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Abstract:

Keypoints: 1.Available treatments for the management of -tinnitus are diverse. 2.Although most patients benefit from treatment to some degree a large percentage of them are left untreated and in despair with the notion that they have to learn to live with their tinnitus. 3.Currently there is no drug that is approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMEA) for the treatment of tinnitus. Thus, tinnitus is still a clinically unmet need, and most patients would welcome a drug that abolishes their phantom sound once and for all. 4.There are different forms of tinnitus which probably differ in their response to pharmacological treatment. Thus, even if a specific drug has failed to demonstrate efficacy in controlled clinical trials in a large sample, a beneficial effect in a subgroup of tinnitus patients should not be precluded. At present, most evidence-based pharmacological treatments treat specific comorbidities rather than the core of the disorder itself. 5.There is an urgent need for effective treatment approaches. Since in some individuals, tinnitus causes irritability agitation, stress, depression, insom-nia, and interferes with normal life - leading to suicidal attempts in severe cases - even a drug that produces a small but significant effect would have an enormous therapeutic impact. This review describes strategies currently available for tinnitus pharmacotherapy. © Springer Science+Business Media, LLC 2011.

Registro:

Documento: Parte de libro
Título:Pharmacological approaches to tinnitus treatment
Autor:Elgoyhen, A.B.; Langguth, B.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Buenos Aires, Argentina
Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany
Palabras clave:Hearing; Lidocaine; Neramexane; Noise trauma; Phantom sound; Tinnitus
Año:2011
Página de inicio:625
Página de fin:637
DOI: http://dx.doi.org/10.1007/978-1-60761-145-5_78
Título revista:Textbook of Tinnitus
Título revista abreviado:Textb. of Tinnitus
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816076_v_n_p625_Elgoyhen

Referencias:

  • Langguth, B., Hajak, G., Kleinjung, T., Repetitive transcranial magnetic stimulation and chronic tinnitus (2006) Acta Otolaryngol Suppl, pp. 556-565
  • Van De Heyning, P., Vermeire, K., Diebl, M., Incapacitating unilateral tinnitus in single-sided deafness treated by cochlear implantation (2008) Ann Otol Rhinol Laryngol, 117, pp. 645-652
  • Goodey, R., Tinnitus treatment: State of the art (2007) Prog Brain Res, 166, pp. 237-246
  • Dohrmann, K., Weisz, N., Schlee, W., Neurofeedback for treating tinnitus (2007) Prog Brain Res, 166, pp. 473-485
  • Jastreboff, P.J., Jastreboff, M.M., Tinnitus retraining therapy: A different view on tinnitus (2006) ORL J Otorhinolaryngol Relat Spec, 68, pp. 23-29. , discussion 9-30
  • Darlington, C.L., Smith, P.F., Drug treatments for tinnitus (2007) Prog Brain Res, 166, pp. 249-262
  • Dobie, R.A., A review of randomized clinical trials in tinnitus (1999) Laryngoscope, 109, pp. 1202-1211
  • Patterson, M.B., Balough, B.J., Review of pharmacological therapy for tinnitus (2006) Int Tinnitus J, 12, pp. 149-159
  • De Ridder, D., De Mulder, G., Menovsky, T., Electrical stimulation of auditory and somatosensory cortices for treatment of tinnitus and pain (2007) Prog Brain Res, 166, pp. 377-388
  • Vio, M.M., Holme, R.H., Hearing loss and tinnitus: 250 million people and a US$10 billion potential market (2005) Drug Discov Today, 10, pp. 1263-1265
  • Møller, A.R., Tinnitus: Presence and future (2007) Prog Brain Res, 166, pp. 3-16
