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Abstract:

Polyvinyl alcohol (PVA) porous carriers were prepared by means of ice templating of aqueous solutions containing of 90 kD and/or 16 kD PVA. The carriers were loaded with traces of a colored probe (methyl orange) to screen their release properties, once immersed in water. The carriers prepared from solutions containing 90 kD and 16 kD PVA resulted in intimate polymer mixtures, exhibiting physical properties that stand in between those of the bare 90 kD or 16 kD PVA end members. The freezing protocols employed were adapted to prepare carriers textured in the form of either monolithic scaffolds (directional constant freezing rate) or millimetric pellets (flash-freeze). Monolithic carriers remain stable in aqueous solution, and the probe release is governed by a swelling-diffusion mechanism. The kinetics of probe release can be tuned from minutes to hours by either increasing the total PVA content or the 90 kD-to-16 kD PVA ratio in the parent solution. In contrast, pellets (millimetric carriers) immersed in water release the probe on the scale of minutes, irrespective of the PVA content or composition. However, the PVA content and the 90 kD-to-16 kD PVA ratio dramatically affect the stability of the carriers. Depending on the formulation, these small carriers can develop swelling, erosion, or eventually massive dissolution. © 2018 American Chemical Society.

Registro:

Documento: Artículo
Título:Highly Structured Polyvinyl Alcohol Porous Carriers: Tuning Inherent Stability and Release Kinetics in Water
Autor:Sonego, J.M.; Flórez-Castillo, J.M.; Jobbágy, M.
Filiación:Instituto de Química Física de Materiales, Medio Ambiente y Energía INQUIMAE, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2 (C1428EHA), Buenos Aires, Argentina
Grupo de Investigación en Bioquímica y Microbiología - GIBIM, Universidad Industrial de Santander, Carrera 27 Calle 9, Bucaramanga, Santander, 680002, Colombia
Año:2018
Volumen:3
Número:2
Página de inicio:2390
Página de fin:2395
DOI: http://dx.doi.org/10.1021/acsomega.7b01961
Título revista:ACS Omega
Título revista abreviado:ACS Omega
ISSN:24701343
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_24701343_v3_n2_p2390_Sonego

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Citas:

---------- APA ----------
Sonego, J.M., Flórez-Castillo, J.M. & Jobbágy, M. (2018) . Highly Structured Polyvinyl Alcohol Porous Carriers: Tuning Inherent Stability and Release Kinetics in Water. ACS Omega, 3(2), 2390-2395.
http://dx.doi.org/10.1021/acsomega.7b01961
---------- CHICAGO ----------
Sonego, J.M., Flórez-Castillo, J.M., Jobbágy, M. "Highly Structured Polyvinyl Alcohol Porous Carriers: Tuning Inherent Stability and Release Kinetics in Water" . ACS Omega 3, no. 2 (2018) : 2390-2395.
http://dx.doi.org/10.1021/acsomega.7b01961
---------- MLA ----------
Sonego, J.M., Flórez-Castillo, J.M., Jobbágy, M. "Highly Structured Polyvinyl Alcohol Porous Carriers: Tuning Inherent Stability and Release Kinetics in Water" . ACS Omega, vol. 3, no. 2, 2018, pp. 2390-2395.
http://dx.doi.org/10.1021/acsomega.7b01961
---------- VANCOUVER ----------
Sonego, J.M., Flórez-Castillo, J.M., Jobbágy, M. Highly Structured Polyvinyl Alcohol Porous Carriers: Tuning Inherent Stability and Release Kinetics in Water. ACS Omega. 2018;3(2):2390-2395.
http://dx.doi.org/10.1021/acsomega.7b01961