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Abstract:

Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy. © 2016 Taylor & Francis Group, LLC.

Registro:

Documento: Artículo
Título:The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity
Autor:Alamino, V.A.; Montesinos, M.M.; Rabinovich, G.A.; Pellizas, C.G.
Filiación:Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Universidad Nacional de Córdoba, Córdoba, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Departamento de Química Biológica, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Cancer vaccination; Dendritic cell; Immunotherapy; Thyroid hormone; Triiodothyronine; cancer vaccine; gamma interferon; liothyronine; Article; cell differentiation; cross presentation; dendritic cell; immune response; immunogenicity; nonhuman; protein expression; signal transduction; tumor growth; tumor immunity
Año:2016
Volumen:5
Número:1
DOI: http://dx.doi.org/10.1080/2162402X.2015.1064579
Título revista:OncoImmunology
Título revista abreviado:OncoImmunology
ISSN:21624011
CAS:gamma interferon, 82115-62-6; liothyronine, 6138-47-2, 6893-02-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_21624011_v5_n1_p_Alamino

Referencias:

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Citas:

---------- APA ----------
Alamino, V.A., Montesinos, M.M., Rabinovich, G.A. & Pellizas, C.G. (2016) . The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity. OncoImmunology, 5(1).
http://dx.doi.org/10.1080/2162402X.2015.1064579
---------- CHICAGO ----------
Alamino, V.A., Montesinos, M.M., Rabinovich, G.A., Pellizas, C.G. "The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity" . OncoImmunology 5, no. 1 (2016).
http://dx.doi.org/10.1080/2162402X.2015.1064579
---------- MLA ----------
Alamino, V.A., Montesinos, M.M., Rabinovich, G.A., Pellizas, C.G. "The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity" . OncoImmunology, vol. 5, no. 1, 2016.
http://dx.doi.org/10.1080/2162402X.2015.1064579
---------- VANCOUVER ----------
Alamino, V.A., Montesinos, M.M., Rabinovich, G.A., Pellizas, C.G. The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity. OncoImmunology. 2016;5(1).
http://dx.doi.org/10.1080/2162402X.2015.1064579