  • Eggermont, J.J., Roberts, L.E., The neuroscience of tinnitus (2004) Trends Neurosci, 27, pp. 676-682
  • Eggermont, J.J., Pathophysiology of tinnitus (2007) Prog Brain Res, 166, pp. 19-35
  • Jastreboff, P.J., Phantom auditory perception (tinnitus): Mechanisms of generation and perception (1990) Neurosci Res, 8, pp. 221-254
  • Schlee, W., Hartmann, T., Langguth, B., Abnormal resting-state cortical coupling in chronic tinnitus (2009) BMC Neurosci, 10, p. 11
  • House, J.W., Brackmann, D.E., Tinnitus: Surgical treatment (1981) Ciba Found Symp, 85, pp. 204-216
  • Bauer, C.A., Turner, J.G., Caspary, D.M., Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma (2008) J Neurosci Res, 86, pp. 2564-2578
  • Kaltenbach, J.A., Godfrey, D.A., Dorsal cochlear nucleus hyperactivity and tinnitus: Are they related? (2008) Am J Audiol, 17, pp. S148-S161
  • Melcher, J.R., Sigalovsky, I.S., Guinan Jr., J.J., Lateralized tinnitus studied with functional magnetic resonance imaging: Abnormal inferior colliculus activation (2000) J Neurophysiol, 83, pp. 1058-1072
  • Weisz, N., Dohrmann, K., Elbert, T., The relevance of spontaneous activity for the coding of the tinnitus sensation (2007) Prog Brain Res, 166, pp. 61-70
  • Lambert, R.C., Bessaih, T., Leresche, N., Modulation of neuronal T-type calcium channels (2006) CNS Neurol Disord Drug Targets, 5, pp. 611-627
  • Surmeier, D.J., Ding, J., Day, M., D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons (2007) Trends Neurosci, 30, pp. 228-235
  • Wonnacott, S., Barik, J., Dickinson, J., Nicotinic receptors modulate transmitter cross talk in the CNS: Nicotinic modulation of transmitters (2006) J Mol Neurosci, 30, pp. 137-140
  • Slassi, A., Isaac, M., Edwards, L., Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications (2005) Curr Top Med Chem, 5, pp. 897-911
  • Blank, T., Nijholt, I., Kye, M.J., Small conductance Ca2+-activated K+ channels as targets of CNS drug development (2004) Curr Drug Targets CNS Neurol Disord, 3, pp. 161-167
  • Duckert, L.G., Rees, T.S., Treatment of tinnitus with intravenous lidocaine: A double-blind randomized trial (1983) Otolaryngol Head Neck Surg, 91, pp. 550-555
  • Israel, J.M., Connelly, J.S., McTigue, S.T., Lidocaine in the treatment of tinnitus aurium. A double-blind study (1982) Arch Otolaryngol, 108, pp. 471-473
  • Melding, P.S., Goodey, R.J., Thorne, P.R., The use of intravenous lignocaine in the diagnosis and treatment of tinnitus (1978) J Laryngol Otol, 92, pp. 115-121
  • Gil-Gouveia, R., Goadsby, P.J., Neuropsychiatric side-effects of lidocaine: Examples from the treatment of headache and a review (2009) Cephalalgia, 29, pp. 496-508
  • Hollmann, M.W., Durieux, M.E., Graf, B.M., Novel local anaesthetics and novel indications for local anaesthetics (2001) Curr Opin Anaesthesiol, 14, pp. 741-749
  • Trellakis, S., Lautermann, J., Lehnerdt, G., Lidocaine: Neurobiological targets and effects on the auditory system (2007) Prog Brain Res, 166, pp. 303-322
  • Grant, G.J., Barenholz, Y., Bolotin, E.M., A novel liposomal bupivacaine formulation to produce ultralongacting analgesia (2004) Anesthesiology, 101, pp. 133-137
  • Savastano, M., Lidocaine intradermal injection - A new approach in tinnitus therapy: Preliminary report (2004) Adv Ther, 21, pp. 13-20
  • Tyler, R., Coelho, C., Tao, P., Identifying tinnitus subgroups with cluster analysis (2008) Am J Audiol, 17, pp. S176-S184
  • Doyle, K.J., Bauch, C., Battista, R., Intratympanic steroid treatment: A review (2004) Otol Neurotol, 25, pp. 1034-1039
