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Abstract:

Keypoints: 1. One in 10 adults has subjective tinnitus, and for 1 in 100 adults, tinnitus severely affects their quality of life. 2. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. 3. Since in some individuals, tinnitus causes irritability, agitation, stress, depression, insomnia, and interferes with normal life, even a drug that produces a small but significant effect would have a huge therapeutic impact. 4. A glimpse of hope is appearing in the near future, as some pharmaceutical industries now have compounds targeting tinnitus in their pipeline. 5. If these compounds finally reach the market, they will set a new era that will revolutionize the treatment of tinnitus. © Springer Science+Business Media, LLC 2011.

Registro:

Documento: Parte de libro
Título:The pharmacologist
Autor:Elgoyhen, A.B.; Rothlin, C.V.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires 1428, Argentina
Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina
School of Medicine, Yale University, 300 Cedar St TAC S625A, New Haven, CT, 06520, United States
Palabras clave:Animal models; Drug discovery; Lead compounds; Phantom sound; Tinnitus
Año:2011
Página de inicio:251
Página de fin:257
DOI: http://dx.doi.org/10.1007/978-1-60761-145-5_30
Título revista:Textbook of Tinnitus
Título revista abreviado:Textb. of Tinnitus
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97816076_v_n_p251_Elgoyhen

Referencias:

