Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

IMPORTANCE Prevention is more effective than treatment to decrease the burden of significant medical conditions such as depressive disorders, a major cause of disability worldwide. Traumatic brain injury (TBI) is a candidate for selective strategies to prevent depression given the incidence, prevalence, and functional effect of depression that occurs after TBI. OBJECTIVE To assess the efficacy of sertraline treatment in preventing depressive disorders following TBI. DESIGN, SETTING, AND PARTICIPANTS A double-blind, placebo-controlled, parallel-group randomized clinical trial was conducted at a university hospital from July 3, 2008, to September 17, 2012, with 24 weeks of follow-up. A consecutive sample of 534 patients aged 18 to 85 years, hospitalized for mild, moderate, or severe TBI, was eligible for the study. Ninety-four patients consented to participate and were randomized (46 to placebo and 48 to sertraline), of whom 79 (84%) completed the study. Intention-To-Treat data analysis was conducted from July 1, 2014, to December 31, 2015. INTERVENTIONS Placebo or sertraline, 100mg/d, for 24 weeks or until development of a mood disorder. MAIN OUTCOMES AND MEASURES Time to onset of depressive disorders, as defined by the DSM-IV, associated with TBI. RESULTS Of the 94 patients in the study (38 female and 56 male; 92 white), the number needed to treat to prevent depression after TBI at 24 weeks was 5.9 (95%CI, 3.1-71.1; x2 = 4.6; P = .03) for sertraline treatment vs placebo. The influence of sertraline in the course of neuropsychological variables was not detected. The intervention was well tolerated, and adverse effects were mild in both the sertraline and placebo groups. CONCLUSIONS AND RELEVANCE Sertraline appears to be efficacious to prevent the onset of depressive disorders following TBI. Future studies should replicate these findings in a large sample of patients with TBI and depict their long-Term physical, cognitive, behavioral, and functional outcomes. Copyright 2016 American Medical Association. All rights reserved.

Registro:

Documento: Artículo
Título:Sertraline for preventing mood disorders following traumatic brain injury a randomized clinical trial
Autor:Jorge, R.E.; Acion, L.; Burin, D.I.; Robinson, R.G.
Filiación:Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
Iowa Consortium for Substance Abuse Research and Evaluation, University of Iowa, Iowa City, United States
Instituto de Cálculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Facultad de Psicología, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Department of Psychiatry, University of Iowa, Iowa City, United States
Palabras clave:placebo; sertraline; sertraline; adult; aged; Article; controlled study; depression; diarrhea; dizziness; double blind procedure; fatigue; female; follow up; human; injury severity; insomnia; major clinical study; male; mood disorder; nausea; neuropsychological test; physiotherapy; randomized controlled trial; side effect; sweating; traumatic brain injury; xerostomia; complication; cross-sectional study; Denmark; Depressive Disorder; intention to treat analysis; middle aged; mortality; psychology; register; traumatic brain injury; treatment outcome; university hospital; young adult; Adult; Aged; Brain Injuries, Traumatic; Cross-Sectional Studies; Denmark; Depressive Disorder; Double-Blind Method; Female; Follow-Up Studies; Hospitals, University; Humans; Intention to Treat Analysis; Male; Middle Aged; Registries; Sertraline; Treatment Outcome; Young Adult
Año:2016
Volumen:73
Número:10
Página de inicio:1041
Página de fin:1047
DOI: http://dx.doi.org/10.1001/jamapsychiatry.2016.2189
Título revista:JAMA Psychiatry
Título revista abreviado:JAMA Psychiatry
ISSN:2168622X
CAS:sertraline, 79617-96-2; Sertraline
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_2168622X_v73_n10_p1041_Jorge

Referencias:

  • Faul, M., Coronado, V., Epidemiology of traumatic brain injury (2015) Handb Clin Neurol, 127, pp. 3-13
  • Finkelstein, E., Corso, P.S., Miller, T.R., (2006) The Incidence and Economic Burden of Injuries in the United States, , New York, NY: Oxford University Press
  • Seel, R.T., Macciocchi, S., Kreutzer, J.S., Clinical considerations for the diagnosis of major depression after moderate to severe TBI (2010) J Head Trauma Rehabil, 25 (2), pp. 99-112
  • Brooks, N., Campsie, L., Symington, C., Beattie, A., McKinlay, W., The five year outcome of severe blunt head injury: A relatives view (1986) J Neurol Neurosurg Psychiatry, 49 (7), pp. 764-770
  • Gualtieri, T., Cox, D.R., The delayed neurobehavioural sequelae of traumatic brain injury (1991) Brain Inj, 5 (3), pp. 219-232
  • Jorge, R., Robinson, R.G., Mood disorders following traumatic brain injury (2002) NeuroRehabilitation, 17 (4), pp. 311-324
  • McKinlay, W.W., Brooks, D.N., Bond, M.R., Martinage, D.P., Marshall, M.M., The short-Term outcome of severe blunt head injury as reported by relatives of the injured persons (1981) J Neurol Neurosurg Psychiatry, 44 (6), pp. 527-533
  • Schoenhuber, R., Gentilini, M., Anxiety and depression after mild head injury: A case control study (1988) J Neurol Neurosurg Psychiatry, 51 (5), pp. 722-724
  • Van Reekum, R., Bolago, I., Finlayson, M.A., Garner, S., Links, P.S., Psychiatric disorders after traumatic brain injury (1996) Brain Inj, 10 (5), pp. 319-327
  • Deb, S., Lyons, I., Koutzoukis, C., Ali, I., McCarthy, G., Rate of psychiatric illness 1 year after traumatic brain injury (1999) Am J Psychiatry, 156 (3), pp. 374-378
  • Fann, J.R., Katonwj Uomoto, J.M., Esselman, P.C., Psychiatric disorders and functional disability in outpatients with traumatic brain injuries (1995) Am J Psychiatry, 152 (10), pp. 1493-1499
  • Hibbard, M.R., Uysal, S., Kepler, K., Bogdany, J., Silver, J., Axis i psychopathology in individuals with traumatic brain injury (1998) J Head Trauma Rehabil, 13 (4), pp. 24-39
  • Holsinger, T., Steffens, D.C., Phillips, C., Head injury in early adulthood and the lifetime risk of depression (2002) Arch Gen Psychiatry, 59 (1), pp. 17-22
  • Jorge, R.E., Robinson, R.G., Moser, D., Tateno, A., Crespo-Facorro, B., Arndt, S., Major depression following traumatic brain injury (2004) Arch Gen Psychiatry, 61 (1), pp. 42-50
  • Kreutzer, J.S., Seel, R.T., Gourley, E., The prevalence and symptom rates of depression after traumatic brain injury: A comprehensive examination (2001) Brain Inj, 15 (7), pp. 563-576
  • Silver, J.M., Kramer, R., Greenwald, S., Weissman, M., The association between head injuries and psychiatric disorders: Findings from the New Haven NIMH Epidemiologic Catchment Area Study (2001) Brain Inj, 15 (11), pp. 935-945
  • Jorge, R.E., Robinson, R.G., Arndt, S.V., Forrester, A.W., Geisler, F., Starkstein, S.E., Comparison between acute-And delayed-onset depression following traumatic brain injury (1993) J Neuropsychiatry Clin Neurosci, 5 (1), pp. 43-49
  • Bombardier, C.H., Fann, J.R., Temkin, N.R., Esselman, P.C., Barber, J., Dikmen, S.S., Rates of major depressive disorder and clinical outcomes following traumatic brain injury (2010) JAMA, 303 (19), pp. 1938-1945
  • Gould, K.R., Ponsford, J.L., Johnston, L., Schberger, M., The nature, frequency and course of psychiatric disorders in the first year after traumatic brain injury: A prospective study (2011) Psychol Med, 41 (10), pp. 2099-2109
  • Hart, T., Hoffman, J.M., Pretz, C., Kennedy, R., Clark, A.N., Brenner, L.A., A longitudinal study of major and minor depression following traumatic brain injury (2012) Arch Phys Med Rehabil, 93 (8), pp. 1343-1349
  • Koponen, S., Taiminen, T., Portin, R., Axis i and II psychiatric disorders after traumatic brain injury: A 30-year follow-up study (2002) Am J Psychiatry, 159 (8), pp. 1315-1321
  • Jorge, R.E., Robinson, R.G., Starkstein, S.E., Arndt, S.V., Influence of major depression on 1-year outcome in patients with traumatic brain injury (1994) J Neurosurg, 81 (5), pp. 726-733
  • Bowen, A., Neumann, V., Conner, M., Tennant, A., Chamberlain, M.A., Mood disorders following traumatic brain injury: Identifying the extent of the problem and the people at risk (1998) Brain Inj, 12 (3), pp. 177-190
  • Fann, J.R., Burington, B., Leonetti, A., Jaffe, K., Katon, W.J., Thompson, R.S., Psychiatric illness following traumatic brain injury in an adult health maintenance organization population (2004) Arch Gen Psychiatry, 61 (1), pp. 53-61
  • Satz, P., Forney, D.L., Zaucha, K., Depression, cognition, and functional correlates of recovery outcome after traumatic brain injury (1998) Brain Inj, 12 (7), pp. 537-553
  • Rapoport, M.J., McCullagh, S., Streiner, D., Feinstein, A., The clinical significance of major depression following mild traumatic brain injury (2003) Psychosomatics, 44 (1), pp. 31-37
  • Hudak, A.M., Hynan, L.S., Harper, C.R., Diaz-Arrastia, R., Association of depressive symptoms with functional outcome after traumatic brain injury (2012) J Head Trauma Rehabil, 27 (2), pp. 87-98
  • Reynolds, C.F., III, Dew, M.A., Lenze, E.J., Whyte, E.M., Preventing depression in medical illness: A new lead? (2007) Arch Gen Psychiatry, 64 (8), pp. 884-885
  • Beekman, A.T., Smit, F., Stek, M.L., Reynolds, C.F., III, Cuijpers, P.C., Preventing depression in high-risk groups (2010) Curr Opin Psychiatry, 23 (1), pp. 8-11
  • Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., The mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 (1998) J Clin Psychiatry, 59, pp. 22-33
  • McGahuey, C.A., Gelenberg, A.J., Laukes, C.A., The arizona sexual experience scale (ASEX): Reliability and validity (2000) J Sex Marital Ther, 26 (1), pp. 25-40
  • Lydersen, S., Fagerland, M.W., Laake, P., Recommended tests for association in 2 x 2 tables (2009) Stat Med, 28 (7), pp. 1159-1175
  • Folstein, M.F., Folstein, S.E., McHugh, P.R., Mini-mental state": A practical method for grading the cognitive state of patients for the clinician (1975) J Psychiatr Res, 12 (3), pp. 189-198
  • Van Zoonen, K., Buntrock, C., Ebert, D.D., Preventing the onset of major depressive disorder: Ameta-Analytic review of psychological interventions (2014) Int J Epidemiol, 43 (2), pp. 318-329
  • Robinson, R.G., Jorge, R.E., Moser, D.J., Escitalopram and problem-solving therapy for prevention of poststroke depression: A randomized controlled trial (2008) JAMA, 299 (20), pp. 2391-2400
  • Ashman, T.A., Cantor, J.B., Gordon, W.A., A randomized controlled trial of sertraline for the treatment of depression in persons with traumatic brain injury (2009) Arch Phys Med Rehabil, 90 (5), pp. 733-740
  • Barker-Collo, S., Starkey, N., Theadom, A., Treatment for depression following mild traumatic brain injury in adults: Ameta-Analysis (2013) Brain Inj, 27 (10), pp. 1124-1133
  • Hertz, L., Rothman, D.L., Li, B., Peng, L., Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: A potential paradigm shift (2015) Front Behav Neurosci, 9, p. 25
  • Karpova, N.N., Pickenhagen, A., Lindholm, J., Fear erasure in mice requires synergy between antidepressant drugs and extinction training [published correction appears in (2012) Science, 335 (6069), p. 657
  • (2011) Science, 334 (6063), pp. 1731-1734
  • Brody, D.L., Benetatos, J., Bennett, R.E., Klemenhagen, K.C., Mac Donald, C.L., The pathophysiology of repetitive concussive traumatic brain injury in experimental models; New developments and open questions (2015) Mol Cell Neurosci, 66, pp. 91-98
  • Jorge, R.E., Acion, L., Moser, D., Adams, H.P., Jr., Robinson, R.G., Escitalopram and enhancement of cognitive recovery following stroke (2010) Arch Gen Psychiatry, 67 (2), pp. 187-196

