Artículo
Croci, D.O.; Rabinovich, G.A. "Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference" (2014) OncoImmunology. 3(6)
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Abstract:
Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complex N-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.
Registro:
| Documento: | Artículo |
| Título: | Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference |
| Autor: | Croci, D.O.; Rabinovich, G.A. |
| Filiación: | Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina Laboratorio de Glicómica, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
| Palabras clave: | Angiogenesis; anti-VEGF; Cancer immunotherapy; Galectin; Glycans; Glycosylation; Inflammation; glycan; glycosyltransferase; immunoglobulin G3; immunoglobulin G4; vasculotropin receptor 2; article; carcinogenesis; catalysis; cell adhesion; glycosylation; human; hypoxia; lymphocyte proliferation; melanoma; nonhuman; protein binding; protein domain; protein processing; protein protein interaction; protein structure; sialylation; signal transduction; tumor microenvironment; tumor vascularization; upregulation |
| Año: | 2014 |
| Volumen: | 3 |
| Número: | 6 |
| DOI: | http://dx.doi.org/10.4161/onci.29380 |
| Título revista: | OncoImmunology |
| Título revista abreviado: | OncoImmunology |
| ISSN: | 21624011 |
| CAS: | glycosyltransferase, 9033-07-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_21624011_v3_n6_p_Croci |
Referencias:
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Citas:
---------- APA ----------
Croci, D.O. & Rabinovich, G.A. (2014) . Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference. OncoImmunology, 3(6).http://dx.doi.org/10.4161/onci.29380
---------- CHICAGO ----------
Croci, D.O., Rabinovich, G.A. "Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference" . OncoImmunology 3, no. 6 (2014).http://dx.doi.org/10.4161/onci.29380
---------- MLA ----------
Croci, D.O., Rabinovich, G.A. "Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference" . OncoImmunology, vol. 3, no. 6, 2014.http://dx.doi.org/10.4161/onci.29380
---------- VANCOUVER ----------
Croci, D.O., Rabinovich, G.A. Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference. OncoImmunology. 2014;3(6).http://dx.doi.org/10.4161/onci.29380
