Artículo
Compagno, D.; Laderach, J.D.; Gentilini, L.; Jaworski, M.F.; Rabinovich, A.G. "Delineating the "galectin signature" of the tumor microenvironment" (2013) OncoImmunology. 2(4)
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Abstract:
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease. © 2013 Landes Bioscience.
Registro:
| Documento: | Artículo |
| Título: | Delineating the "galectin signature" of the tumor microenvironment |
| Autor: | Compagno, D.; Laderach, J.D.; Gentilini, L.; Jaworski, M.F.; Rabinovich, A.G. |
| Filiación: | Laboratorio de Glicómica Estructural y Funcional, IQUIBICEN-CONICET, Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina |
| Palabras clave: | Angiogenesis; Galectins; Gene signature; Metastasis; Prostate cancer; angiogenesis inhibitor; ecalectin; galectin; galectin 1; galectin 12; galectin 3; galectin 4; galectin 8; messenger RNA; short hairpin RNA; unclassified drug; advanced cancer; antiangiogenic therapy; article; cancer cell culture; cancer growth; cancer prognosis; cancer staging; cancer therapy; castration resistant prostate cancer; cell invasion; cell migration; cellular immunity; down regulation; human; hypoxia; Kaposi sarcoma; molecular mechanics; prostate cancer; prostatectomy; protein carbohydrate interaction; protein expression; protein function; protein structure; protein synthesis inhibition; protein targeting; structure analysis; tumor microenvironment; tumor vascularization; upregulation |
| Año: | 2013 |
| Volumen: | 2 |
| Número: | 4 |
| DOI: | http://dx.doi.org/10.4161/onci.23565 |
| Título revista: | OncoImmunology |
| Título revista abreviado: | OncoImmunology |
| ISSN: | 21624011 |
| CAS: | galectin 1, 258495-34-0; galectin 3, 208128-56-7; galectin 8, 220452-97-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_21624011_v2_n4_p_Compagno |
Referencias:
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- Laderach, D.J., Gentilini, L.D., Giribaldi, L., Delgado, V.C., Nugnes, L., Croci, D.O., A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease (2013) Cancer Res, 73, pp. 86-96. , http://dx.doi.org/10.1158/0008-5472.CAN-12-1260
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Citas:
---------- APA ----------
Compagno, D., Laderach, J.D., Gentilini, L., Jaworski, M.F. & Rabinovich, A.G. (2013) . Delineating the "galectin signature" of the tumor microenvironment. OncoImmunology, 2(4).http://dx.doi.org/10.4161/onci.23565
---------- CHICAGO ----------
Compagno, D., Laderach, J.D., Gentilini, L., Jaworski, M.F., Rabinovich, A.G. "Delineating the "galectin signature" of the tumor microenvironment" . OncoImmunology 2, no. 4 (2013).http://dx.doi.org/10.4161/onci.23565
---------- MLA ----------
Compagno, D., Laderach, J.D., Gentilini, L., Jaworski, M.F., Rabinovich, A.G. "Delineating the "galectin signature" of the tumor microenvironment" . OncoImmunology, vol. 2, no. 4, 2013.http://dx.doi.org/10.4161/onci.23565
---------- VANCOUVER ----------
Compagno, D., Laderach, J.D., Gentilini, L., Jaworski, M.F., Rabinovich, A.G. Delineating the "galectin signature" of the tumor microenvironment. OncoImmunology. 2013;2(4).http://dx.doi.org/10.4161/onci.23565