Citas:

---------- APA ----------
Jorge, R.E., Acion, L., Burin, D.I. & Robinson, R.G. (2016) . Sertraline for preventing mood disorders following traumatic brain injury a randomized clinical trial. JAMA Psychiatry, 73(10), 1041-1047.
http://dx.doi.org/10.1001/jamapsychiatry.2016.2189
---------- CHICAGO ----------
Jorge, R.E., Acion, L., Burin, D.I., Robinson, R.G. "Sertraline for preventing mood disorders following traumatic brain injury a randomized clinical trial" . JAMA Psychiatry 73, no. 10 (2016) : 1041-1047.
http://dx.doi.org/10.1001/jamapsychiatry.2016.2189
---------- MLA ----------
Jorge, R.E., Acion, L., Burin, D.I., Robinson, R.G. "Sertraline for preventing mood disorders following traumatic brain injury a randomized clinical trial" . JAMA Psychiatry, vol. 73, no. 10, 2016, pp. 1041-1047.
http://dx.doi.org/10.1001/jamapsychiatry.2016.2189
---------- VANCOUVER ----------
Jorge, R.E., Acion, L., Burin, D.I., Robinson, R.G. Sertraline for preventing mood disorders following traumatic brain injury a randomized clinical trial. JAMA Psychiatry. 2016;73(10):1041-1047.
http://dx.doi.org/10.1001/jamapsychiatry.2016.2189