  • Eggermont, J.J., Pathophysiology of tinnitus (2007) Prog Brain Res, 166, pp. 19-35
  • Eggermont, J.J., Role of auditory cortex in noise- and drug-induced tinnitus (2008) Am J Audiol, 17, pp. S162-S169
  • Kaltenbach, J.A., Godfrey, D.A., Dorsal cochlear nucleus hyperactivity and tinnitus: Are they related? (2008) Am J Audiol, 17, pp. S148-S161
  • Bauer, C.A., Turner, J.G., Caspary, D.M., Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma (2008) J Neurosci Res, 86, pp. 2564-2578
  • Lanting, C.P., De Kleine, E., Bartels, H., Functional imaging of unilateral tinnitus using fMRI (2008) Acta Otolaryngol, 128, pp. 415-421
  • Reyes, S.A., Salvi, R.J., Burkard, R.F., Brain imaging of the effects of lidocaine on tinnitus (2002) Hear Res, 171, pp. 43-50
  • Melcher, J.R., Sigalovsky, I.S., Guinan Jr., J.J., Lateralized tinnitus studied with functional magnetic resonance imaging: Abnormal inferior colliculus activation (2000) J Neurophysiol, 83, pp. 1058-1072
  • Schlee, W., Hartmann, T., Langguth, B., Abnormal resting-state cortical coupling in chronic tinnitus (2009) BMC Neurosci, 10, p. 11
  • Smits, M., Kovacs, S., De Ridder, D., Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus (2007) Neuroradiology, 49, pp. 669-679
  • Lambert, R.C., Bessaih, T., Leresche, N., Modulation of neuronal T-type calcium channels (2006) CNS Neurol Disord Drug Targets, 5, pp. 611-627
  • Surmeier, D.J., Ding, J., Day, M., D1 and D2 dopaminereceptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons (2007) Trends Neurosci, 30, pp. 228-235
  • Wonnacott, S., Barik, J., Dickinson, J., Nicotinic receptors modulate transmitter cross talk in the CNS: Nicotinic modulation of transmitters (2006) J Mol Neurosci, 30, pp. 137-140
  • Slassi, A., Isaac, M., Edwards, L., Recent advances in non-competitive mGlu5 receptor antagonists and their potential therapeutic applications (2005) Curr Top Med Chem, 5, pp. 897-911
  • Blank, T., Nijholt, I., Kye, M.J., Small conductance Ca2 + -activated K + channels as targets of CNS drug development (2004) Curr Drug Targets CNS Neurol Disord, 3, pp. 161-167
  • Muroi, Y., Chanda, B., Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel (2009) J Gen Physiol, 133, pp. 1-15
  • Duckert, L.G., Rees, T.S., Treatment of tinnitus with intravenous lidocaine: A double-blind randomized trial (1983) Otolaryngol Head Neck Surg, 91, pp. 550-555
  • Israel, J.M., Connelly, J.S., McTigue, S.T., Lidocaine in the treatment of tinnitus aurium. A double-blind study (1982) Arch Otolaryngol, 108, pp. 471-473
  • Kalcioglu, M.T., Bayindir, T., Erdem, T., Objective evaluation of the effects of intravenous lidocaine on tinnitus (2005) Hear Res, 199, pp. 81-88
  • Lenarz, T., Treatment of tinnitus with lidocaine and tocainide (1986) Scand Audiol Suppl, 26, pp. 49-51
  • Melding, P.S., Goodey, R.J., Thorne, P.R., The use of intravenous lignocaine in the diagnosis and treatment of tinnitus (1978) J Laryngol Otol, 92, pp. 115-121
  • Merchant, S.N., Merchant, N., Intravenous lignocaine in tinnitus (1985) J Postgrad Med, 31, pp. 80-82
  • Trellakis, S., Lautermann, J., Lehnerdt, G., Lidocaine: Neurobiological targets and effects on the auditory system (2007) Prog Brain Res, 166, pp. 303-322
  • Darlington, C.L., Smith, P.F., Drug treatments for tinnitus (2007) Prog Brain Res, 166, pp. 249-262
  • Patterson, M.B., Balough, B.J., Review of pharmacological therapy for tinnitus (2006) Int Tinnitus J, 12, pp. 149-159
  • Møller, A.R., Tinnitus: Presence and future (2007) Prog Brain Res, 166, pp. 3-16
  • Levine, R.A., Typewriter tinnitus: A carbamazepineresponsive syndrome related to auditory nerve vascular compression (2006) ORL J Otorhinolaryngol Relat Spec, 68, pp. 43-46. , discussion 6-7
  • Mardini, M.K., Ear-clicking "tinnitus" responding to carbamazepine (1987) N Engl J Med, 317, p. 1542
  • Tyler, R., Coelho, C., Tao, P., Identifying tinnitus subgroups with cluster analysis (2008) Am J Audiol, 17, pp. S176-S184
  • Eggermont, J.J., Tinnitus: Neurobiological substrates (2005) Drug Discov Today, 10, pp. 1283-1290
  • Enna, S.J., Williams, M., Challenges in the search for drugs to treat central nervous system disorders (2009) J Pharmacol Exp Ther, 329, pp. 404-411
  • Spedding, M., Jay, T., Costa E Silva, J., A pathophysiological paradigm for the therapy of psychiatric disease (2005) Nat Rev Drug Discov, 4, pp. 467-476
  • Henry, T.R., The history of valproate in clinical neuroscience (2003) Psychopharmacol Bull, 37 (SUPPL. 2), pp. 5-16
  • Carpenter, W.T., Koenig, J.I., The evolution of drug development in schizophrenia: Past issues and future opportunities (2008) Neuropsychopharmacology, 33, pp. 2061-2079
  • Johannessen Landmark, C., Antiepileptic drugs in nonepilepsy disorders: Relations between mechanisms of action and clinical efficacy (2008) CNS Drugs, 22, pp. 27-47
  • Bauer, C.A., Animal models of tinnitus (2003) Otolaryngol Clin North Am, 36, pp. 267-285