  • Slattery, W.H., Fisher, L.M., Iqbal, Z., Intratympanic steroid injection for treatment of idiopathic sudden hearing loss (2005) Otolaryngol Head Neck Surg, 133, pp. 251-259
  • Slattery, W.H., Fisher, L.M., Iqbal, Z., Oral steroid regimens for idiopathic sudden sensorineural hearing loss (2005) Otolaryngol Head Neck Surg, 132, pp. 5-10
  • Wilson, W.R., Byl, F.M., Laird, N., The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study (1980) Arch Otolaryngol, 106, pp. 772-776
  • Narozny, W., Kuczkowski, J., Kot, J., Prognostic factors in sudden sensorineural hearing loss: Our experience and a review of the literature (2006) Ann Otol Rhinol Laryngol, 115, pp. 553-558
  • Stokroos, R.J., Albers, F.W., Tenvergert, E.M., Antiviral treatment of idiopathic sudden sensorineural hearing loss: A prospective, randomized, double-blind clinical trial (1998) Acta Otolaryngol, 118, pp. 488-495
  • Westerlaken, B.O., Stokroos, R.J., Dhooge, I.J., Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy: A prospective, randomized, doubleblind clinical trial (2003) Ann Otol Rhinol Laryngol, 112, pp. 993-1000
  • Bennett, M.H., Kertesz, T., Yeung, P., Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus (2005) Cochrane Database Syst Rev, pp. CD004739
  • Lamm, K., Lamm, H., Arnold, W., Effect of hyperbaric oxygen therapy in comparison to conventional or placebo therapy or no treatment in idiopathic sudden hearing loss, acoustic trauma, noise-induced hearing loss and tinnitus. A literature survey (1998) Adv Otorhinolaryngol, 54, pp. 86-99
  • Lim, D.J., Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review (1986) Am J Otolaryngol, 7, pp. 73-99
  • Biassoni, E.C., Serra, M.R., Richtert, U., Recreational noise exposure and its effects on the hearing of adolescents. Part II: Development of hearing disorders (2005) Int J Audiol, 44, pp. 74-85
  • Holley, M.C., Keynote review: The auditory system, hearing loss and potential targets for drug development (2005) Drug Discov Today, 10, pp. 1269-1282
  • McShane, D.P., Hyde, M.L., Alberti, P.W., Tinnitus prevalence in industrial hearing loss compensation claimants (1988) Clin Otolaryngol Allied Sci, 13, pp. 323-330
  • Puel, J.L., Ruel, J., Guitton, M., The inner hair cell afferent/efferent synapses revisited: A basis for new therapeutic strategies (2002) Adv Otorhinolaryngol, 59, pp. 124-130
  • Brigande, J.V., Heller, S., Quo vadis, hair cell regeneration? (2009) Nat Neurosci, 12, pp. 679-685
  • Lynch, E.D., Kil, J., Compounds for the prevention and treatment of noise-induced hearing loss (2005) Drug Discov Today, 10, pp. 1291-1298
  • Attias, J., Weisz, G., Almog, S., Oral magnesium intake reduces permanent hearing loss induced by noise exposure (1994) Am J Otolaryngol, 15, pp. 26-32
  • Kramer, S., Dreisbach, L., Lockwood, J., Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music (2006) J Am Acad Audiol, 17, pp. 265-278
  • Kopke, R.D., Jackson, R.L., Coleman, J.K., NAC for noise: From the bench top to the clinic (2007) Hear Res, 226, pp. 114-125
  • Mico, J.A., Ardid, D., Berrocoso, E., Antidepressants and pain (2006) Trends Pharmacol Sci, 27, pp. 348-354
  • Møller, A.R., Tinnitus and pain (2007) Prog Brain Res, 166, pp. 47-53
  • Sullivan, M.D., Dobie, R.A., Sakai, C.S., Treatment of depressed tinnitus patients with nortriptyline (1989) Ann Otol Rhinol Laryngol, 98, pp. 867-872
  • Sullivan, M., Katon, W., Russo, J., A randomized trial of nortriptyline for severe chronic tinnitus (1993) Effects on Depression, Disability, and Tinnitus Symptoms. Arch Intern Med, 153, pp. 2251-2259
  • Katon, W., Sullivan, M., Russo, J., Depressive symptoms and measures of disability: A prospective study (1993) J Affect Disord, 27, pp. 245-254
