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Abstract:

Some decades ago it was postulated that gene expression regulation is required for long-term memory storage. In the last years, important progress has been made towards the characterization of these mechanisms of transcription. Among them, transcription factors play a key role. This chapter describes the characteristics and the role of one of these transcription factors, NF-κB, in the different phases of memory formation and processing. In more than a decade of research since the first data on the role of NF-κB in neuronal plasticity and memory, a growing body of evidence supports that this transcription factor is involved not only in the formation of the initial long-term memory traces but in the re-stabilization after memory reactivation induced by retrieval. Additionally, the role of NF-κB in the formation of memory extinction is now under study. Extinction entails a temporary inhibition of memory expression and entails a new memory process. Recent data support the inhibition of NF-κB in the formation of memory extinction. Here I propose the use of this transcription factor, together with other neuroplasticity-associated molecular mechanisms, as important tools for understanding the dynamics of the different phases of information processing as well as the determination of brain areas involved in such processes. Keywords: Long-term memory, consolidation, reconsolidation, extinction, gene expression, transcription factors, NF-kB, IKK, kB decoy, sulfasalazine. © 2012 Bentham Science Publishers. All rights reserved.

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Documento: Parte de libro
Título:NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction
Autor:Romano, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Depart. de Fisiología, Biología Mol. y Celular, Facultad de Ciencias Exactas y Nat., Universidad de Buenos Aires, IFIBYNE-CONICET, Ciudad Universitaria, Pab. II, 2do Piso (1428), Buenos Aires, Argentina
Palabras clave:ΚB decoy; Consolidation; Extinction; Gene expression; IKK; Long-term memory; NF-κB; Reconsolidation; Sulfasalazine; Transcription factors
Año:2012
Página de inicio:97
Página de fin:112
DOI: http://dx.doi.org/10.2174/978160805257811201010097
Título revista:Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Formation
Título revista abreviado:Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Form.
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p97_Romano

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Citas:

---------- APA ----------
(2012) . NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction. Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Formation, 97-112.
http://dx.doi.org/10.2174/978160805257811201010097
---------- CHICAGO ----------
Romano, A. "NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction" . Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Formation (2012) : 97-112.
http://dx.doi.org/10.2174/978160805257811201010097
---------- MLA ----------
Romano, A. "NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction" . Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Formation, 2012, pp. 97-112.
http://dx.doi.org/10.2174/978160805257811201010097
---------- VANCOUVER ----------
Romano, A. NF-κB transcription factor: A model for the study of transcription regulation in memory consolidation, reconsolidation and extinction. Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Form. 2012:97-112.
http://dx.doi.org/10.2174/978160805257811201010097