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Doctorovich, F.; Bikiel, D.E.; Pellegrino, J.; Suárez, S.A.; Martí, M.A. "How to Find an HNO Needle in a (Bio)-Chemical Haystack" (2014) Progress in Inorganic Chemistry. 58:145-184
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Abstract:

Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainly on hydroxylamine and its derivatives, NONOates, and C-nitroso compounds. HNO releasing agents have interesting perspectives as potential therapeutic compounds. However, more work, where HNO detections methods are critical, is needed to understand the chemical mechanisms underlying the observed physiological effects. Quantification of HNO is challenging because it is a very reactive species with a high rate for dimerization. Two different methodologies, trapping and real-time detection methods, have been explored in order to quantify HNO. The chapter reviews the recent advances in both types of azanone detection methods. © 2014 by John Wiley & Sons, Inc. All rights reserved.

Registro:

Documento: Parte de libro
Título:How to Find an HNO Needle in a (Bio)-Chemical Haystack
Autor:Doctorovich, F.; Bikiel, D.E.; Pellegrino, J.; Suárez, S.A.; Martí, M.A.
Filiación:INQUIMAE-CONICET, DQIAQF, Universidad de Buenos Aires, Argentina
Palabras clave:Azanone; Biochemical reactions; Chemical reactions; HNO releasing agents; Real-time detection method; Therapeutic compounds; Trapping method; Amines; Chemical reactions; Reaction kinetics; Signal detection; Azanone; Biochemical reactions; Real-time detection; Releasing agent; Therapeutic compounds; Trapping methods; Chemical detection
Año:2014
Volumen:58
Página de inicio:145
Página de fin:184
DOI: http://dx.doi.org/10.1002/9781118792797.ch02
Título revista:Progress in Inorganic Chemistry
Título revista abreviado:Prog. in Inorg. Chem.
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97811187_v58_n_p145_Doctorovich

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Citas:

---------- APA ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A. & Martí, M.A. (2014) . How to Find an HNO Needle in a (Bio)-Chemical Haystack. Progress in Inorganic Chemistry, 58, 145-184.
http://dx.doi.org/10.1002/9781118792797.ch02
---------- CHICAGO ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A. "How to Find an HNO Needle in a (Bio)-Chemical Haystack" . Progress in Inorganic Chemistry 58 (2014) : 145-184.
http://dx.doi.org/10.1002/9781118792797.ch02
---------- MLA ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A. "How to Find an HNO Needle in a (Bio)-Chemical Haystack" . Progress in Inorganic Chemistry, vol. 58, 2014, pp. 145-184.
http://dx.doi.org/10.1002/9781118792797.ch02
---------- VANCOUVER ----------
Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A. How to Find an HNO Needle in a (Bio)-Chemical Haystack. Prog. in Inorg. Chem. 2014;58:145-184.
http://dx.doi.org/10.1002/9781118792797.ch02