  • Bayar, N., Boke, B., Turan, E., Efficacy of amitriptyline in the treatment of subjective tinnitus (2001) J Otolaryngol, 30, pp. 300-303
  • Podoshin, L., Ben-David, Y., Fradis, M., Idiopathic subjective tinnitus treated by amitriptyline hydrochloride/ biofeedback (1995) Int Tinnitus J, 1, pp. 54-60
  • Mihail, R.C., Crowley, J.M., Walden, B.E., The tricyclic trimipramine in the treatment of subjective tinnitus (1988) Ann Otol Rhinol Laryngol, 97, pp. 120-123
  • Feder, R., Tinnitus associated with amitriptyline (1990) J Clin Psychiatry, 51, pp. 85-86
  • Mendis, D., Johnston, M., An unusual case of prolonged tinnitus following low-dose amitriptyline (2008) J Psychopharmacol, 22, pp. 574-575
  • Tandon, R., Grunhaus, L., Greden, J.F., Imipramine and tinnitus (1987) J Clin Psychiatry, 48, pp. 109-111
  • Zoger, S., Svedlund, J., Holgers, K.M., The effects of sertraline on severe tinnitus suffering-A randomized, double-blind, placebo-controlled study (2006) J Clin Psychopharmacol, 26, pp. 32-39
  • Robinson, S., Antidepressants for treatment of tinnitus (2007) Prog Brain Res, 166, pp. 263-271
  • Dionne, R.A., Max, M.B., Gordon, S.M., The substance P receptor antagonist CP-99,994 reduces acute postoperative pain (1998) Clin Pharmacol Ther, 64, pp. 562-568
  • Smith, G.B., Olsen, R.W., Functional domains of GABAA receptors (1995) Trends Pharmacol Sci, 16, pp. 162-168
  • Johnson, R.M., Brummett, R., Schleuning, A., Use of alprazolam for relief of tinnitus (1993) A Double-blind Study. Arch Otolaryngol Head Neck Surg, 119, pp. 842-845
  • Kay, N.J., Oral chemotherapy in tinnitus (1981) Br J Audiol, 15, pp. 123-124
  • Gananca, M.M., Caovilla, H.H., Gananca, F.F., Clonazepam in the pharmacological treatment of vertigo and tinnitus (2002) Int Tinnitus J, 8, pp. 50-53
  • Bahmad Jr., F.M., Venosa, A.R., Oliveira, C.A., Benzodiazepines and GABAergics in treating severe disabling tinnitus of predominantly cochlear origin (2006) Int Tinnitus J, 12, pp. 140-144
  • Busto, U., Fornazzari, L., Naranjo, C.A., Protracted tinnitus after discontinuation of long-term therapeutic use of benzodiazepines (1988) J Clin Psychopharmacol, 8, pp. 359-362
  • Busto, U., Sellers, E.M., Naranjo, C.A., Withdrawal reaction after long-term therapeutic use of benzodiazepines (1986) N Engl J Med, 315, pp. 854-859
  • Ettinger, A.B., Argoff, C.E., Use of antiepileptic drugs for nonepileptic conditions: Psychiatric disorders and chronic pain (2007) Neurotherapeutics, 4, pp. 75-83
  • Neligan, A., Shorvon, S.D., The history of status epilepticus and its treatment (2009) Epilepsia, 50 (SUPPL. 3), pp. 56-68
  • Catterall, W.A., Molecular properties of brain sodium channels: An important target for anticonvulsant drugs (1999) Adv Neurol, 79, pp. 441-456
  • Willow, M., Gonoi, T., Catterall, W.A., Voltage clamp analysis of the inhibitory actions of diphenylhydantoin and carbamazepine on voltage-sensitive sodium channels in neuroblastoma cells (1985) Mol Pharmacol, 27, pp. 549-558
  • Melding, P.S., Goodey, R.J., The treatment of tinnitus with oral anticonvulsants (1979) J Laryngol Otol, 93, pp. 111-122
  • Sanchez, T.G., Balbani, A.P., Bittar, R.S., Lidocaine test in patients with tinnitus: Rationale of accomplishment and relation to the treatment with carbamazepine (1999) Auris Nasus Larynx, 26, pp. 411-417
  • Shea, J.J., Harell, M., Management of tinnitus aurium with lidocaine and carbamazepine (1978) Laryngoscope, 88, pp. 1477-1484
  • Donaldson, I., Tegretol: A double blind trial in tinnitus (1981) J Laryngol Otol, 95, pp. 947-951