  • Jastreboff, P.J., Brennan, J.F., Evaluating the loudness of phantom auditory perception (tinnitus) in rats (1994) Audiology, 33, pp. 202-217
  • Turner, J.G., Behavioral measures of tinnitus in laboratory animals (2007) Prog Brain Res, 166, pp. 147-156
  • De Ridder, D., Fransen, H., Francois, O., Amygdalohippocampal involvement in tinnitus and auditory memory (2006) Acta Otolaryngol Suppl, 556, pp. 50-53
  • Jastreboff, P.J., Jastreboff, M.M., Tinnitus retraining therapy: A different view on tinnitus (2006) ORL J Otorhinolaryngol Relat Spec, 68, pp. 23-29. , discussion 9-30
  • Bauer, C.A., Mechanisms of tinnitus generation (2004) Curr Opin Otolaryngol Head Neck Surg, 12, pp. 413-417
  • Hurko, O., Ryan, J.L., Translational research in central nervous system drug discovery (2005) NeuroRx, 2, pp. 671-682
  • Frankenburg, F.R., Baldessarini, R.J., Neurosyphilis, malaria, and the discovery of antipsychotic agents (2008) Harv Rev Psychiatry, 16, pp. 299-307
  • Langguth, B., Goodey, R., Azevedo, A., Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006 (2007) Prog Brain Res, 166, pp. 525-536
  • Vio, M.M., Holme, R.H., Hearing loss and tinnitus: 250 million people and a US$10 billion potential market (2005) Drug Discov Today, 10, pp. 1263-1265
  • Plazas, P.V., Savino, J., Kracun, S., Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors (2007) Eur J Pharmacol, 566, pp. 11-19
  • Brocco, M., Dekeyne, A., Mannoury La Cour, C., Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents (2008) Eur Neuropsychopharmacol, 18, pp. 729-750
  • Eggermont, J.J., Komiya, H., Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood (2000) Hear Res, 142, pp. 89-101
  • Norena, A.J., Eggermont, J.J., Changes in spontaneous neural activity immediately after an acoustic trauma: Implications for neural correlates of tinnitus (2003) Hear Res, 183, pp. 137-153
  • Norena, A.J., Tomita, M., Eggermont, J.J., Neural changes in cat auditory cortex after a transient pure-tone trauma (2003) J Neurophysiol, 90, pp. 2387-2401
  • Muhlnickel, W., Elbert, T., Taub, E., Reorganization of auditory cortex in tinnitus (1998) Proc Natl Acad Sci USA, 95, pp. 10340-10343
  • Norena, A.J., Eggermont, J.J., Enriched acoustic environment after noise trauma reduces hearing loss and prevents cortical map reorganization (2005) J Neurosci, 25, pp. 699-705
  • Norena, A.J., Eggermont, J.J., Enriched acoustic environment after noise trauma abolishes neural signs of tinnitus (2006) Neuroreport, 17, pp. 559-563
  • Stark, H., Scheich, H., Dopaminergic and serotonergic neurotransmission systems are differentially involved in auditory cortex learning: A long-term microdialysis study of metabolites (1997) J Neurochem, 68, pp. 691-697
  • Bao, S., Chan, V.T., Merzenich, M.M., Cortical remodelling induced by activity of ventral tegmental dopamine neurons (2001) Nature, 412, pp. 79-83
  • Kilgard, M.P., Merzenich, M.M., Cortical map reorganization enabled by nucleus basalis activity (1998) Science, 279, pp. 1714-1718
  • Gritti, I., Mainville, L., Jones, B.E., Codistribution of GABA- with acetylcholine-synthesizing neurons in the basal forebrain of the rat (1993) J Comp Neurol, 329, pp. 438-457
  • Gritti, I., Mainville, L., Mancia, M., GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat (1997) J Comp Neurol, 383, pp. 163-177
  • Seki, S., Eggermont, J.J., Changes in spontaneous firing rate and neural synchrony in cat primary auditory cortex after localized tone-induced hearing loss (2003) Hear Res, 180, pp. 28-38
  • Lobarinas, E., Dalby-Brown, W., Stolzberg, D., (2009) Effects of the BK Agonists BMS-204352 and the Enantiomeric Compound ("R-Enantiomer") on Transient, Salicylate Induced Tinnitus in Rats, , Association for Research in Otolarygol Baltimore, MD
  • Nardi, A., Olesen, S.P., BK channel modulators: A comprehensive overview (2008) Curr Med Chem, 15, pp. 1126-1146
  • Korsgaard, M.P., Hartz, B.P., Brown, W.D., Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels (2005) J Pharmacol Exp Ther, 314, pp. 282-292
  • De Lafuente, V., Romo, R., Neuronal correlates of subjective sensory experience (2005) Nat Neurosci, 8, pp. 1698-1703
  • De Lafuente, V., Romo, R., Neural correlate of subjective sensory experience gradually builds up across cortical areas (2006) Proc Natl Acad Sci U S A, 103, pp. 14266-14271

Citas:

---------- APA ----------
Elgoyhen, A.B. & Rothlin, C.V. (2011) . The pharmacologist. Textbook of Tinnitus, 251-257.
http://dx.doi.org/10.1007/978-1-60761-145-5_30
---------- CHICAGO ----------
Elgoyhen, A.B., Rothlin, C.V. "The pharmacologist" . Textbook of Tinnitus (2011) : 251-257.
http://dx.doi.org/10.1007/978-1-60761-145-5_30
---------- MLA ----------
Elgoyhen, A.B., Rothlin, C.V. "The pharmacologist" . Textbook of Tinnitus, 2011, pp. 251-257.
http://dx.doi.org/10.1007/978-1-60761-145-5_30
---------- VANCOUVER ----------
Elgoyhen, A.B., Rothlin, C.V. The pharmacologist. Textb. of Tinnitus. 2011:251-257.
http://dx.doi.org/10.1007/978-1-60761-145-5_30