Cell Biol, 20 (8), pp. 2803-2808
  • Xirodimas, D.P., Saville, M.K., Bourdon, J.C., Hay, R.T., Lane, D.P., Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity (2004) Cell, 118 (1), pp. 83-97
  • Yang, A., McKeon, F., P63 and P73: P53 mimics, menaces and more (2000) Nat Rev Mol Cell Biol, 1 (3), pp. 199-207
  • Zhu, Y., Alvarez, C., Doll, R., Kurata, H., Schebye, X.M., Parry, D., Lees, E., Intra-S-phase checkpoint activation by direct CDK2 inhibition (2004) Mol Cell Biol, 24 (14), pp. 6268-6277

Citas:

---------- APA ----------
Giono, L.E. & Manfredi, J.J. (2010) . Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis. Signal Transduction: Pathways, Mechanisms and Diseases, 375-395.
http://dx.doi.org/10.1007/978-3-642-02112-1_20
---------- CHICAGO ----------
Giono, L.E., Manfredi, J.J. "Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis" . Signal Transduction: Pathways, Mechanisms and Diseases (2010) : 375-395.
http://dx.doi.org/10.1007/978-3-642-02112-1_20
---------- MLA ----------
Giono, L.E., Manfredi, J.J. "Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis" . Signal Transduction: Pathways, Mechanisms and Diseases, 2010, pp. 375-395.
http://dx.doi.org/10.1007/978-3-642-02112-1_20
---------- VANCOUVER ----------
Giono, L.E., Manfredi, J.J. Activation of the p53 tumor suppressor and its multiple roles in cell cycle and apoptosis. Sign. Transduction: Pathways, Mechanisms and Dis. 2010:375-395.
http://dx.doi.org/10.1007/978-3-642-02112-1_20