  • Hulshof, J.H., Vermeij, P., The value of carbamazepine in the treatment of tinnitus (1985) ORL J Otorhinolaryngol Relat Spec, 47, pp. 262-266
  • Marks, N.J., Onisiphorou, C., Trounce, J.R., The effect of single doses of amylobarbitone sodium and carbamazepine in tinnitus (1981) J Laryngol Otol, 95, pp. 941-945
  • Levine, R.A., Typewriter tinnitus: A carbamazepineresponsive syndrome related to auditory nerve vascular compression (2006) ORL J Otorhinolaryngol Relat Spec, 68, pp. 43-46. , discussion 6-7
  • Mardini, M.K., Ear-clicking "tinnitus" responding to carbamazepine (1987) N Engl J Med, 317, p. 1542
  • Sivenius, J., Kalviainen, R., Ylinen, A., Double-blind study of Gabapentin in the treatment of partial seizures (1991) Epilepsia, 32, pp. 539-542
  • Levendoglu, F., Ogun, C.O., Ozerbil, O., Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury (2004) Spine, 29, pp. 743-751
  • Di Trapani, G., Mei, D., Marra, C., Gabapentin in the prophylaxis of migraine: A double-blind randomized placebo-controlled study (2000) Clin ter, 151, pp. 145-148
  • Bauer, C.A., Brozoski, T.J., Effect of gabapentin on the sensation and impact of tinnitus (2006) Laryngoscope, 116, pp. 675-681
  • Witsell, D.L., Hannley, M.T., Stinnet, S., Treatment of tinnitus with gabapentin: A pilot study (2007) Otol Neurotol, 28, pp. 11-15
  • Bakhshaee, M., Ghasemi, M., Azarpazhooh, M., Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: A pilot study (2008) Eur Arch Otorhinolaryngol, 265, pp. 525-530
  • Piccirillo, J.F., Finnell, J., Vlahiotis, A., Relief of idiopathic subjective tinnitus: Is gabapentin effective? (2007) Arch Otolaryngol Head Neck Surg, 133, pp. 390-397
  • Bauer, C.A., Brozoski, T.J., Gabapentin (2007) Prog Brain Res, 166, pp. 287-301
  • Hauser, W., Bernardy, K., Uceyler, N., Treatment of fibromyalgia syndrome with gabapentin and pregabalin - A meta-analysis of randomized controlled trials. Treatment of postherpetic neuralgia: Focus on pregabalin (2009) Pain, 4, pp. 17-23
  • Cappuzzo, K.A., Treatment of postherpetic neuralgia: Focus on pregabalin (2009) Clin Interv Aging, 4, pp. 17-23
  • Montgomery, S.A., Herman, B.K., Schweizer, E., The efficacy of pregabalin and benzodiazepines in generalized anxiety disorder presenting with high levels of insomnia (2009) Int Clin Psychopharmacol, 24, pp. 214-222
  • Russell, I.J., Crofford, L.J., Leon, T., The effects of pregabalin on sleep disturbance symptoms among individuals with fibromyalgia syndrome (2009) Sleep Med, 10, pp. 604-610
  • Simpson, J.J., Gilbert, A.M., Weiner, G.M., The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus (1999) Am J Otol, 20, pp. 627-631
  • Mansbach, A.L., Freyens, P., Tinnitus: Current data and treatment with sodium valproate (1983) Acta Otorhinolaryngol Belg, 37, pp. 697-705
  • Menkes, D.B., Larson, P.M., Sodium valproate for tinnitus (1998) J Neurol Neurosurg Psychiatry, 65, p. 803
  • Guitton, M.J., Wang, J., Puel, J.L., New pharmacological strategies to restore hearing and treat tinnitus (2004) Acta Otolaryngol, 124, pp. 411-415
  • Azevedo, A.A., Figueiredo, R.R., Treatment of tinnitus with acamprosate (2007) Prog Brain Res, 166, pp. 273-277
  • Denk, D.M., Heinzl, H., Franz, P., Caroverine in tinnitus treatment. A placebo-controlled blind study (1997) Acta Otolaryngol, 117, pp. 825-830
  • Domeisen, H., Hotz, M.A., Hausler, R., Caroverine in tinnitus treatment (1998) Acta Otolaryngol, 118, pp. 606-608
  • Figueiredo, R.R., Langguth, B., Mello De Oliveira, P., Tinnitus treatment with memantine (2008) Otolaryngol Head Neck Surg, 138, pp. 492-496
