â-Cyclodextrins ( â - CDs), macrocyclic oligosaccharides formed by seven glucopyranose units, have a rigid lipophilic cavity and can form host - guest inclusion complexes with suitably sized hydrophobic molecules. Water content infl uences the structure of â - CDs and affects the chemical and physical stability of complexed compounds. This work investigated the relationship between the sorption characteristics of â - CDs and complexes formed with thymol and cinnamaldehyde and their release. The complexes were obtained by coprecipitation, fi ltered, freeze - dried, and stored at constant relative humidity (RH) in evacuated chambers (22% - 97%) at 25 ° C. The release of encapsulated compounds was determined after equilibration by differential scanning calorimetry (DSC) following the enthalpy of the fusion peak at 50 ° C (thymol) and 7.5 ° C (cinnamaldehyde). DSC thermograms of complexes after freeze drying showed the disappearance of fusion peaks of thymol and cinnamaldehyde, indicating complex formation. Water - sorption isotherms for â - CD and the complexes showed constant and low water sorption at an RH of less than 80%, and then the uptake of water increased abruptly. At 95% RH, the water adsorbed was in the order â - CD (12.5 mol water/mol â - CD) â - CD - thymol (8.5 mol water/mol complex) â - CD - cinnamaldehyde (7 mol water/mol complex). The guest molecules displaced water molecules from inside the cavity of â - CD. At an RH of less than 84%, thymol and cinnamaldehyde were not released. The percent of released compound abruptly increased from 84% RH, coinciding with the abrupt increase of water. Water sorption signifi cantly affected thymol and cinnamaldehyde complexes with â - CD, and complex stability was thus governed by the shape of the water -sorption isotherm. © 2010 Blackwell Publishing.
Documento: | Parte de libro |
Título: | Water-Sorption Properties and Stability of Inclusion Complexes of Thymol and Cinnamaldehyde with β-Cyclodextrins |
Autor: | Ponce, P.A.; Buera, M.P.; Elizalde, B.E. |
Filiación: | Departamento de Industias, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Departamentos de Industrias y de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
Palabras clave: | β-Cyclodextrins - rigid lipophilic cavity; cyclodextrins (CDs) - cyclic oligosaccharides consisting of glucose units; DSC thermograms of complexes - disappearance of fusion peaks of thymol and cinnamaldehyde; Inclusion complexes of thymol and cinnamaldehyde - coprecipitation method; Sorption isotherms - standard isopiestic static-gravimetric method; Water sorption - affecting stability; Water-sorption properties - stability of inclusion complexes |
Año: | 2010 |
Página de inicio: | 149 |
Página de fin: | 156 |
DOI: | http://dx.doi.org/10.1002/9780470958193.ch10 |
Título revista: | Water Properties in Food, Health, Pharmaceutical and Biological Systems: ISOPOW 10 |
Título revista abreviado: | Water Prop. in Food, Health, Pharmaceutical and Biol. Syst.: ISOPOW 10 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97808138_v_n_p149_Ponce |