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Abstract:

Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of external ligands such as hormones or neurotransmitters. The analysis of intracellular Ca2+ pulses that involve Ca2+ release through inositol 1,4,5-trisphosphate (IP3) receptors led to a model with stochastic pulse firing at rate, λ and deterministic inhibition with recovery at rate, ρ. Here we combine this model with recent observations that established an exponential relationship between λ and the external ligand concentration, C. We compute analytically the mutual information between C and the interpulse time, t, or the number of pulses, N, in the λ/ρ ≪ 1 and λ/ρ ≫ 1 limits. We obtain that both I(C, t) and I(C, N) are largest in the second limit with a difference of at most ~1bit. Thus, the resolution with which the values of C can be discriminated at most doubles in one limit with respect to the other. The components of the model and the exponential dependence of the firing rate with C are features common to noise-driven excitable systems. Our results thus hold in this more general setting that applies widely in biology. © 2018 Givré and Ponce Dawson.

Registro:

Documento: Artículo
Título:Information content in stochastic pulse sequences of intracellular messengers
Autor:Givré, A.; Dawson, S.P.
Filiación:Departamento de Física, FCEN-UBA, Buenos Aires, Argentina
IFIBA, Consejo Nacional de Investigaciones Científicas y Técnicas, UBA, Buenos Aires, Argentina
Palabras clave:Ca2+ pulses; Cell signaling; Information; Inhibition; Poisson processes
Año:2018
Volumen:6
Número:JUL
DOI: http://dx.doi.org/10.3389/fphy.2018.00074
Título revista:Frontiers in Physics
Título revista abreviado:Front. Phys.
ISSN:2296424X
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_2296424X_v6_nJUL_p_Givre

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Citas:

---------- APA ----------
Givré, A. & Dawson, S.P. (2018) . Information content in stochastic pulse sequences of intracellular messengers. Frontiers in Physics, 6(JUL).
http://dx.doi.org/10.3389/fphy.2018.00074
---------- CHICAGO ----------
Givré, A., Dawson, S.P. "Information content in stochastic pulse sequences of intracellular messengers" . Frontiers in Physics 6, no. JUL (2018).
http://dx.doi.org/10.3389/fphy.2018.00074
---------- MLA ----------
Givré, A., Dawson, S.P. "Information content in stochastic pulse sequences of intracellular messengers" . Frontiers in Physics, vol. 6, no. JUL, 2018.
http://dx.doi.org/10.3389/fphy.2018.00074
---------- VANCOUVER ----------
Givré, A., Dawson, S.P. Information content in stochastic pulse sequences of intracellular messengers. Front. Phys. 2018;6(JUL).
http://dx.doi.org/10.3389/fphy.2018.00074