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Abstract:

Many viral infections are associated with the development of immunopathologies and autoimmune diseases, of difficult treatment, for which no vaccines are available yet. Obtaining compounds that conjugate both antiviral and immunomodulating activities in the same molecule would be very useful for the prevention and/or treatment of these immunopathologies of viral origin. Within this chapter, we present the evaluation of biological properties of synthetic brassinosteroids (BRs) analogs, and stigmastane and androstane derivatives, as potential antiviral and immunomodulating agents. We chose three synthetic BRs which had exhibited high antiviral activity against different human pathogenic viruses. The new steroidal molecules were designed with chemical modifications from the three BRs, in order to improve their antiviral activity. We also included some structural moieties responsible for the immunommodulating activity of well-known anti-inflammatory steroids. © 2011 Bentham Science Publishers. All rights reserved.

Registro:

Documento: Parte de libro
Título:Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs
Autor:Alche, L.E.; Michelini, F.M.
Filiación:Laboratorio de Virología: Agentes antivirales y citoprotectores, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Airesm, Ciudad Universitaria, Pabellón 2, Piso 4, C1428EGA, Buenos Aires, Argentina
Palabras clave:Conjunctival cell lines; Herpes simplex virus; Herpetic stromal keratitis; Human corneal cell line
Año:2012
Página de inicio:72
Página de fin:83
DOI: http://dx.doi.org/10.2174/978160805298111201010072
Título revista:Brassinosteroids: Practical Applications in Agriculture and Human Health
Título revista abreviado:Brassinosteroids: Pract. Appl. in Agric. and Human Health
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816080_v_n_p72_Alche

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Citas:

---------- APA ----------
Alche, L.E. & Michelini, F.M. (2012) . Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs. Brassinosteroids: Practical Applications in Agriculture and Human Health, 72-83.
http://dx.doi.org/10.2174/978160805298111201010072
---------- CHICAGO ----------
Alche, L.E., Michelini, F.M. "Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs" . Brassinosteroids: Practical Applications in Agriculture and Human Health (2012) : 72-83.
http://dx.doi.org/10.2174/978160805298111201010072
---------- MLA ----------
Alche, L.E., Michelini, F.M. "Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs" . Brassinosteroids: Practical Applications in Agriculture and Human Health, 2012, pp. 72-83.
http://dx.doi.org/10.2174/978160805298111201010072
---------- VANCOUVER ----------
Alche, L.E., Michelini, F.M. Antiherpetic and Anti-Inflammatory Activities of Novel Synthetic Brassinosteroids Analogs. Brassinosteroids: Pract. Appl. in Agric. and Human Health. 2012:72-83.
http://dx.doi.org/10.2174/978160805298111201010072