A numerical simulation of the growth of a multicellular spheroid was made. First, we took into account the model of Sherratt & Chaplain formulated in terms of cellular densities. Afterwards, we incorporated to the model the contributions of Tan & Ang, who added a random term to the nutrient concentration and a delay factor to the main equations of the model due to the release of cytostatic and cytotoxic factors from the necrotic core of the tumor. Lastly, we proposed a new delay model that led to a more suitable representation of the physiopathological phenomena in so far as the simulation shows the deceleration in the tumor growth and the decrease of proliferative cell density over time, as a consequence of the presence of the aforementioned cytostatic and cytotoxic factors. © 2016 IEEE.
Documento: | Conferencia |
Título: | Simulación numérica del crecimiento de un tumor avascular |
Autor: | Weiman, M.; Vignetta, E.; Maiza, I.Z. |
Filiación: | Facultad de Ingeniería y Ciencias Exactas y Naturales, Universidad Favaloro, Tte. Gral. Juan Domingo Perón 3175, Buenos Aires, Argentina |
Año: | 2016 |
DOI: | http://dx.doi.org/10.1109/ARGENCON.2016.7585329 |
Título revista: | 2016 IEEE Biennial Congress of Argentina, ARGENCON 2016 |
Título revista abreviado: | IEEE Bienn. Congr. Argent., ARGENCON |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814673_v_n_p_Weiman |