Demertzi, A.; Tagliazucchi, E.; Dehaene, S.; Deco, G.; Barttfeld, P.; Raimondo, F.; Martial, C.; Fernández-Espejo, D.; Rohaut, B.; Voss, H.U.; Schiff, N.D.; Owen, A.M.; Laureys, S.; Naccache, L.; Sitt, J.D. "Human consciousness is supported by dynamic complex patterns of brain signal coordination" (2019) Science Advances. 5(2)
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Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern’s implication in consciousness. Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness. Our results establish that consciousness rests on the brain’s ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious states. Copyright © 2019 The Authors.


Documento: Artículo
Título:Human consciousness is supported by dynamic complex patterns of brain signal coordination
Autor:Demertzi, A.; Tagliazucchi, E.; Dehaene, S.; Deco, G.; Barttfeld, P.; Raimondo, F.; Martial, C.; Fernández-Espejo, D.; Rohaut, B.; Voss, H.U.; Schiff, N.D.; Owen, A.M.; Laureys, S.; Naccache, L.; Sitt, J.D.
Filiación:GIGA-Consciousness, GIGA Institute B34, University of Liège, Avenue de l’Hôpital, 11, Sart Tilman, 4000, Belgium
INSERM, U 1127, Paris, F-75013, France
Institut du Cerveau et de la Moelle Epinière, Hôpital Pitié-Salpêtrière, 47 bd de l’Hôpital, Paris, 75013, France
Instituto de Física de Buenos Aires, Physics Deparment (University of Buenos Aires), Buenos Aires, Argentina
Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Sud, Université Paris-Saclay, Gif/Yvette, F-91191, France
Collège de France, 11, Place Marcelin Berthelot, Paris, 75005, France
Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Calle Ramon Trias Fargas 25-27, Barcelona, 08005, Spain
Institucio Catalana de la Recerca I Estudis Avancats (ICREA), University of Pompeu Fabra, Passeig Lluis Companys 23, Barcelona, 08010, Spain
Laboratory of Integrative Neuroscience, Physics Department, FCEyN UBA and IFIBA, CONICET, Ciudad Universitaria, Pabellón 1, Buenos Aires, 1428, Argentina
Department of Computer Science, Faculty of Exact and Natural Sciences, University of Buenos Aires, Intendente Güiraldes 2160–Ciudad UniversitariaC1428EGA, Argentina
Sorbonne Universités, UPMC Université Paris 06, Faculté de Médecine Pitié-Salpêtrière, 91-105 bd de l’Hôpital, Paris, 75013, France
CONICET, Universidad de Buenos Aires, Instituto de Investigación en Ciencias de la Computación, Godoy Cruz 2290, Ciudad Autónoma de Buenos Aires, C1425FQB, Argentina
Centre for Human Brain Health, University of Birmingham, Birmingham, B15 2TT, United Kingdom
School of Psychology, University of Birmingham, Birmingham, B15 2TT, United Kingdom
Brain and Mind Institute, Western Interdisciplinary Research Building, N6A 5B7, University of Western Ontario, London, ON, Canada
Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032-3784, United States
Radiology Department, Citigroup Biomedical Imaging Center, Weill Cornell Medical College, 516 E. 72nd Street, New York, NY 10021, United States
Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, United States
Instituto de Investigaciones Psicológicas (IIPSI) CONICET, Enfermera Gordillo s/n, Córdoba, Argentina
Palabras clave:Magnetic resonance imaging; Neuroimaging; Complex pattern; Dynamic patterns; Dynamic signals; Functional magnetic resonance imaging; Healthy individuals; Human consciousness; Phase coherence; Structural connectivity; Coordination reactions
Título revista:Science Advances
Título revista abreviado:Sci. Adv.


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---------- APA ----------
Demertzi, A., Tagliazucchi, E., Dehaene, S., Deco, G., Barttfeld, P., Raimondo, F., Martial, C.,..., Sitt, J.D. (2019) . Human consciousness is supported by dynamic complex patterns of brain signal coordination. Science Advances, 5(2).
---------- CHICAGO ----------
Demertzi, A., Tagliazucchi, E., Dehaene, S., Deco, G., Barttfeld, P., Raimondo, F., et al. "Human consciousness is supported by dynamic complex patterns of brain signal coordination" . Science Advances 5, no. 2 (2019).
---------- MLA ----------
Demertzi, A., Tagliazucchi, E., Dehaene, S., Deco, G., Barttfeld, P., Raimondo, F., et al. "Human consciousness is supported by dynamic complex patterns of brain signal coordination" . Science Advances, vol. 5, no. 2, 2019.
---------- VANCOUVER ----------
Demertzi, A., Tagliazucchi, E., Dehaene, S., Deco, G., Barttfeld, P., Raimondo, F., et al. Human consciousness is supported by dynamic complex patterns of brain signal coordination. Sci. Adv. 2019;5(2).