  • Danysz, W., Parsons, C.G., Jirgensons, A., Aminoalkyl-cyclohexanes as a novel class of uncompetitive NMDA receptor antagonists (2002) Curr Pharm des, 8, pp. 835-843
  • Plazas, P.V., Savino, J., Kracun, S., Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors (2007) Eur J Pharmacol, 566, pp. 11-19
  • Lockwood, A.H., Salvi, R.J., Coad, M.L., The functional neuroanatomy of tinnitus: Evidence for limbic system links and neural plasticity (1998) Neurology, 50, pp. 114-120
  • Jastreboff, P.J., Hazell, J.W., A neurophysiological approach to tinnitus: Clinical implications (1993) Br J Audiol, 27, pp. 7-17
  • Lopez-Gonzalez, M.A., Moliner-Peiro, F., Alfaro-Garcia, J., Sulpiride plus hydroxyzine decrease tinnitus perception (2007) Auris Nasus Larynx, 34, pp. 23-27
  • Lopez-Gonzalez, M.A., Santiago, A.M., Esteban-Ortega, F., Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway (2007) J Otolaryngol, 36, pp. 213-219
  • Azevedo, A., Langguth, B., De Oliveira, P., Tinnitus treatment with piribedil guided by electrocochleography and acoustic otoemisions (2009) Otology and Neurotology, 30, pp. 676-680
  • Reimold, M., Solbach, C., Noda, S., Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol (2007) Psychopharmacology (Berl), 190, pp. 241-249
  • Sniderman, A., Targets for LDL-lowering therapy (2009) Curr Opin Lipidol, 20, pp. 282-287
  • Olzowy, B., Canis, M., Hempel, J.M., Effect of atorvastatin on progression of sensorineural hearing loss and tinnitus in the elderly: Results of a prospective, randomized, double-blind clinical trial (2007) Otol Neurotol, 28, pp. 455-458
  • Timmerman, H., Calcium modulation and clinical effect (1987) Profile of Cyclandelate. Drugs, 33 (SUPPL. 2), pp. 1-4
  • Memin, Y., Perceived efficacy of cyclandelate in the treatment of cochleovestibular and retinal disturbances related to cerebrovascular insufficiency. A study in general practice comprising 2772 patients (1987) Drugs, 33 (SUPPL. 2), pp. 120-124
  • Hester, T.O., Theilman, G., Green, W., Cyclandelate in the management of tinnitus: A randomized, placebocontrolled study (1998) Otolaryngol Head Neck Surg, 118, pp. 329-332
  • Hutcheon, D., Vincent, M.E., Sandhu, R.S., Clinical use of diuretics in congestive heart failure (1981) J Clin Pharmacol, 21, pp. 668-672
  • Rybak, L.P., Morizono, T., Effect of furosemide upon endolymph potassium concentration (1982) Hear Res, 7, pp. 223-231
  • Risey, J.A., Guth, P.S., Amedee, R.G., Furosemide distinguishes central and peripheral tinnitus (1995) Int Tinnitus J, 1, pp. 99-103
  • Futaki, T., Kitahara, M., Morimoto, M., A comparison of the furosemide and glycerol tests for Meniere's disease. with special reference to the bilateral lesion (1977) Acta Otolaryngol, 83, pp. 272-278
  • Kuchar, D.L., O'Rourke, M.F., High dose furosemide in refractory cardiac failure (1985) Eur Heart J, 6, pp. 954-958
  • Mahadevan, S., Park, Y., Multifaceted therapeutic benefits of Ginkgo biloba L.: Chemistry, efficacy, safety, and uses (2008) J Food Sci, 73, pp. R14-R19
  • Holstein, N., Ginkgo extract helps patients suffering from tinnitus. Review of the literature shows: Tinnitus decreases (2000) MMW Fortschr Med, 142, p. 46
  • Morgenstern, C., Biermann, E., The efficacy of Ginkgo special extract EGb 761 in patients with tinnitus (2002) Int J Clin Pharmacol Ther, 40, pp. 188-197
  • Drew, S., Davies, E., Effectiveness of Ginkgo biloba in treating tinnitus: Double blind, placebo controlled trial (2001) Br Med J, 322, p. 73
  • Rejali, D., Sivakumar, A., Balaji, N., Ginkgo biloba does not benefit patients with tinnitus: A randomized placebo-controlled double-blind trial and meta-analysis of randomized trials (2004) Clin Otolaryngol Allied Sci, 29, pp. 226-231
