Abstract:
To attain a reliable outcome in electric field-based tumor treatments, dose planning is a must, and dose planning, in turn, requires establishing the dose-response relationship. But finding reliable dose and response parameters implies analyzing the electric field-tissue interaction, in particular, the inevitable appearance of complex electrolytic mass transfer processes and the inherent tissue damage. This review of electric field-based tumor treatments highlights the fundamental role played by the mass transfer of electrolytic species in the dose-response relationship. During the electrolysis process in electric field-based tumor treatments, electrochemical reactions take place at the electrodes, producing at the anode oxygen, chlorine, and protons as the main by-products, while hydrogen and hydroxide ions are released at the cathode. Proton and hydroxyls generation yields strong pH fronts. Since these fronts are the main product of electrolytic reactions, it is reasonable to assume that they are the main cause of tissue damage. The amount of electrolytic products emerging from chemical reactions is proportional to the amount of electric charges or Coulomb dose passing through the tissue; thus, Coulomb dose is proportional to tissue damage. Theory shows that in a constant electric field such as in electrolytic ablation, an optimal dose-response relationship is the minimum Coulomb dose necessary to achieve total tumor destruction while minimizing healthy tissue damage. In a pulsed electric field such as in gene electrotransfer, unwanted damage due to electrolysis is non-negligible; here, an optimal gene electrotransfer treatment is predicted as the critical Coulomb dose yielding maximum electroporated area with minimum damage. Theory shows that when tissue natural buffer is taken into account, damage is attenuated (though still remaining non-negligible), and the critical Coulomb dose for optimal gene electrotransfer increases. © Springer International Publishing AG 2017. All rights are reserved.
Registro:
| Documento: |
Parte de libro
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| Título: | Mass transfer of electrolytic species during electric field-based tumor treatments |
| Autor: | Marshall, G. |
| Filiación: | Laboratorio de Sistemas Complejos, Departamento de Computación, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Física del Plasma, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
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| Palabras clave: | Buffer natural system; Dose planning methodology; Dose-response relationship; Electrochemotherapy; Electrolytic ablation; Gene electrotransfer; Irreversible electroporation; Mathematical modeling |
| Año: | 2017
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| Volumen: | 1
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| Página de inicio: | 589
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| Página de fin: | 606
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| DOI: |
http://dx.doi.org/10.1007/978-3-319-32886-7_68 |
| Título revista: | Handbook of Electroporation
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| Título revista abreviado: | Handb. of Electroporation
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| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97833193_v1_n_p589_Marshall |
Referencias:
- Chiarella, P., Fazio, V.M., Signori, E., Application of electroporation in DNA vaccination protocols (2010) Curr Gene Ther, 10, pp. 281-286. , PMID: 20504275
- Colombo, L., Gonzalez, G., Marshall, G., Molina, F., Soba, A., Suarez, C., Turjanski, P., Ion transport in tumors under electrochemical treatment: in vivo, in vitro, and in silico modeling (2007) Bioelectrochemistry, 71, pp. 223-232
- Davalos, R., Mir, L., Rubinsky, B., Tissue ablation with irreversible electroporation (2005) Ann Biomed Eng, 33, pp. 223-231
- Li, J.H., Xin, Y.L., Zhang, W., Liu, J.T., Quan, K.H., Effect of electroacupuncture in treating patients with a lingual hemangioma (2006) Chin J Integr Med, 12 (2), pp. 146-149
- Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., Marshall, G., Optimal doseresponse relationship in electrolytic ablation of tumors with a one-probe-two-electrode device (2015) Electrochim Acta, 186, pp. 494-503
- Maglietti, F., Michinski, S., Olaiz, N., Castro, M., Suárez, C., Marshall, G., The role of Ph fronts in tissue electroporation-based treatments (2013) PLoS One, 8 (11)
- Marino, M., Olaiz, N., Signori, E., Maglietti, F., Suarez, C., Colombo, L., Turjanski, P., Marshall, G., Tissue damage in vaccination protocols based on electroporation: pH fronts and tissue natural buffering (2014) 14th International Conference on Progress In Vaccination against Cancer PIVAC 14, , http://docplayer.net/6456060-Pivac-14-the-14-th-international-conference-on-progress-in-vaccination-against-cancer-24-26-september-2014-rome-italy.html#show_full_text, Poster No. 22, Rome, Italy, in
- Marshall, G., Biomedical applications of electrochemistry, use of electric fields in cancer therapy (2014) Encyclopedia of Applied Electrochemistry, , In: Savinell RF, Ota K, Kreysa G (eds) Springer, New York
- McMahon, J.M., Signori, E., Wells, K.E., Fazio, V.M., Wells, D.J., Optimization of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase - increased expression with reduced muscle damage (2001) Gene Ther, 8, pp. 1264-1270
- Nilsson, E., Modeling of the electrochemical treatment of tumors (2000), PhD thesis, Department of Chemical Engineering and Technology, Applied Electrochemistry, Royal Institute of Technology; Nordenström, B., Biologically closed electrical circuits: clinical, experimental and theoretical evidence for an additional circulatory system (1983), Nordic Medical Publications, Stockholm; Olaiz, N., Suarez, C., Risk, M., Molina, F.V., Marshall, G., Tracking protein electrodenaturation fronts in the electrochemical treatment of tumors (2010) Electrochem Commun, 12, pp. 94-97
- Olaiz, N., Maglietti, F., Suárez, C., Molina, F.V., Miklavcic, D., Mir, L., Marshall, G., Electrochemical treatment of tumors using a one-probe two-electrode device (2010) Electrochim Acta, 55, pp. 6010-6014
- Olaiz, N., Signori, E., Maglietti, F., Soba, A., Suárez, C., Turjanski, P., Michinski, S., Marshall, G., Tissue damage modeling in plasmid gene electrotransfer: the role of pH (2014) Bioelectrochemistry, 100, pp. 105-111
- Saulis, G., Lape, R., Prabeviciute, R., Mickevicius, D., Changes of the solution pH due to exposure by high-voltage electric pulses (2005) Bioelectrochemistry, 67, pp. 101-108
- Suárez, C., Soba, A., Maglietti, F., Olaiz, N., Marshall, G., The role of additional pulses in electropermeabilization protocols (2014) PLoS One, 9 (12)
- Turjanski, P., Olaiz, N., Maglietti, F., Michinski, S., Suarez, C., Molina, F.V., Marshall, G., The role of pH fronts in reversible electroporation (2011) PLoS One, 6 (4)
Citas:
---------- APA ----------
(2017)
. Mass transfer of electrolytic species during electric field-based tumor treatments. Handbook of Electroporation, 1, 589-606.
http://dx.doi.org/10.1007/978-3-319-32886-7_68---------- CHICAGO ----------
Marshall, G.
"Mass transfer of electrolytic species during electric field-based tumor treatments"
. Handbook of Electroporation 1
(2017) : 589-606.
http://dx.doi.org/10.1007/978-3-319-32886-7_68---------- MLA ----------
Marshall, G.
"Mass transfer of electrolytic species during electric field-based tumor treatments"
. Handbook of Electroporation, vol. 1, 2017, pp. 589-606.
http://dx.doi.org/10.1007/978-3-319-32886-7_68---------- VANCOUVER ----------
Marshall, G. Mass transfer of electrolytic species during electric field-based tumor treatments. Handb. of Electroporation. 2017;1:589-606.
http://dx.doi.org/10.1007/978-3-319-32886-7_68