Abstract:
Pore formation in lipid bilayers subjected to a transverse electric field is studied by means of Molecular Dynamics simulations of 1,2-dipalmitoyl-sn- glycero-3-phosphatidylcholine (DOPC). The physical characteristics of the lipid membrane are crucial to understand the electroporation conditions. For example, addition of cholesterol (Chol) causes a substantial increment of membrane cohesion that results in an increase of the minimum electric field needed for membrane permeabilization. Instead, dimethyl sulfoxide (DMSO) is known to produce an opposite effect on membrane properties by increasing its fluidity and disorder that may open the possibility to facilitate the membrane electroporation process. © 2011 IEEE.
Registro:
| Documento: |
Conferencia
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| Título: | Structure and electroporation of lipid bilayers: A molecular dynamics study |
| Autor: | Reigada, R.; Fernandez, M.L. |
| Ciudad: | Istanbul |
| Filiación: | Departament de Química Física, Universitat de Barcelona, c/Martí i Franqués 1, Pta 4, 08028 Barcelona, Spain
Laboratorio de Sistemas Complejos, Departamento de Computación, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
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| Palabras clave: | Electroporation; Lipid membranes; Membrane electroporation; Membrane permeabilization; Membrane properties; Molecular dynamics simulations; Physical characteristics; Pore formation; Transverse electric field; Dimethyl sulfoxide; Dynamics; Electric fields; Membranes; Molecular dynamics; Organic solvents; Lipid bilayers |
| Año: | 2011
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| DOI: |
http://dx.doi.org/10.1109/URSIGASS.2011.6051307 |
| Título revista: | 2011 30th URSI General Assembly and Scientific Symposium, URSIGASS 2011
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| Título revista abreviado: | URSI Gen. Assem. Sci. Symp., URSIGASS
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| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814244_v_n_p_Reigada |
Referencias:
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- Belehradek, M., Domenge, C., Luboinski, B., Orlowski, S., Belehradek, J., Mir, L.L.M., Electrochemotherapy, a new antitumor treatment (1993) Cancer, 72, pp. 3694-3700
- Tieleman, D.P., The molecular basis of electroporation (2004) BMC Biochemistry, 5, p. 10
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- Fernández, M.L., Marshall, G., Sagués, F., Reigada, R., Structural and kinetic molecular dynamics study of electroporation in cholesterol-containing bilayers (2010) J. Phys. Chem. B, 114, pp. 6855-6865
- Gurtovenko, A.A., Anwar, J., Modulating the structure and properties of cell membranes: The molecular mechanism of action of dimethyl sulfoxide (2007) Journal of Physical Chemistry B, 111 (35), pp. 10453-10460. , DOI 10.1021/jp073113e
- Lindahl, E., Hess, B., Van Der Spoel, D., GROMACS 3.0: A package for molecular simulation and trajectory analysis (2001) Journal of Molecular Modeling, 7 (8), pp. 306-317. , http://link.springer.de/link/service/journals/00894/contents/01/00045/ paper/s008940100045ch110.html, DOI 10.1007/S008940100045
Citas:
---------- APA ----------
Reigada, R. & Fernandez, M.L.
(2011)
. Structure and electroporation of lipid bilayers: A molecular dynamics study. 2011 30th URSI General Assembly and Scientific Symposium, URSIGASS 2011.
http://dx.doi.org/10.1109/URSIGASS.2011.6051307---------- CHICAGO ----------
Reigada, R., Fernandez, M.L.
"Structure and electroporation of lipid bilayers: A molecular dynamics study"
. 2011 30th URSI General Assembly and Scientific Symposium, URSIGASS 2011
(2011).
http://dx.doi.org/10.1109/URSIGASS.2011.6051307---------- MLA ----------
Reigada, R., Fernandez, M.L.
"Structure and electroporation of lipid bilayers: A molecular dynamics study"
. 2011 30th URSI General Assembly and Scientific Symposium, URSIGASS 2011, 2011.
http://dx.doi.org/10.1109/URSIGASS.2011.6051307---------- VANCOUVER ----------
Reigada, R., Fernandez, M.L. Structure and electroporation of lipid bilayers: A molecular dynamics study. URSI Gen. Assem. Sci. Symp., URSIGASS. 2011.
http://dx.doi.org/10.1109/URSIGASS.2011.6051307