  • Enrico, P., Sirca, D., Mereu, M., Antioxidants, minerals, vitamins, and herbal remedies in tinnitus therapy (2007) Prog Brain Res, 166, pp. 323-330
  • Srinivasan, V., Pandi-Perumal, S.R., Trahkt, I., Melatonin and melatonergic drugs on sleep: Possible mechanisms of action (2009) Int J Neurosci, 119, pp. 821-846
  • Megwalu, U.C., Finnell, J.E., Piccirillo, J.F., The effects of melatonin on tinnitus and sleep (2006) Otolaryngol Head Neck Surg, 134, pp. 210-213
  • Rosenberg, S.I., Silverstein, H., Rowan, P.T., Effect of melatonin on tinnitus (1998) Laryngoscope, 108, pp. 305-310
  • Lazzaroni, M., Porro, G.B., Management of NSAIDinduced gastrointestinal toxicity: Focus on proton pump inhibitors (2009) Drugs, 69, pp. 51-69
  • Briner, W., House, J., O'Leary, M., Synthetic prostaglandin E1 misoprostol as a treatment for tinnitus (1993) Arch Otolaryngol Head Neck Surg, 119, pp. 652-654
  • Yilmaz, I., Akkuzu, B., Cakmak, O., Misoprostol in the treatment of tinnitus: A double-blind study (2004) Otolaryngol Head Neck Surg, 130, pp. 604-610
  • Akkuzu, B., Yilmaz, I., Cakmak, O., Efficacy of misoprostol in the treatment of tinnitus in patients with diabetes and/or hypertension (2004) Auris Nasus Larynx, 31, pp. 226-232
  • Scriabine, A., Kerckhoff Den W.Van, Pharmacology of nimodipine. A review (1988) Ann N y Acad Sci, 522, pp. 698-706
  • Theopold, H.M., Nimodipine (Bay e 9736) a new therapy concept in diseases of the inner ear? (1985) Laryngol Rhinol Otol (Stuttg), 64, pp. 609-613
  • Davies, E., Knox, E., Donaldson, I., The usefulness of nimodipine, an L-calcium channel antagonist, in the treatment of tinnitus (1994) Br J Audiol, 28, pp. 125-129
  • Mazurek, B., Haupt, H., Szczepek, A.J., Evaluation of vardenafil for the treatment of subjective tinnitus: A controlled pilot study (2009) J Negat Results Biomed, 8, p. 3
  • Choi, D.W., Koh, J.Y., Zinc and brain injury (1998) Annu Rev Neurosci, 21, pp. 347-375
  • Shambaugh Jr., G.E., Zinc for tinnitus, imbalance, and hearing loss in the elderly (1986) Am J Otol, 7, pp. 476-477
  • Coelho, C.B., Tyler, R., Hansen, M., Zinc as a possible treatment for tinnitus (2007) Prog Brain Res, 166, pp. 279-285
  • Ochi, K., Kinoshita, H., Kenmochi, M., Zinc deficiency and tinnitus (2003) Auris Nasus Larynx, 30 (SUPPL.), pp. S25-S28
  • Yetiser, S., Tosun, F., Satar, B., The role of zinc in management of tinnitus (2002) Auris Nasus Larynx, 29, pp. 329-333
  • Paaske, P.B., Pedersen, C.B., Kjems, G., Zinc in the management of tinnitus (1991) Placebo-controlled Trial. Ann Otol Rhinol Laryngol, 100, pp. 647-649
  • Arda, H.N., Tuncel, U., Akdogan, O., The role of zinc in the treatment of tinnitus (2003) Otol Neurotol, 24, pp. 86-89

Citas:

---------- APA ----------
Elgoyhen, A.B. & Langguth, B. (2011) . Pharmacological approaches to tinnitus treatment. Textbook of Tinnitus, 625-637.
http://dx.doi.org/10.1007/978-1-60761-145-5_78
---------- CHICAGO ----------
Elgoyhen, A.B., Langguth, B. "Pharmacological approaches to tinnitus treatment" . Textbook of Tinnitus (2011) : 625-637.
http://dx.doi.org/10.1007/978-1-60761-145-5_78
---------- MLA ----------
Elgoyhen, A.B., Langguth, B. "Pharmacological approaches to tinnitus treatment" . Textbook of Tinnitus, 2011, pp. 625-637.
http://dx.doi.org/10.1007/978-1-60761-145-5_78
---------- VANCOUVER ----------
Elgoyhen, A.B., Langguth, B. Pharmacological approaches to tinnitus treatment. Textb. of Tinnitus. 2011:625-637.
http://dx.doi.org/10.1007/978-1-60761-145-5_78