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Barttfeld, P.; Bekinschtein, T.A.; Salles, A.; Stamatakis, E.A.; Adapa, R.; Menon, D.K.; Sigman, M. "Factoring the brain signatures of anesthesia concentration and level of arousal across individuals" (2015) NeuroImage: Clinical. 9:385-391
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Abstract:

Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex. © 2015 The Authors.

Registro:

Documento: Artículo
Título:Factoring the brain signatures of anesthesia concentration and level of arousal across individuals
Autor:Barttfeld, P.; Bekinschtein, T.A.; Salles, A.; Stamatakis, E.A.; Adapa, R.; Menon, D.K.; Sigman, M.
Filiación:Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010Buenos Aires C1428BIJ, Argentina
Cognitive Neuroimaging Unit, CEA DSV, I2BM, INSERM, Université Paris-Sud, Université Paris-Saclay, NeuroSpin center, Gif/Yvette, 91191, France
Cognition and Brain Sciences Unit, Medical Research Council, Cambridge, CB2 7EF, United Kingdom
Department of Psychology, University of Cambridge, Cambridge, United Kingdom
Instituto de Cálculo, FCEN, Universidad de Buenos Aires, CONICET, Argentina
Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Palabras clave:propofol; hypnotic sedative agent; oxygen; propofol; adult; anesthesia; arousal; Article; brain; drug blood level; factorial analysis; female; frontal cortex; frontoparietal cortex; functional magnetic resonance imaging; human; human experiment; male; normal human; nuclear magnetic resonance scanner; priority journal; response time; sedation; thalamus; arousal; blood; brain; brain mapping; drug effects; factor analysis; image processing; middle aged; nuclear magnetic resonance imaging; regression analysis; vascularization; young adult; Adult; Arousal; Brain; Brain Mapping; Factor Analysis, Statistical; Female; Humans; Hypnotics and Sedatives; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Propofol; Regression Analysis; Young Adult
Año:2015
Volumen:9
Página de inicio:385
Página de fin:391
DOI: http://dx.doi.org/10.1016/j.nicl.2015.08.013
Título revista:NeuroImage: Clinical
Título revista abreviado:NeuroImage Clin.
ISSN:22131582
CAS:propofol, 2078-54-8; oxygen, 7782-44-7; Hypnotics and Sedatives; Oxygen; Propofol
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_22131582_v9_n_p385_Barttfeld

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Citas:

---------- APA ----------
Barttfeld, P., Bekinschtein, T.A., Salles, A., Stamatakis, E.A., Adapa, R., Menon, D.K. & Sigman, M. (2015) . Factoring the brain signatures of anesthesia concentration and level of arousal across individuals. NeuroImage: Clinical, 9, 385-391.
http://dx.doi.org/10.1016/j.nicl.2015.08.013
---------- CHICAGO ----------
Barttfeld, P., Bekinschtein, T.A., Salles, A., Stamatakis, E.A., Adapa, R., Menon, D.K., et al. "Factoring the brain signatures of anesthesia concentration and level of arousal across individuals" . NeuroImage: Clinical 9 (2015) : 385-391.
http://dx.doi.org/10.1016/j.nicl.2015.08.013
---------- MLA ----------
Barttfeld, P., Bekinschtein, T.A., Salles, A., Stamatakis, E.A., Adapa, R., Menon, D.K., et al. "Factoring the brain signatures of anesthesia concentration and level of arousal across individuals" . NeuroImage: Clinical, vol. 9, 2015, pp. 385-391.
http://dx.doi.org/10.1016/j.nicl.2015.08.013
---------- VANCOUVER ----------
Barttfeld, P., Bekinschtein, T.A., Salles, A., Stamatakis, E.A., Adapa, R., Menon, D.K., et al. Factoring the brain signatures of anesthesia concentration and level of arousal across individuals. NeuroImage Clin. 2015;9:385-391.
http://dx.doi.org/10.1016/j.nicl.2015.08.013